143170

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-PHD
Location 2613579..2614243 Replicon chromosome
Accession NZ_CP045963
Organism Mycobacterium intracellulare subsp. chimaera strain AUSMDU00007395

Toxin (Protein)


Gene name vapC Uniprot ID J9WD27
Locus tag GJE02_RS12285 Protein ID WP_009954498.1
Coordinates 2613836..2614243 (+) Length 136 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag GJE02_RS12280 Protein ID WP_009954496.1
Coordinates 2613579..2613839 (+) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GJE02_RS12255 2610088..2610579 - 492 WP_014711439.1 DUF1707 domain-containing protein -
GJE02_RS12260 2610649..2611245 + 597 WP_042911492.1 TetR/AcrR family transcriptional regulator -
GJE02_RS12265 2611250..2612518 - 1269 WP_042911493.1 cytochrome P450 -
GJE02_RS12270 2612676..2613128 + 453 WP_042911495.1 VOC family protein -
GJE02_RS12275 2613199..2613456 + 258 WP_042911496.1 hypothetical protein -
GJE02_RS12280 2613579..2613839 + 261 WP_009954496.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
GJE02_RS12285 2613836..2614243 + 408 WP_009954498.1 type II toxin-antitoxin system VapC family toxin Toxin
GJE02_RS12290 2614421..2617522 + 3102 WP_042911498.1 DEAD/DEAH box helicase -
GJE02_RS12295 2617584..2619149 - 1566 WP_042911499.1 serine/threonine protein kinase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(9-125)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-66)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 14293.28 Da        Isoelectric Point: 4.2772

>T143170 WP_009954498.1 NZ_CP045963:2613836-2614243 [Mycobacterium intracellulare subsp. chimaera]
MSNPQVAGVLDTSVFIATESGRPLDAALIPDQVGTTVVTLAELHVGVLAASTSDIRAQRLATLESIADIEALPVDDDAAR
MWARLRIHLAETGQRVRINDLWIAAIAASRGLPVVTQDDDFAVLDGAANLTVIRV

Download         Length: 408 bp

>T143170 NZ_CP060963:183345-183452 [Escherichia coli]
ATGACGTTCGCAGAGCTGGGCATGGCCTTCTGGCATGATTTAGCGGCTCCGGTCATTGCTGGCATTCTTGCCAGTATGAT
CGTGAACTGGCTGAACAAGCGGAAGTAA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9526.85 Da        Isoelectric Point: 9.1203

>AT143170 WP_009954496.1 NZ_CP045963:2613579-2613839 [Mycobacterium intracellulare subsp. chimaera]
MSEVASRELRNDTAGVLRRVRDGEDVTITVSGRPVAVLTAVVPQRRRWLSKTELLSRLPRVQADPGLREDLHALAGDTTE
ELGPIR

Download         Length: 261 bp

>AT143170 NZ_CP060963:c183297-183231 [Escherichia coli]
GGTCTAGAGTCAAGATTAGCCCCCGTGGTGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB J9WD27

Antitoxin

Source ID Structure

References