143168

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VapB
Location 1601939..1602501 Replicon chromosome
Accession NZ_CP045963
Organism Mycobacterium intracellulare subsp. chimaera strain AUSMDU00007395

Toxin (Protein)


Gene name vapC Uniprot ID A0A081I0A5
Locus tag GJE02_RS07940 Protein ID WP_036454801.1
Coordinates 1602133..1602501 (+) Length 123 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A081I0A4
Locus tag GJE02_RS07935 Protein ID WP_036455532.1
Coordinates 1601939..1602136 (+) Length 66 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GJE02_RS07900 1597043..1598188 - 1146 WP_179945068.1 hypothetical protein -
GJE02_RS07905 1598318..1599391 + 1074 WP_042910932.1 redox-regulated ATPase YchF -
GJE02_RS07910 1599408..1600148 + 741 WP_042910933.1 aminoglycoside 3'-phosphotransferase -
GJE02_RS07915 1600236..1600520 + 285 WP_020821851.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
GJE02_RS07920 1600535..1600780 + 246 WP_042910934.1 type II toxin-antitoxin system RelE/ParE family toxin -
GJE02_RS07925 1600816..1601367 + 552 WP_036454798.1 VOC family protein -
GJE02_RS07930 1601446..1601844 + 399 WP_036454800.1 VOC family protein -
GJE02_RS07935 1601939..1602136 + 198 WP_036455532.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
GJE02_RS07940 1602133..1602501 + 369 WP_036454801.1 type II toxin-antitoxin system VapC family toxin Toxin
GJE02_RS07945 1602684..1603025 + 342 WP_172417493.1 hypothetical protein -
GJE02_RS29950 1603111..1603470 + 360 WP_042910935.1 hypothetical protein -
GJE02_RS07955 1603655..1604230 + 576 WP_075630262.1 C40 family peptidase -
GJE02_RS07960 1604593..1604916 + 324 WP_036454806.1 antibiotic biosynthesis monooxygenase -
GJE02_RS07965 1604954..1605787 - 834 WP_036454808.1 SAM-dependent methyltransferase -
GJE02_RS07970 1605822..1606505 - 684 WP_036455537.1 hypothetical protein -
GJE02_RS07975 1606652..1606861 + 210 WP_072501223.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-111)

Antitoxin

Bacterial antitoxin of type II TA system, VapB

(1-42)


Sequences

Toxin        


Download         Length: 123 a.a.        Molecular weight: 13435.74 Da        Isoelectric Point: 6.4862

>T143168 WP_036454801.1 NZ_CP045963:1602133-1602501 [Mycobacterium intracellulare subsp. chimaera]
MILVDTAVWIDHLHTAELRLVKLLEIDQVGCHALVIEELALGSISRREVVLDLLANLRQFPTVQHAEILHLTGQRKLYGR
GLSAVDVHLMAAVALVEGAQLWTRDKRLKAASVDAGIALFDA

Download         Length: 369 bp

>T143168 NZ_CP060954:c14266-13916 [Escherichia coli]
ATGTGGGTCATCGAGACAACCGACACCTTTGATGAGTGGTTCGATGCTCTGGATGATACCGATAGAGCAAACGTGCTGGC
TTCGATGATGGTGCTGCGAGATAGAGGCCCCATGCTGTCGAGGCCATACGCGGATACTGTTAACGGTTCATCCTACAGCA
ACATGAAAGAGCTTCGGGTCCAAAGCAAAGGAGATCCTATCAGAGCGTTCTTTGCGTTCGATCCAAAGCGTAAGGGGATT
CTTCTCTGCGCCGGTAACAAGACCGGGGACGAGAAAAGGTTTTATGAAGTAATGATCCCAATTGCAGACCGTGAGTTTGC
GGCGCACTTGGATAAATTGAAGAAGGAGTGA

Antitoxin


Download         Length: 66 a.a.        Molecular weight: 6871.88 Da        Isoelectric Point: 11.6072

>AT143168 WP_036455532.1 NZ_CP045963:1601939-1602136 [Mycobacterium intracellulare subsp. chimaera]
MRTTVTIDDDLLAKAAELTGVRENVALLREGLQTLIRVESARRLAALGGTDAGAVAAPRRRRGTG

Download         Length: 198 bp

>AT143168 NZ_CP060954:c13911-13609 [Escherichia coli]
ATGGCAAGAACTCTTGACCAAATGCTGGCAACAGAAAAGCCTGAGGTTGTTGCCAAAGCACAGAAAGCGGCCACTGAGAT
GTTACTGAACATCCACTTGGCAGAGCTTCGTGATCGCATGAACCTTACCCAGGGGGAAATTGCTGCATCTCTGGGTGTGA
GACAGCCGACAGTCTCCGAGATGGAAAAACCTGGACGAGATCTCAAGCTGTCGTCCATTAAGCGGTACGTTGAGGCCTCC
GGTGGCAAGCTACGCCTCGATGTTGAACTTCCGGACGGCACCCACTACGGCTTTGCCGTTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A081I0A5

Antitoxin

Source ID Structure
AlphaFold DB A0A081I0A4

References