143207

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) chpSB/PRK09812-ChpS
Location 4946479..4947074 Replicon chromosome
Accession NZ_CP045975
Organism Escherichia coli strain AUSMDU00002545

Toxin (Protein)


Gene name chpB Uniprot ID U9Y4M4
Locus tag GJD97_RS24635 Protein ID WP_000239579.1
Coordinates 4946479..4946829 (-) Length 117 a.a.

Antitoxin (Protein)


Gene name chpS Uniprot ID Q8XCF3
Locus tag GJD97_RS24640 Protein ID WP_001223210.1
Coordinates 4946823..4947074 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GJD97_RS24615 4941925..4942947 - 1023 WP_001301928.1 ABC transporter permease -
GJD97_RS24620 4942961..4944463 - 1503 WP_000205805.1 sugar ABC transporter ATP-binding protein -
GJD97_RS24625 4944603..4945559 - 957 WP_000265942.1 galactofuranose ABC transporter substrate-binding protein YtfQ -
GJD97_RS24630 4945869..4946399 + 531 WP_000055075.1 inorganic diphosphatase -
GJD97_RS24635 4946479..4946829 - 351 WP_000239579.1 endoribonuclease toxin ChpB Toxin
GJD97_RS24640 4946823..4947074 - 252 WP_001223210.1 type II toxin-antitoxin system antitoxin ChpS Antitoxin
GJD97_RS24645 4947286..4947627 - 342 WP_001219160.1 gamma-glutamylcyclotransferase -
GJD97_RS24650 4947630..4951409 - 3780 WP_000060930.1 autotransporter assembly complex protein TamB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(8-114)

Antitoxin

SpoVT-AbrB domain

(6-49)


Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12511.45 Da        Isoelectric Point: 5.6219

>T143207 WP_000239579.1 NZ_CP045975:c4946829-4946479 [Escherichia coli]
MVKKSEFERGDIVLVGFDPASGHEQQGAGRPALVLSVQAFNQLGMTLVAPITQGGNFARYAGFSVPLHCEEGDVHGVVLV
NQVRMMDLRARLAKRIGLAADEVVEEALLRLQAVVE

Download         Length: 351 bp

>T143207 NZ_CP060969:2725590-2725697 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCATGATTTTCTGGCACGACCTGGCAGCACCGATCCTGGCGGGAATTATTACCGCAGCGAT
TGTCAGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9299.64 Da        Isoelectric Point: 4.4201

>AT143207 WP_001223210.1 NZ_CP045975:c4947074-4946823 [Escherichia coli]
MRITIKRWGNSAGMVIPNIVMKELNLQPGQSVEVQVSNNQLILTPISRRYSLDELLAQCDMNAAELSEQDVWGKSTPAGD
EIW

Download         Length: 252 bp

>AT143207 NZ_CP060969:c2725543-2725477 [Escherichia coli]
TGTCTGGTTTCAAGATTAGCCCCCGTTTTGTTGTCAGGTTTTACCTCTCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0Y8A8

Antitoxin

Source ID Structure

References