Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) paaR-paaA-parE/-
Location 3579388..3579866 Replicon chromosome
Accession NZ_CP045975
Organism Escherichia coli strain AUSMDU00002545

Toxin (Protein)


Gene name parE_1 Uniprot ID A0A891SFN9
Locus tag GJD97_RS18485 Protein ID WP_001303876.1
Coordinates 3579579..3579866 (+) Length 96 a.a.

Antitoxin (Protein)


Gene name paaA Uniprot ID Q8XD67
Locus tag GJD97_RS18480 Protein ID WP_000536233.1
Coordinates 3579388..3579579 (+) Length 64 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GJD97_RS18445 3574792..3575562 - 771 WP_000450992.1 DUF1627 domain-containing protein -
GJD97_RS18450 3575584..3576330 - 747 WP_000788751.1 ATP-binding protein -
GJD97_RS18455 3576337..3577428 - 1092 WP_001205823.1 hypothetical protein -
GJD97_RS18460 3577507..3577962 + 456 WP_000273724.1 hypothetical protein -
GJD97_RS18465 3578169..3578594 - 426 WP_000693855.1 Rha family transcriptional regulator -
GJD97_RS18470 3578578..3578850 - 273 WP_000887453.1 helix-turn-helix domain-containing protein -
GJD97_RS18475 3578959..3579360 + 402 WP_000986592.1 helix-turn-helix domain-containing protein -
GJD97_RS18480 3579388..3579579 + 192 WP_000536233.1 hypothetical protein Antitoxin
GJD97_RS18485 3579579..3579866 + 288 WP_001303876.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
GJD97_RS18490 3580144..3580299 + 156 WP_000379575.1 DUF1391 family protein -
GJD97_RS18495 3580441..3580830 + 390 WP_000394511.1 hypothetical protein -
GJD97_RS18500 3581017..3581202 - 186 WP_001133046.1 hypothetical protein -
GJD97_RS18505 3581776..3581964 + 189 WP_000413705.1 cell division inhibition protein DicB -
GJD97_RS18510 3581961..3582152 + 192 WP_001098307.1 DUF1482 family protein -
GJD97_RS18515 3582246..3584717 + 2472 WP_000034474.1 exonuclease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-91)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 10978.84 Da        Isoelectric Point: 10.1360

>T143199 WP_001303876.1 NZ_CP045975:3579579-3579866 [Escherichia coli]
MLPILWLPSARDDLRQIITYIAKENPPAARRLKIRIETSVLPLSEHPYLYPPSERVSGLREIVTHPNYIILYRVAASSIE
IVSVTHSRRQFPFSI

Download         Length: 288 bp

>T143199 NZ_CP060969:943325-943732 [Escherichia coli]
GTGGTCCTGTGGCAATCTGATTTGCGCGTCTCCTGGCGCGCACAGTGGCTTTCCTTGCTGATTCATGGGCTGGTTGCCGC
TGTTATTTTACTCATGCCCTGGCCACTCAGTTACACCCCGTTATGGATGGTGTTACTTTCGCTGGTGGTGTTTGATTGCG
TTCGCAGCCAGCGGCGTATTAATGCTCGCCAGGGGGAAATTCGCTTGTTGATGGACGGGCGTTTGCGTTGGCAAGGGCAG
GAGTGGAGCATCGTCAAAGCACCGTGGATGATTAAGAGCGGCATGATGCTGCGTTTACGTTCTGATGGCGGTAAACGGCA
ACATTTATGGCTGGCAGCCGACAGCATGGACGAAGCTGAATGGCGGGATTTACGGCGGATTTTGTTGCAACAAGAGACGC
AAAGATAA

Antitoxin


Download         Length: 64 a.a.        Molecular weight: 7025.80 Da        Isoelectric Point: 4.0270

>AT143199 WP_000536233.1 NZ_CP045975:3579388-3579579 [Escherichia coli]
MGTALSPIVSEFETTEQENSYNEWLRTKVTSSLADTRPAIPHDEVMAEMENLIAQIAVTNKSE

Download         Length: 192 bp

>AT143199 NZ_CP060969:943078-943344 [Escherichia coli]
ATGGACATTAACAACAAAGCCCGCATTCATTGGGCATGCCGCCGTGGTATGCGCGAACTCGATATTTCAATCATGCCGTT
TTTCGAACATGAGTACGACAGCTTAAGCGATGACGAAAAACGCATCTTTATTCGTCTGCTGGAATGTGACGATCCGGACC
TGTTTAACTGGCTGATGAATCACGGTAAACCGGCCGATGCAGAACTGGAAATGATGGTCCGACTCATCCAGACACGGAAC
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References