143139

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 2239694..2240280 Replicon chromosome
Accession NZ_CP045962
Organism Mycobacterium tuberculosis strain AUSMDU00018547

Toxin (Protein)


Gene name mazF Uniprot ID G0TLY3
Locus tag GJE03_RS10445 Protein ID WP_003410010.1
Coordinates 2239694..2240038 (-) Length 115 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID P0CL58
Locus tag GJE03_RS10450 Protein ID WP_003410014.1
Coordinates 2240032..2240280 (-) Length 83 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GJE03_RS10410 2235400..2235999 + 600 WP_003409989.1 L-lysine exporter -
GJE03_RS10415 2236415..2236843 + 429 WP_003409992.1 cellulose-binding protein -
GJE03_RS10420 2237069..2237608 + 540 WP_003900446.1 23S rRNA (adenine(2058)-N(6))-methyltransferase Erm(37) -
GJE03_RS10425 2238128..2238688 - 561 WP_003410001.1 RES family NAD+ phosphorylase -
GJE03_RS10430 2238685..2239026 - 342 WP_003410003.1 DUF2384 domain-containing protein -
GJE03_RS10435 2239112..2239369 + 258 WP_003410006.1 hypothetical protein -
GJE03_RS10440 2239270..2239605 - 336 WP_003410009.1 dehydrogenase -
GJE03_RS10445 2239694..2240038 - 345 WP_003410010.1 type II toxin-antitoxin system toxin endoribonuclease MazF6 Toxin
GJE03_RS10450 2240032..2240280 - 249 WP_003410014.1 ribbon-helix-helix protein, CopG family Antitoxin
GJE03_RS10455 2240380..2242695 - 2316 WP_003899120.1 cation transporter ATPase CptG -
GJE03_RS10460 2242692..2242964 - 273 WP_003903706.1 DUF1490 family protein -
GJE03_RS10465 2243017..2243373 - 357 WP_003410018.1 Cd(II)/Pb(II)-sensing metalloregulatory transcriptional regulator CmtR -
GJE03_RS10470 2243530..2244297 + 768 WP_003410019.1 hemerythrin domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(5-112)

Antitoxin

Ribbon-helix-helix protein, CopG

(5-38)


Sequences

Toxin        


Download         Length: 115 a.a.        Molecular weight: 12230.12 Da        Isoelectric Point: 9.8887

>T143139 WP_003410010.1 NZ_CP045962:c2240038-2239694 [Mycobacterium tuberculosis]
VVISRAEIYWADLGPPSGSQPAKRRPVLVIQSDPYNASRLATVIAAVITSNTALAAMPGNVFLPATTTRLPRDSVVNVTA
IVTLNKTDLTDRVGEVPASLMHEVDRGLRRVLDL

Download         Length: 345 bp

>T143139 NZ_CP060950:c4046537-4046430 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCATGATTTTCTGGCACGACCTGGCAGCACCGATCCTGGCGGGAATTATTACCGCAGCGAT
TGTCGGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 9290.34 Da        Isoelectric Point: 4.3757

>AT143139 WP_003410014.1 NZ_CP045962:c2240280-2240032 [Mycobacterium tuberculosis]
MKTAISLPDETFDRVSRRASELGMSRSEFFTKAAQRYLHELDAQLLTGQIDRALESIHGTDEAEALAVANAYRVLETMDD
EW

Download         Length: 249 bp

>AT143139 NZ_CP060950:4046587-4046650 [Escherichia coli]
TCTGGTTCAAGATTAGCCCCCGTTCTGTTGTCAGGTTAAACCTCTCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 5HK3
PDB 5HK0
PDB 5HKC

Antitoxin

Source ID Structure
AlphaFold DB A0A7U4FAW9

References