Detailed information of TA system TA143176

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/RelE-Phd
• Location: 6269..6825
• Replicon: plasmid pAUSMDU00007395_02
• Accession: NZ_CP045965
• Organism: Mycobacterium intracellulare subsp. chimaera strain AUSMDU00007395

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: GJE02_RS29385
• Protein ID: WP_046182242.1
• Coordinates: 6550..6825 (+)
• Length: 92 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: GJE02_RS29380
• Protein ID: WP_082122855.1
• Coordinates: 6269..6553 (+)
• Length: 95 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
GJE02_RS29360	1316..1570	-	255	WP_142383129.1	antitoxin VbhA family protein	-
GJE02_RS29365	1806..4640	+	2835	WP_054585406.1	relaxase domain-containing protein	-
GJE02_RS29370	4785..5582	+	798	WP_046182240.1	sigma 54 modulation/S30EA ribosomal C-terminal domain-containing protein	-
GJE02_RS29375	5651..6040	+	390	Protein_4	pyridoxamine 5'-phosphate oxidase family protein	-
GJE02_RS29380	6269..6553	+	285	WP_082122855.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
GJE02_RS29385	6550..6825	+	276	WP_046182242.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
GJE02_RS29390	6943..7158	-	216	WP_046182243.1	hypothetical protein	-
GJE02_RS29395	7235..7510	+	276	WP_046182244.1	hypothetical protein	-
GJE02_RS29400	7659..8225	+	567	WP_046182262.1	recombinase family protein	-
GJE02_RS30085	8701..9453	+	753	WP_172417609.1	1-aminocyclopropane-1-carboxylate synthase	-
GJE02_RS29410	9687..10643	+	957	WP_082122856.1	fatty acid desaturase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Non-Mobilizable plasmid	-	-	1..39887	39887

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (9-89)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (4-74)

Sequences

Toxin

Protein

• Length: 92 a.a.
• Molecular weight: 10459.92 Da
• Isoelectric Point: 10.0890

>T143176 WP_046182242.1 NZ_CP045965:6550-6825 [Mycobacterium intracellulare subsp. chimaera]
VTDRRYELIIAPTAKKQLAEQLPESAAFAAYEFIIGPLLDNPHRVGKQLRPPLHDRHSARRGTYRVLYRIDDERQQVTVV
GVFSRADAYRA

Nucleotide

• Length: 276 bp

>T143176 NZ_CP060963:1785778-1786029 [Escherichia coli]
ATGCGTACAATTAGCTACAGCGAAGCGCGTCAGAATTTGTCGGCAACAATGATGAAAGCCGTTGAAGATCATGCCCCGAT
CCTTATTACTCGTCAGAATGGAGAGGCTTGTGTTCTGATGTCACTCGAAGAATACAACTCGCTGGAAGAGACGGCTTATC
TACTGCGTTCCCCCGCTAACGCCCGGAGATTGATGGACTCAATCGATAGCCTGAAATCAGGCAAAGGAACAGAAAAGGAC
ATTATTGAGTGA

Antitoxin

Protein

• Length: 95 a.a.
• Molecular weight: 9876.02 Da
• Isoelectric Point: 4.4269

>AT143176 WP_082122855.1 NZ_CP045965:6269-6553 [Mycobacterium intracellulare subsp. chimaera]
MSEVSSLAEAKAHLSELVARVGDQHERITVTVHGRPAAVLLAVDDLESLEETIAVLSDAAALRALAEADAELARGEGENQ
DSLSAAMQARRAKT

Nucleotide

• Length: 285 bp

>AT143176 NZ_CP060963:1786026-1786280 [Escherichia coli]
GTGAAACTAATCTGGTCTGAGGAATCATGGGATGATTATCTGTACTGGCAGGAAACAGATAAGCGAATTGTTAAAAAGAT
CAATGAACTTATCAAAGATACCCGCAGAACGCCATTTGAAGGTAAGGGGAAGCCAGAACCCCTGAAACATAATTTGTCAG
GTTTCTGGTCCCGACGCATTACAGAGGAGCACCGTCTGGTATACGCGGTTACCGACGATTCACTGCTCATTGCAGCATGT
CGTTATCATTATTGA