Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN-PHD
Location 1072136..1072803 Replicon chromosome
Accession NZ_CP045963
Organism Mycobacterium intracellulare subsp. chimaera strain AUSMDU00007395

Toxin (Protein)


Gene name vapC Uniprot ID D5PE24
Locus tag GJE02_RS05275 Protein ID WP_007168407.1
Coordinates 1072411..1072803 (+) Length 131 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID D5PE23
Locus tag GJE02_RS05270 Protein ID WP_007168406.1
Coordinates 1072136..1072411 (+) Length 92 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GJE02_RS30110 1067640..1067966 - 327 WP_033711234.1 hypothetical protein -
GJE02_RS05240 1067956..1068189 - 234 Protein_1031 transposase -
GJE02_RS05245 1068207..1069418 - 1212 Protein_1032 ISL3 family transposase -
GJE02_RS05250 1069557..1070189 - 633 Protein_1033 DDE-type integrase/transposase/recombinase -
GJE02_RS05255 1070141..1070281 - 141 WP_145958858.1 SDR family oxidoreductase -
GJE02_RS05260 1070325..1071028 - 704 Protein_1035 histidine phosphatase family protein -
GJE02_RS05265 1071111..1071983 + 873 WP_007168405.1 MaoC family dehydratase N-terminal domain-containing protein -
GJE02_RS05270 1072136..1072411 + 276 WP_007168406.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
GJE02_RS05275 1072411..1072803 + 393 WP_007168407.1 type II toxin-antitoxin system VapC family toxin Toxin
GJE02_RS05280 1072951..1074110 - 1160 Protein_1039 trehalose-phosphatase -
GJE02_RS05285 1074152..1075490 - 1339 Protein_1040 DUF1298 domain-containing protein -
GJE02_RS05290 1075752..1075874 - 123 Protein_1041 IS1595 family transposase -
GJE02_RS05295 1076210..1077544 + 1335 Protein_1042 IS1182 family transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(4-119)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-45)


Sequences

Toxin        


Download         Length: 131 a.a.        Molecular weight: 14305.73 Da        Isoelectric Point: 10.5032

>T143164 WP_007168407.1 NZ_CP045963:1072411-1072803 [Mycobacterium intracellulare subsp. chimaera]
MAAIYLDSSAIVKLAVREPESDALRRYLRTRLPRVSSALARTEVMRALLHKGESARRAGRRALASLDLLRIDNRLLDLAG
GLLPIELRTLDAIHLATAQRLGMDLGRLCTYDDRMRDAAEALGMAVIAPS

Download         Length: 393 bp

>T143164 NZ_CP060953:3942429-3942827 [Escherichia coli]
ATGCGGGTATTCAAAACAAAACTTATTCGCCTGCAACTTACAGCAGAGGAACTTGAAGCGTTAACGGCGGATTTTATTTC
CTATAAGCGTGACGGTGTTTTGCCAGATATATTTGGTCGTGATGCACTCTACGACGACTCGTTTACCTGGCCATTAATCA
AATTTGAGCGAGTTGCTCATATTCATCTGGCAAATGTGAATAATCCATTTCCGCCACAGTTGCGCCAATTCAGCAGAACG
AATGACGCAGCGCATTTGGTATATTGTCAGGGCGCGTTTGATGAGCAAGCATGGTTGCTCATTGCCATTCTGAAACCTGA
ACCTCATAAACTGGCTCGAGATAACAACCAAATGCATAAAATTGGGAAAATGGCAGAAGCGTTTCGCATGCGTTTTTGA

Antitoxin


Download         Length: 92 a.a.        Molecular weight: 10150.63 Da        Isoelectric Point: 5.1881

>AT143164 WP_007168406.1 NZ_CP045963:1072136-1072411 [Mycobacterium intracellulare subsp. chimaera]
MSTVGVRELRQRASELLRRVEAGETIEITDRGRPIALLSPMPEGGPYQQMLASGGIERATLDFDDLPEPVRLKTGIELPS
VTLARLREHER

Download         Length: 276 bp

>AT143164 NZ_CP060953:3942133-3942426 [Escherichia coli]
ATGCATCGAATTCTCGCTGAAAAATCGGTCAATATCACTGAGTTACGTAAAAACCCAGCTAAATACTTTATTGATCAACC
TGTTGCGGTTCTTTCTAATAATCGCCCCGCAGGATATCTCTTAAGTGCCAGCGCATTTGAAGCATTAATGGACATGCTTG
CAGAACAAGAGGAGAAAAAGCCCATAAAGGCGCGCTTCCGTCCGAGTGCTGCAAGATTAGAGGAAATTACACGCCGCGCT
GAACAATATCTTAATGATATGACGGATGATGATTTCAATGACTTTAAGGAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1X1XV84

Antitoxin

Source ID Structure
AlphaFold DB A0A1X1XUZ3

References