Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/ParE-RHH
Location 91301..91842 Replicon plasmid pAUSMDU00007395_01
Accession NZ_CP045964
Organism Mycobacterium intracellulare subsp. chimaera strain AUSMDU00007395

Toxin (Protein)


Gene name parE Uniprot ID D5P595
Locus tag GJE02_RS29315 Protein ID WP_007172365.1
Coordinates 91301..91594 (-) Length 98 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID A0A854I1S2
Locus tag GJE02_RS29320 Protein ID WP_040624378.1
Coordinates 91591..91842 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GJE02_RS29285 86631..87062 - 432 WP_139315439.1 hypothetical protein -
GJE02_RS29290 87293..87565 - 273 WP_139315440.1 hypothetical protein -
GJE02_RS29295 87689..88360 - 672 WP_139315441.1 hypothetical protein -
GJE02_RS29300 88470..89549 - 1080 WP_007172361.1 hypothetical protein -
GJE02_RS29305 89664..90362 - 699 WP_139315442.1 hypothetical protein -
GJE02_RS29310 90376..91083 - 708 WP_139315443.1 hypothetical protein -
GJE02_RS29315 91301..91594 - 294 WP_007172365.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
GJE02_RS29320 91591..91842 - 252 WP_040624378.1 type II toxin-antitoxin system ParD family antitoxin Antitoxin
GJE02_RS29325 91948..92454 - 507 WP_007172367.1 helix-turn-helix domain-containing protein -
GJE02_RS29330 92761..93198 + 438 WP_007172368.1 WhiB family transcriptional regulator -
GJE02_RS29335 93254..93844 + 591 WP_023363514.1 hypothetical protein -
GJE02_RS29340 93807..94091 + 285 WP_007172369.1 hypothetical protein -
GJE02_RS29345 94468..96330 + 1863 WP_023363516.1 helicase associated domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - eccA5 / esxN 1..97268 97268


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-92)

Antitoxin

Antitoxin ParD

(2-79)


Sequences

Toxin        


Download         Length: 98 a.a.        Molecular weight: 11261.74 Da        Isoelectric Point: 6.9772

>T143175 WP_007172365.1 NZ_CP045964:c91594-91301 [Mycobacterium intracellulare subsp. chimaera]
VSAYVLSPAAQADLEQIWDYTHEHWGLDQAEQYLRELQRAIERAAANPRIGRACDEIRPGYRKLAAGSHMLFYRVTTQGF
LDVVRVLHQRMDVDRHL

Download         Length: 294 bp

>T143175 NZ_CP060963:958428-958763 [Escherichia coli]
ATGGTAAGCCGATACGTACCCGATATGGGCGATCTGATTTGGGTTGATTTTGACCCGACAAAAGGTAGCGAGCAAGCTCG
ACATCGTCCAGCTGTTGTCCTGAGTCCTTTCATGTACAACAACAAAACAGGTATGTGTCTGTGTGTTCCTTGTACAACGC
AATCAAAAGGATATCCGTTCGAAGTTGTTTTATCCGGTCAGGAACGTGATGGCGTAGCGTTAGCTGATCAGGTAAAAAGT
ATCGCCTGGCGGGCAAGAGGAGCAACGAAGAAAGGAACAGTTGCCCCAGAGGAATTACAACTCATTAAAGCCAAAATTAA
CGTACTGATTGGGTAG

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9203.22 Da        Isoelectric Point: 5.8579

>AT143175 WP_040624378.1 NZ_CP045964:c91842-91591 [Mycobacterium intracellulare subsp. chimaera]
VGKNTSFSLDEHYSAFIEAEVAAGRYRSASDVVRSALRLLEDREIQLRALREALVAGERSGTSTPFDFDAFLDGKRAEKP
QGR

Download         Length: 252 bp

>AT143175 NZ_CP060963:958180-958428 [Escherichia coli]
ATGATCCACAGTAGCGTAAAGCGTTGGGGAAATTCACCGGCGGTGCGGATCCCGACTACGTTAATGCAGGCGCTCAATCT
GAATATTGATGATGAAGTGAAGATTGACCTGGTGGATGGCAAATTAATTATTGAGCCAGTGCGTAAAGAGCCCGTATTTA
CGCTTGCTGAACTGGTCAACGACATCACGCCGGAAAACCTCCACGAGAATATCGACTGGGGAGAGCCGAAAGATAAGGAA
GTCTGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1Y0TBP0

Antitoxin

Source ID Structure
AlphaFold DB A0A854I1S2

References