Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 3705586..3706260 Replicon chromosome
Accession NZ_CP045962
Organism Mycobacterium tuberculosis strain AUSMDU00018547

Toxin (Protein)


Gene name vapC Uniprot ID P9WF52
Locus tag GJE03_RS17470 Protein ID WP_003417282.1
Coordinates 3705586..3706014 (-) Length 143 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID G0TI59
Locus tag GJE03_RS17475 Protein ID WP_003417286.1
Coordinates 3706018..3706260 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GJE03_RS17445 3701408..3701809 - 402 WP_003417264.1 cytidine deaminase -
GJE03_RS17450 3701950..3702384 + 435 WP_072460198.1 succinate dehydrogenase, cytochrome b556 subunit -
GJE03_RS17455 3702381..3702815 + 435 WP_003417269.1 succinate dehydrogenase hydrophobic membrane anchor subunit -
GJE03_RS17460 3702944..3704716 + 1773 WP_003417273.1 succinate dehydrogenase flavoprotein subunit -
GJE03_RS17465 3704716..3705507 + 792 WP_003417279.1 succinate dehydrogenase iron-sulfur subunit -
GJE03_RS17470 3705586..3706014 - 429 WP_003417282.1 type II toxin-antitoxin system VapC family toxin Toxin
GJE03_RS17475 3706018..3706260 - 243 WP_003417286.1 ribbon-helix-helix domain-containing protein Antitoxin
GJE03_RS17480 3706382..3706996 - 615 WP_003417288.1 class I SAM-dependent methyltransferase -
GJE03_RS17485 3706993..3707658 - 666 WP_003417290.1 molybdopterin converting factor subunit 1 -
GJE03_RS17490 3707659..3708192 - 534 WP_003417293.1 cyclic pyranopterin monophosphate synthase MoaC -
GJE03_RS17495 3708189..3708563 - 375 WP_003417295.1 4a-hydroxytetrahydrobiopterin dehydratase -
GJE03_RS17500 3708660..3709724 - 1065 WP_003913037.1 GTP 3',8-cyclase MoaA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain toxin

(1-141)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 143 a.a.        Molecular weight: 15834.16 Da        Isoelectric Point: 8.5471

>T143158 WP_003417282.1 NZ_CP045962:c3706014-3705586 [Mycobacterium tuberculosis]
MRALLDVNVLLALLDRDHVDHERARAWITGQIERGWASCAITQNGFVRVISQPRYPSPISVAHAIDLLARATHTRYHEFW
SCTVSILDSKVIDRSRLHSPKQVTDAYLLALAVAHDGRFVTFDQSIALTAVPGATKQHLATL

Download         Length: 429 bp

>T143158 NZ_CP060953:3243957-3244130 [Escherichia coli]
ATGGCACTATTCTCTAAAATATTAATTTTTTATGTGATTGGTGTGAACATATCCTTTGTCATTATCTGGTTTATCTCACA
TGAGAAAACACATATTCGTTTACTTAGTGCATTTCTGGTCGGAATAACCTGGCCAATGAGTCTTCCTGTGGCATTACTTT
TTTCTCTCTTTTAG

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8849.86 Da        Isoelectric Point: 5.1007

>AT143158 WP_003417286.1 NZ_CP045962:c3706260-3706018 [Mycobacterium tuberculosis]
MRTTLSIDDDVLLAVKERARREKRTAGEILSDLARQALTNQNPQPAASQEDAFHGFEPLPHRGGAVSNALIDRLRDEEAV

Download         Length: 243 bp

>AT143158 NZ_CP060953:3243633-3243929 [Escherichia coli]
ATGGAAGGTAAAAACAAGTTCAATACTTATGTTGTTTCTTTTGATTATCCATCATCTTATTCCTCAGTGTTCTTAAGGTT
AAGATCATTGATGTATGATATGAATTTCTCCTCTATCGTGGCTGATGAATATGGGATACCACGACAACTGAATGAAAACT
CCTTCGCAATAACGACATCGTTAGCCGCAAGTGAAATCGAAGATTTAATCAGGCTCAAATGCTTAGACTTACCGGATATT
GATTTTGACCTCAGCATTATGACAGTTGATGACTATTTCCGTCAGTTTTACAAGTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U4FBL0

Antitoxin

Source ID Structure
AlphaFold DB G0TI59

References