Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 4200390..4201008 Replicon chromosome
Accession NZ_CP045975
Organism Escherichia coli strain AUSMDU00002545

Toxin (Protein)


Gene name Hha Uniprot ID H5UYE2
Locus tag GJD97_RS21280 Protein ID WP_001291435.1
Coordinates 4200790..4201008 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID -
Locus tag GJD97_RS21275 Protein ID WP_154074646.1
Coordinates 4200390..4200764 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GJD97_RS21265 4195479..4196672 + 1194 WP_001295324.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
GJD97_RS21270 4196695..4199844 + 3150 WP_001132452.1 multidrug efflux RND transporter permease subunit -
GJD97_RS21275 4200390..4200764 + 375 WP_154074646.1 Hha toxicity modulator TomB Antitoxin
GJD97_RS21280 4200790..4201008 + 219 WP_001291435.1 hemolysin expression modulator Hha Toxin
GJD97_RS21285 4201180..4201731 + 552 WP_000102553.1 maltose O-acetyltransferase -
GJD97_RS21290 4201847..4202317 + 471 WP_000136192.1 YlaC family protein -
GJD97_RS21295 4202481..4204031 + 1551 WP_001301851.1 cyclic-guanylate-specific phosphodiesterase PdeB -
GJD97_RS21300 4204073..4204426 - 354 WP_000878140.1 DUF1428 domain-containing protein -
GJD97_RS21310 4204805..4205116 + 312 WP_000409911.1 MGMT family protein -
GJD97_RS21315 4205149..4205721 - 573 WP_000779831.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T143201 WP_001291435.1 NZ_CP045975:4200790-4201008 [Escherichia coli]
MSEKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

>T143201 NZ_CP060969:1854650-1854901 [Escherichia coli]
ATGCGTACAATTAGTTACAGCGAAGCGCGTCAGAATTTGTCGGCAACAATGATGAAAGCCGTTGAAGATCATGCCCCGAT
CCTCATTACTCGTCAGAATGGAGAGGCTTGTGTTCTGATGTCACTCGAAGAATACAACTCGCTGGAAGAGACGGCTTATC
TACTGCGTTCCCCCGCTAACGCCCGGAGATTGATGGACTCAATCGATAGCCTGAAATCAGGCAAAGGAACGGAAAAGGAC
ATTATTGAGTGA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14571.42 Da        Isoelectric Point: 4.7493

>AT143201 WP_154074646.1 NZ_CP045975:4200390-4200764 [Escherichia coli]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNEPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQDLQKWRKSGNRLFRCFVNATKENPASLSC

Download         Length: 375 bp

>AT143201 NZ_CP060969:1854898-1855152 [Escherichia coli]
GTGAAACTAATCTGGTCTGAGGAATCATGGGATGATTATCTGTACTGGCAGGAAACAGATAAGCGAATTGTTAAAAAGAT
CAATGAACTTATCAAAGATACCCGCAGAACGCCATTTGAAGGTAAGGGGAAGCCAGAACCCCTGAAACATAATTTGTCAG
GTTTCTGGTCCCGACGCATTACAGAGGAGCACCGTCTGGTATACGCGGTTACCGACGATTCACTGCTCATTGCAGCATGT
CGTTATCATTATTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2MW2
PDB 1JW2

Antitoxin

Source ID Structure

References