143130

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 1689643..1690259 Replicon chromosome
Accession NZ_CP045962
Organism Mycobacterium tuberculosis strain AUSMDU00018547

Toxin (Protein)


Gene name mazF Uniprot ID G0TJ74
Locus tag GJE03_RS07920 Protein ID WP_003407593.1
Coordinates 1689942..1690259 (+) Length 106 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID G0TJ73
Locus tag GJE03_RS07915 Protein ID WP_003900349.1
Coordinates 1689643..1689945 (+) Length 101 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GJE03_RS07905 1685529..1687376 + 1848 WP_154079934.1 methylmalonyl-CoA mutase small subunit -
GJE03_RS07910 1687377..1689629 + 2253 WP_003407587.1 methylmalonyl-CoA mutase -
GJE03_RS07915 1689643..1689945 + 303 WP_003900349.1 type II toxin-antitoxin system antitoxin MazE4 Antitoxin
GJE03_RS07920 1689942..1690259 + 318 WP_003407593.1 type II toxin-antitoxin system toxin endoribonuclease MazF4 Toxin
GJE03_RS07925 1690256..1691260 + 1005 WP_003407596.1 methylmalonyl Co-A mutase-associated GTPase MeaB -
GJE03_RS07930 1691313..1692602 + 1290 WP_003407599.1 serine hydrolase -
GJE03_RS07935 1692675..1693448 - 774 WP_003912632.1 class I SAM-dependent methyltransferase -
GJE03_RS07940 1693506..1693718 - 213 WP_003898900.1 dodecin family protein -
GJE03_RS20755 1693728..1693952 - 225 WP_160522526.1 NUDIX domain-containing protein -
GJE03_RS07950 1694222..1695250 + 1029 WP_003903478.1 glycosyltransferase family 2 protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(6-99)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 106 a.a.        Molecular weight: 11377.97 Da        Isoelectric Point: 7.9950

>T143130 WP_003407593.1 NZ_CP045962:1689942-1690259 [Mycobacterium tuberculosis]
VNAPLRGQVYRCDLGYGAKPWLIVSNNARNRHTADVVAVRLTTTRRTIPTWVAMGPSDPLTGYVNADNIETLGKDELGDY
LGEVTPATMNKINTALATALGLPWP

Download         Length: 318 bp

>T143130 NZ_CP060950:c1754957-1754850 [Escherichia coli]
ATGACGCTCGCAGAACTGGGCATGGCCTTCTGGCATGATTTAGCGGCTCCGGTCATTGCTGGCATTCTTGCCAGTATGAT
CGTGAACTGGCTGAATAAGCGGAAATAA

Antitoxin


Download         Length: 101 a.a.        Molecular weight: 11173.42 Da        Isoelectric Point: 9.5564

>AT143130 WP_003900349.1 NZ_CP045962:1689643-1689945 [Mycobacterium tuberculosis]
VPFLVALSGIISGVRDHSMTVRLDQQTRQRLQDIVKGGYRSANAAIVDAINKRWEALHDEQLDAAYAAAIHDNPAYPYES
EAERSAARARRNARQQRSAQ

Download         Length: 303 bp

>AT143130 NZ_CP060950:1755014-1755069 [Escherichia coli]
TCAAGAATGGCCCCCGTGATGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 5XE3
PDB 5XE2

Antitoxin

Source ID Structure
AlphaFold DB G0TJ73

References