143140

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VapB
Location 2263434..2264060 Replicon chromosome
Accession NZ_CP045962
Organism Mycobacterium tuberculosis strain AUSMDU00018547

Toxin (Protein)


Gene name vapC Uniprot ID P64926
Locus tag GJE03_RS10545 Protein ID WP_003410075.1
Coordinates 2263662..2264060 (+) Length 133 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A806JLL8
Locus tag GJE03_RS10540 Protein ID WP_003911750.1
Coordinates 2263434..2263661 (+) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GJE03_RS10530 2261473..2261817 - 345 WP_003410065.1 ferredoxin family protein -
GJE03_RS10535 2262006..2263175 - 1170 WP_003899126.1 ATP-binding protein -
GJE03_RS10540 2263434..2263661 + 228 WP_003911750.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
GJE03_RS10545 2263662..2264060 + 399 WP_003410075.1 PIN domain nuclease Toxin
GJE03_RS10550 2264243..2264674 - 432 WP_154079960.1 MarR family winged helix-turn-helix transcriptional regulator -
GJE03_RS10555 2264775..2265209 + 435 WP_003914358.1 DUF1398 domain-containing protein -
GJE03_RS10560 2265646..2265825 - 180 Protein_2070 hypothetical protein -
GJE03_RS10565 2265886..2266533 + 648 WP_071854215.1 transposase -
GJE03_RS10570 2266487..2267077 + 591 WP_003899131.1 IS110 family transposase -
GJE03_RS10575 2267205..2268461 - 1257 WP_003902247.1 HNH endonuclease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(1-120)

Antitoxin

Bacterial antitoxin of type II TA system, VapB

(2-43)


Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 14731.02 Da        Isoelectric Point: 6.7067

>T143140 WP_003410075.1 NZ_CP045962:2263662-2264060 [Mycobacterium tuberculosis]
MIVDTSVWIAYLSTSESLASRWLADRIAADSTVIVPEVVMMELLIGKTDEDTAALRRRLLQRFAIEPLAPVRDAEDAAAI
HRRCRRGGDTVRSLIDCQVAAMALRIGVAVAHRDRDYEAIRTHCGLRTEPLF

Download         Length: 399 bp

>T143140 NZ_CP060950:c4047072-4046965 [Escherichia coli]
ATGACGCTCGCGAAGTTTGCCATGATTTTCTGGCACGACCTGGCAGCACCGATCCTGGCGGGGATTATTACCGCAGCGAT
TGTCGGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8346.16 Da        Isoelectric Point: 4.1621

>AT143140 WP_003911750.1 NZ_CP045962:2263434-2263661 [Mycobacterium tuberculosis]
VSRTNIEIDDELVAAAQRMYRLDSKRSAVDLALRRLVGEPLGRDEALALQGSGFDFSNDEIESFSDTDRKLADES

Download         Length: 228 bp

>AT143140 NZ_CP060950:4047125-4047186 [Escherichia coli]
TGGTTCAAGATTAGCCCCCGTTCTGTTGTCAGGTTTTACCTCTCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4CHG

Antitoxin

Source ID Structure
AlphaFold DB A0A806JLL8

References