Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | parDE/ParE-RHH |
| Location | 2204574..2205118 | Replicon | chromosome |
| Accession | NZ_CP045962 | ||
| Organism | Mycobacterium tuberculosis strain AUSMDU00018547 | ||
Toxin (Protein)
| Gene name | parE | Uniprot ID | G0TLU9 |
| Locus tag | GJE03_RS10230 | Protein ID | WP_003409896.1 |
| Coordinates | 2204574..2204870 (-) | Length | 99 a.a. |
Antitoxin (Protein)
| Gene name | parD | Uniprot ID | P67299 |
| Locus tag | GJE03_RS10235 | Protein ID | WP_003409899.1 |
| Coordinates | 2204867..2205118 (-) | Length | 84 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| GJE03_RS10175 | 2199607..2199957 | - | 351 | WP_003409871.1 | hypothetical protein | - |
| GJE03_RS10180 | 2199968..2200870 | - | 903 | WP_003409874.1 | hypothetical protein | - |
| GJE03_RS10185 | 2200891..2201082 | - | 192 | WP_003409876.1 | hypothetical protein | - |
| GJE03_RS10190 | 2201083..2201379 | - | 297 | WP_003409877.1 | hypothetical protein | - |
| GJE03_RS10195 | 2201619..2201834 | + | 216 | WP_003409878.1 | antitoxin | - |
| GJE03_RS10200 | 2201831..2202142 | + | 312 | WP_003409881.1 | type II toxin-antitoxin system VapC family toxin | - |
| GJE03_RS20800 | 2202116..2202637 | - | 522 | WP_003904745.1 | hypothetical protein | - |
| GJE03_RS10210 | 2202612..2202989 | + | 378 | WP_010886136.1 | type II toxin-antitoxin system toxin HigB | - |
| GJE03_RS10215 | 2203031..2203480 | + | 450 | WP_003409886.1 | type II toxin-antitoxin system antitoxin HigA | - |
| GJE03_RS10220 | 2203477..2204022 | + | 546 | WP_003409891.1 | SecB-like chaperone | - |
| GJE03_RS10225 | 2203911..2204525 | - | 615 | WP_003901296.1 | hypothetical protein | - |
| GJE03_RS10230 | 2204574..2204870 | - | 297 | WP_003409896.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
| GJE03_RS10235 | 2204867..2205118 | - | 252 | WP_003409899.1 | type II toxin-antitoxin system ParD family antitoxin | Antitoxin |
| GJE03_RS10240 | 2205105..2205599 | + | 495 | WP_003899099.1 | hypothetical protein | - |
| GJE03_RS10245 | 2205759..2206166 | - | 408 | WP_003409913.1 | type II toxin-antitoxin system VapC family toxin | - |
| GJE03_RS10250 | 2206170..2206442 | - | 273 | WP_003899100.1 | type II toxin-antitoxin system Phd/YefM family antitoxin | - |
| GJE03_RS10255 | 2206475..2207695 | - | 1221 | WP_003409919.1 | TetR family transcriptional regulator Mce3R | - |
| GJE03_RS10260 | 2208594..2209391 | + | 798 | WP_003899101.1 | ABC transporter permease | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 99 a.a. Molecular weight: 11268.64 Da Isoelectric Point: 6.8604
>T143136 WP_003409896.1 NZ_CP045962:c2204870-2204574 [Mycobacterium tuberculosis]
VSSRYLLSPAAQAHLEEIWDCTYDRWGVDQAEQYLRELQHAIDRAAANPRIGRACDEIRPGYRKLSAGSHTLFYRVTGEG
TIDVVRVLHQRMDVDRNL
VSSRYLLSPAAQAHLEEIWDCTYDRWGVDQAEQYLRELQHAIDRAAANPRIGRACDEIRPGYRKLSAGSHTLFYRVTGEG
TIDVVRVLHQRMDVDRNL
Download Length: 297 bp
>T143136 NZ_CP060950:c3013326-3013048 [Escherichia coli]
ATGATTCAAAGGGATATTGAATACTCGGGACAATTTTCAAAGGATGTAAAACTTGCACAAAAGCGTCATAAGGATATGAA
TAAATTGAAATATCTTATGACGCTTCTTATCAATAATGCTTTACCGCTTCCAGCTGTTTATAAAGACCACCCGCTGCAAG
GTTCATGGAAAGGTTATCGCGATGCTCATGTCGAACCGGACTGGATCCTGATTTACAAACTTACCGATAAACTTTTACGA
TTTGAGAGAACTGGAACTCACGCGGCGCTCTTTGGGTAA
ATGATTCAAAGGGATATTGAATACTCGGGACAATTTTCAAAGGATGTAAAACTTGCACAAAAGCGTCATAAGGATATGAA
TAAATTGAAATATCTTATGACGCTTCTTATCAATAATGCTTTACCGCTTCCAGCTGTTTATAAAGACCACCCGCTGCAAG
GTTCATGGAAAGGTTATCGCGATGCTCATGTCGAACCGGACTGGATCCTGATTTACAAACTTACCGATAAACTTTTACGA
TTTGAGAGAACTGGAACTCACGCGGCGCTCTTTGGGTAA
Antitoxin
Download Length: 84 a.a. Molecular weight: 9207.17 Da Isoelectric Point: 7.0150
>AT143136 WP_003409899.1 NZ_CP045962:c2205118-2204867 [Mycobacterium tuberculosis]
VGKNTSFVLDEHYSAFIDGEIAAGRYRSASEVIRSALRLLEDRETQLRALREALEAGERSGSSTPFDFDGFLGRKRADAS
RGR
VGKNTSFVLDEHYSAFIDGEIAAGRYRSASEVIRSALRLLEDRETQLRALREALEAGERSGSSTPFDFDGFLGRKRADAS
RGR
Download Length: 252 bp
>AT143136 NZ_CP060950:c3013589-3013329 [Escherichia coli]
ATGGCTGCTAACGCATTTGTTCGCGCCCGAATCGATGAAGATCTGAAGAATCAGGCGGCGGACGTACTGGCCGGGATGGG
GCTGACCATCTCTGACCTGGTTCGCATAACCCTCACAAAGGTCGCGCGTGAAAAGGCATTGCCGTTTGATTTACGCGAGC
CTAATCAATTAACCATTCAATCAATCAAAAACAGCGAAGCTGGCGTTGATGTTCATAAGGCCAAAGACGCCGATGATTTA
TTTGATAAATTAGGAATTTAA
ATGGCTGCTAACGCATTTGTTCGCGCCCGAATCGATGAAGATCTGAAGAATCAGGCGGCGGACGTACTGGCCGGGATGGG
GCTGACCATCTCTGACCTGGTTCGCATAACCCTCACAAAGGTCGCGCGTGAAAAGGCATTGCCGTTTGATTTACGCGAGC
CTAATCAATTAACCATTCAATCAATCAAAAACAGCGAAGCTGGCGTTGATGTTCATAAGGCCAAAGACGCCGATGATTTA
TTTGATAAATTAGGAATTTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | G0TLU9 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A7U4BUZ2 |