Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mbcAT/RES-TIGR02293
Location 287949..288847 Replicon chromosome
Accession NZ_CP045963
Organism Mycobacterium intracellulare subsp. chimaera strain AUSMDU00007395

Toxin (Protein)


Gene name mbcT Uniprot ID A0A7I9ZD82
Locus tag GJE02_RS01405 Protein ID WP_042910420.1
Coordinates 287949..288509 (-) Length 187 a.a.

Antitoxin (Protein)


Gene name mbcA Uniprot ID A0A7I9ZDJ0
Locus tag GJE02_RS01410 Protein ID WP_042910421.1
Coordinates 288506..288847 (-) Length 114 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GJE02_RS01385 284829..285314 + 486 WP_051445817.1 hypothetical protein -
GJE02_RS01390 285586..285822 + 237 WP_142383091.1 hypothetical protein -
GJE02_RS01395 286482..286664 - 183 WP_042910451.1 antitoxin VbhA family protein -
GJE02_RS01400 286768..287772 - 1005 WP_042910419.1 tyrosine-type recombinase/integrase -
GJE02_RS01405 287949..288509 - 561 WP_042910420.1 RES domain-containing protein Toxin
GJE02_RS01410 288506..288847 - 342 WP_042910421.1 DUF2384 domain-containing protein Antitoxin
GJE02_RS01415 288934..290087 + 1154 Protein_274 hypothetical protein -
GJE02_RS01420 290265..291259 - 995 Protein_275 IS481 family transposase -
GJE02_RS01425 292295..292927 - 633 WP_042910422.1 CAP domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

RES domain

(25-148)

Antitoxin

Antitoxin Xre/MbcA/ParS-like, toxin-binding domain

(69-110)


Sequences

Toxin        


Download         Length: 187 a.a.        Molecular weight: 20501.00 Da        Isoelectric Point: 5.8540

>T143162 WP_042910420.1 NZ_CP045963:c288509-287949 [Mycobacterium intracellulare subsp. chimaera]
VSDALDEGLVQRIDACGTTPWSGTCYRYTTAHRDALSGEGARRFGGRWNPPLLFPAIYLADSAKACMVEVERAANAASTT
AIKMLEAAYRLHHIQVEELNVLDLRTPESRDAVGLDDDDVYGDDWSACQAVGHTAWFLHMQGILVPAAGGIGLVISAYEQ
RTRPRQLHLRHSENLTPALYTQYRSS

Download         Length: 561 bp

>T143162 NZ_CP060953:c3630930-3630778 [Escherichia coli]
ATGAAGCAGCATAAGGCGATGATTGTCGCCCTGATCGTCATCTGTATCACCGCCGTAGTGGCGGCGCTGGTAACGAGAAA
AGACCTCTGTGAGGTTCACATCCGAACTGGCCAGACGGAGGTTGCTGTTTTCACGGCTTACGAATCCGAGTAA

Antitoxin


Download         Length: 114 a.a.        Molecular weight: 12612.51 Da        Isoelectric Point: 4.8483

>AT143162 WP_042910421.1 NZ_CP045963:c288847-288506 [Mycobacterium intracellulare subsp. chimaera]
MAMNALASTVSSAIERLGLTYEEVGDIVEASPRSVARWTSGQVVPQRLNKQRLIELAYVADALAEVLPRDQANMWMFSPN
RLLEHRKPADLIRDGEYQRVLALIDAMAEGVFV

Download         Length: 342 bp

>AT143162 NZ_CP060953:3630979-3631036 [Escherichia coli]
GTTCTGCATATAGGGGGCCTCGGGTTGATGGTAAAATATCACTCGGGGCTTTTCTCTA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7I9ZD82

Antitoxin

Source ID Structure
AlphaFold DB A0A7I9ZDJ0

References