Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE-Phd
Location 1600236..1600780 Replicon chromosome
Accession NZ_CP045963
Organism Mycobacterium intracellulare subsp. chimaera strain AUSMDU00007395

Toxin (Protein)


Gene name relE Uniprot ID A0A854HUL3
Locus tag GJE02_RS07920 Protein ID WP_042910934.1
Coordinates 1600535..1600780 (+) Length 82 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID S4Z4W6
Locus tag GJE02_RS07915 Protein ID WP_020821851.1
Coordinates 1600236..1600520 (+) Length 95 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GJE02_RS07890 1595310..1595909 - 600 WP_009953444.1 lipid droplet-associated protein -
GJE02_RS07895 1595999..1596997 + 999 WP_042910931.1 4-hydroxy-3-methylbut-2-enyl diphosphate reductase -
GJE02_RS07900 1597043..1598188 - 1146 WP_179945068.1 hypothetical protein -
GJE02_RS07905 1598318..1599391 + 1074 WP_042910932.1 redox-regulated ATPase YchF -
GJE02_RS07910 1599408..1600148 + 741 WP_042910933.1 aminoglycoside 3'-phosphotransferase -
GJE02_RS07915 1600236..1600520 + 285 WP_020821851.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
GJE02_RS07920 1600535..1600780 + 246 WP_042910934.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
GJE02_RS07925 1600816..1601367 + 552 WP_036454798.1 VOC family protein -
GJE02_RS07930 1601446..1601844 + 399 WP_036454800.1 VOC family protein -
GJE02_RS07935 1601939..1602136 + 198 WP_036455532.1 type II toxin-antitoxin system VapB family antitoxin -
GJE02_RS07940 1602133..1602501 + 369 WP_036454801.1 type II toxin-antitoxin system VapC family toxin -
GJE02_RS07945 1602684..1603025 + 342 WP_172417493.1 hypothetical protein -
GJE02_RS29950 1603111..1603470 + 360 WP_042910935.1 hypothetical protein -
GJE02_RS07955 1603655..1604230 + 576 WP_075630262.1 C40 family peptidase -
GJE02_RS07960 1604593..1604916 + 324 WP_036454806.1 antibiotic biosynthesis monooxygenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(29-80)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-71)


Sequences

Toxin        


Download         Length: 82 a.a.        Molecular weight: 9380.95 Da        Isoelectric Point: 11.2612

>T143167 WP_042910934.1 NZ_CP045963:1600535-1600780 [Mycobacterium intracellulare subsp. chimaera]
MTAAAKRALTHLLPESVAIACWEFIRGPLAENPQRVGKPLRGQLEGRYSARRGEFRVIYRIFDERVVVPVIHIAHRRDVY
R

Download         Length: 246 bp

>T143167 NZ_CP060953:c4972706-4972599 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCATGATTTTCTGGCACGACCTGGCAGCACCGATCCTGGCGGGAATTATTACCGCAGCGAT
TGTCGGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 95 a.a.        Molecular weight: 10513.88 Da        Isoelectric Point: 4.3705

>AT143167 WP_020821851.1 NZ_CP045963:1600236-1600520 [Mycobacterium intracellulare subsp. chimaera]
MSTLPLAEVRANLSKLVDEAVRTHERIEVTRQGRRAAVILSADDFDSIMETLAILSDQDLMREVRAAESEAEDGALYTLD
QVTEEMRAVGRLPR

Download         Length: 285 bp

>AT143167 NZ_CP060953:4972759-4972820 [Escherichia coli]
TGGTTCAAGATTAGCCCCCGTTCTGTTGTCAGGTTTTACCTCTCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A854HUL3

Antitoxin

Source ID Structure
AlphaFold DB S4Z4W6

References