143137

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC(toxin)
Location 2230802..2231490 Replicon chromosome
Accession NZ_CP045962
Organism Mycobacterium tuberculosis strain AUSMDU00018547

Toxin (Protein)


Gene name vapC Uniprot ID P0A653
Locus tag GJE03_RS10380 Protein ID WP_003409958.1
Coordinates 2230802..2231221 (-) Length 140 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID P9WJ28
Locus tag GJE03_RS10385 Protein ID WP_003409968.1
Coordinates 2231230..2231490 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GJE03_RS10360 2226297..2227145 + 849 WP_154079957.1 class I SAM-dependent methyltransferase -
GJE03_RS10365 2227108..2228553 - 1446 WP_003409946.1 APC family permease -
GJE03_RS10370 2228732..2229418 - 687 WP_003409954.1 immunoprotective protein Mpt64 -
GJE03_RS10375 2229609..2230577 - 969 WP_003899116.1 class 1b ribonucleoside-diphosphate reductase subunit beta -
GJE03_RS10380 2230802..2231221 - 420 WP_003409958.1 type II toxin-antitoxin system VapC family toxin Toxin
GJE03_RS10385 2231230..2231490 - 261 WP_003409968.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
GJE03_RS10390 2231633..2233309 + 1677 WP_154079958.1 PecA family PE domain-processing aspartic protease -
GJE03_RS10395 2233297..2233950 - 654 WP_003409976.1 cutinase Cfp21 -
GJE03_RS10400 2234065..2234295 + 231 WP_003409980.1 DUF167 domain-containing protein -
GJE03_RS10405 2234380..2235291 - 912 WP_003409986.1 ArgP/LysG family DNA-binding transcriptional regulator -
GJE03_RS10410 2235400..2235999 + 600 WP_003409989.1 L-lysine exporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(1-125)

Antitoxin

Antitoxin VapB-like

(2-81)


Sequences

Toxin        


Download         Length: 140 a.a.        Molecular weight: 14724.89 Da        Isoelectric Point: 7.9535

>T143137 WP_003409958.1 NZ_CP045962:c2231221-2230802 [Mycobacterium tuberculosis]
MIVDTSAVVALVQGERPHATLVAAALAGAHSPVMSAPTVAECLIVLTARHGPVARTIFERLRSEIGLSVSSFTAEHAAAT
QRAFLRYGKGRHRAALNFGDCMTYATAQLGHQPLLAVGNDFPQTDLEFRGVVGYWPGVA

Download         Length: 420 bp

>T143137 NZ_CP060950:c3263496-3263278 [Escherichia coli]
ATGTCCGAAAAACCTTTAACGAAAACCGATTATTTAATGCGTTTACGTCGTTGCCAGACAATTGACACGCTGGAGCGTGT
TATCGAGAAAAATAAATACGAATTATCAGATAATGAACTGGCGGTATTTTACTCAGCCGCAGATCACCGCCTCGCCGAAT
TGACCATGAATAAACTATACGACAAGATCCCTTCCTCAGTATGGAAATTTATTCGCTAA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9528.88 Da        Isoelectric Point: 5.1007

>AT143137 WP_003409968.1 NZ_CP045962:c2231490-2231230 [Mycobacterium tuberculosis]
VALNIKDPEVDRLAAELADRLHTSKTAAIRHALSAQLAFLESRAGDREAQLLDILRTEIWPLLADRSPITKLEREQILGY
DPATGV

Download         Length: 261 bp

>AT143137 NZ_CP060950:c3263896-3263522 [Escherichia coli]
ATGGATGAATACTCACCCAAAAGACATGATATCGCACAGCTTAAGTTTCTCTGTGAAACCCTGTATCATGACTGCCTTGC
AAACCTTGAAGAAAGCAATCATGGCTGGGTTAACGACCCAACCTCGGCGATCAACCTCCAGTTGAATGAACTGATTGAGC
ATATTGCGACCTTCGCACTTAATTACAAAATTAAGTATAATGAAGACAATAAGCTCATTGAGCAGATCGACGAATATCTG
GATGACACCTTTATGTTGTTCAGTAGTTATGGTATTAATATGCAGGATCTTCAGAAATGGCGGAAGTCAGGTAATCGACT
ATTCCGTTGTTTTGTCAATGCGACGAAAGAGAATCCTGCGAGTTTATCTTGTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829C4H9

Antitoxin

Source ID Structure
AlphaFold DB A0A829C483

References