143173

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/YoeB-YefM
Location 8976..9514 Replicon plasmid pAUSMDU00007395_01
Accession NZ_CP045964
Organism Mycobacterium intracellulare subsp. chimaera strain AUSMDU00007395

Toxin (Protein)


Gene name relE Uniprot ID D5P5D7
Locus tag GJE02_RS28900 Protein ID WP_007172405.1
Coordinates 9257..9514 (+) Length 86 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID M1FTM7
Locus tag GJE02_RS28895 Protein ID WP_007172404.1
Coordinates 8976..9260 (+) Length 95 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GJE02_RS28875 4109..5629 - 1521 WP_007172379.1 DUF4226 domain-containing protein -
GJE02_RS28880 5851..6606 - 756 WP_074021258.1 DUF2637 domain-containing protein -
GJE02_RS28885 7408..8130 + 723 WP_139315444.1 ParA family protein -
GJE02_RS28890 8133..8894 + 762 WP_023363524.1 hypothetical protein -
GJE02_RS28895 8976..9260 + 285 WP_007172404.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
GJE02_RS28900 9257..9514 + 258 WP_007172405.1 Txe/YoeB family addiction module toxin Toxin
GJE02_RS28905 9729..10022 - 294 WP_007172406.1 hypothetical protein -
GJE02_RS28910 10039..11037 - 999 WP_101930848.1 hypothetical protein -
GJE02_RS28915 11749..12318 + 570 WP_007172408.1 hypothetical protein -
GJE02_RS28920 12308..13408 + 1101 WP_007172409.1 tyrosine-type recombinase/integrase -
GJE02_RS28925 13527..13739 + 213 WP_007172410.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - eccA5 / esxN 1..97268 97268


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(4-85)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(2-70)


Sequences

Toxin        


Download         Length: 86 a.a.        Molecular weight: 10156.56 Da        Isoelectric Point: 9.8613

>T143173 WP_007172405.1 NZ_CP045964:9257-9514 [Mycobacterium intracellulare subsp. chimaera]
VRSINFDPAAWEDFLFWLASDRKTARRITRLIAEIQRNPFAGIGKPEPLKGELSGYWSRRIDDEHRIVYRADDHEIKILK
ARYHY

Download         Length: 258 bp

>T143173 NZ_CP060963:712652-712948 [Escherichia coli]
ATGGAAAAACGCACACCACATACACGTTTGAGTCAGGTTAAAAAACTTGTCAATGCCGGGCAAGTTCGTACAACACGTAG
TGCCCTGTTAAATGCAGATGAGTTAGGTTTGGATTTTGATGGTATGTGTAATGTTATCATTGGATTATCAGAGAGCGACT
TTTATAAAAGCATGACCACCTACTCTGATCATACTATCTGGCAGGATGTTTACAGACCCAGGCTTGTTACAGGCCAGGTT
TATCTTAAAATTACGGTAATTCATGACGTACTGATCGTCTCGTTTAAGGAGAAGTAA

Antitoxin


Download         Length: 95 a.a.        Molecular weight: 10455.62 Da        Isoelectric Point: 4.3885

>AT143173 WP_007172404.1 NZ_CP045964:8976-9260 [Mycobacterium intracellulare subsp. chimaera]
MAISASEARQRLFPLLEQVNTDHEPVRITSKAGDAVLMSAADYDSWQETVYLLRSPENARRLMEAVARDNATRPTPGSYT
KSIDELEEMAGGQE

Download         Length: 285 bp

>AT143173 NZ_CP060963:712950-713345 [Escherichia coli]
ATGAAATGTCCGGTTTGCCACCAGGGAGAAATGGTTTCTGGCATTAAAGATATTCCATACACCTTCCGTGGACGAAAAAC
AGTATTGAAAGGTATCCACGGTTTATATTGTGTCCATTGCGAAGAGAGCATCATGAATAAAGAAGAGTCAGATGCTTTCA
TGGCGCAAGTAAAGGCATTTCGGGCTTCGGTGAATGCCGAAACAGTGGCACCTGAATTTATAGTGAAGGTTCGAAAAAAG
CTCTCTCTTACCCAAAAAGAGGCAAGCGAAATTTTTGGGGGAGGTGTAAATGCGTTTTCGCGTTACGAAAAAGGCAATGC
CCAACCTCATCCTTCCACAATCAAACTTTTACGTGTTCTGGATAAGCATCCAGAACTATTGAATGAAATCCGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1Y0THX2

Antitoxin

Source ID Structure
AlphaFold DB M1FTM7

References