143144

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/-
Location 2411187..2411716 Replicon chromosome
Accession NZ_CP045962
Organism Mycobacterium tuberculosis strain AUSMDU00018547

Toxin (Protein)


Gene name parE Uniprot ID G0TMR4
Locus tag GJE03_RS11230 Protein ID WP_003411124.1
Coordinates 2411187..2411504 (-) Length 106 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID P9WJ74
Locus tag GJE03_RS11235 Protein ID WP_003411127.1
Coordinates 2411501..2411716 (-) Length 72 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GJE03_RS11200 2406324..2407400 + 1077 WP_003904789.1 hypothetical protein -
GJE03_RS11205 2407397..2407678 + 282 WP_003411112.1 hypothetical protein -
GJE03_RS11210 2407714..2408787 + 1074 WP_003411116.1 quinone-dependent dihydroorotate dehydrogenase -
GJE03_RS11215 2408792..2409322 - 531 WP_003903767.1 YbhB/YbcL family Raf kinase inhibitor-like protein -
GJE03_RS11220 2409370..2410716 - 1347 WP_003411121.1 M20/M25/M40 family metallo-hydrolase -
GJE03_RS11230 2411187..2411504 - 318 WP_003411124.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
GJE03_RS11235 2411501..2411716 - 216 WP_003411127.1 antitoxin ParD2 Antitoxin
GJE03_RS11240 2411971..2413029 + 1059 WP_003411129.1 hypothetical protein -
GJE03_RS11245 2413159..2413515 - 357 WP_003411130.1 hypothetical protein -
GJE03_RS11250 2413610..2414392 - 783 WP_003411131.1 cell wall synthesis protein Wag31 -
GJE03_RS11255 2414660..2414950 - 291 WP_003900476.1 YggT family protein -
GJE03_RS11260 2415112..2415768 - 657 WP_003411133.1 cell division protein SepF -
GJE03_RS11265 2415834..2416610 - 777 WP_003411137.1 YggS family pyridoxal phosphate-dependent enzyme -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-92)

Antitoxin

Conserved hypothetical protein CHP02574, addiction module

(11-69)


Sequences

Toxin        


Download         Length: 106 a.a.        Molecular weight: 12312.88 Da        Isoelectric Point: 6.4831

>T143144 WP_003411124.1 NZ_CP045962:c2411504-2411187 [Mycobacterium tuberculosis]
MTRRLRVHNGVEDDLFEAFSYYADAAPDQIDRLYNLFVDAVTKRIPQAPNAFAPLFKHYRHIYLRPFRYYVAYRTTDEAI
DILAVRHGMENPNAVEAEISGRTFE

Download         Length: 318 bp

>T143144 NZ_CP060950:c4865171-4864917 [Escherichia coli]
GTGAAACTAATCTGGTCTGAGGAATCATGGGATGATTATCTGTACTGGCAGGAAACAGATAAGCGAATTGTTAAAAAGAT
CAATGAACTTATCAAAGATACCCGCAGAACGCCATTTGAAGGTAAGGGGAAGCCAGAACCCCTGAAACATAATTTGTCAG
GTTTCTGGTCCCGACGCATTACAGAGGAGCACCGTCTGGTATACGCGGTTACCGACGATTCACTGCTCATTGCAGCATGT
CGTTATCATTATTGA

Antitoxin


Download         Length: 72 a.a.        Molecular weight: 7880.70 Da        Isoelectric Point: 4.4055

>AT143144 WP_003411127.1 NZ_CP045962:c2411716-2411501 [Mycobacterium tuberculosis]
VVVNRALLASVDALSRDEQIELVEHINGNLAEGMHISEANQALIEARANDTDDAHWSTIDDFDKRIRARLG

Download         Length: 216 bp

>AT143144 NZ_CP060950:c4865419-4865168 [Escherichia coli]
ATGCGTACAATTAGCTACAGCGAAGCGCGTCAGAATTTGTCGGCAACAATGATGAAAGCCGTTGAAGATCATGCCCCGAT
CCTTATTACTCGTCAGAATGGAGAGGCTTGTGTTCTGATGTCACTCGAAGAATACAACTCGCTGGAAGAGACGGCTTATC
TACTGCGTTCCCCCGCTAACGCCCGGAGATTGATGGACTCAATCGATAGCCTGAAATCAGGCAAAGGAACAGAAAAGGAC
ATTATTGAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G0TMR4

Antitoxin

Source ID Structure
AlphaFold DB A0A7U4FAJ4

References