143129

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/LOTUS_5_Limkain_b1(toxin)
Location 1577044..1577699 Replicon chromosome
Accession NZ_CP045962
Organism Mycobacterium tuberculosis strain AUSMDU00018547

Toxin (Protein)


Gene name vapC Uniprot ID A0A7U4FAR1
Locus tag GJE03_RS07405 Protein ID WP_003407268.1
Coordinates 1577044..1577445 (-) Length 134 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID G0TIK2
Locus tag GJE03_RS07410 Protein ID WP_003407272.1
Coordinates 1577442..1577699 (-) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GJE03_RS07390 1572516..1573901 - 1386 WP_003407260.1 cytochrome P450 -
GJE03_RS07395 1573979..1575013 + 1035 WP_003407264.1 AraC family transcriptional regulator -
GJE03_RS07400 1575059..1576789 - 1731 WP_031653809.1 PE family protein -
GJE03_RS07405 1577044..1577445 - 402 WP_003407268.1 type II toxin-antitoxin system VapC family toxin Toxin
GJE03_RS07410 1577442..1577699 - 258 WP_003407272.1 ribbon-helix-helix domain-containing protein Antitoxin
GJE03_RS07415 1577782..1578741 - 960 WP_003908687.1 alpha/beta hydrolase -
GJE03_RS07420 1578766..1579728 - 963 WP_003407279.1 alpha/beta hydrolase -
GJE03_RS07425 1579727..1580464 + 738 WP_031647000.1 lysoplasmalogenase -
GJE03_RS07430 1580545..1582512 + 1968 WP_003407285.1 primosomal protein N' -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-108)

Antitoxin

Ribbon-helix-helix protein, CopG

(3-39)


Sequences

Toxin        


Download         Length: 134 a.a.        Molecular weight: 14894.39 Da        Isoelectric Point: 11.6897

>T143129 WP_003407268.1 NZ_CP045962:c1577445-1577044 [Mycobacterium tuberculosis]
MILVDSDVLIAHLRGVVAARDWLVSARKDGPLAISVVSTAELIGGMRTAERREVWRLLASFRVQPATEVIARRAGDMMRR
YRRSHNRIGLGDYLIAATADVQGLQLATLNVWHFPMFEQLKPPFAVPGHRPRA

Download         Length: 402 bp

>T143129 NZ_CP060950:c1754474-1754367 [Escherichia coli]
ATGACGCTCGCAGAGCTGGGCATGGCCTTCTGGCATGATTTAGCGGCTCCGGTCATTGCTGGCATTCTTGCCAGTATGAT
CGTGAACTGGCTGAACAAACGGAAGTAA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9443.58 Da        Isoelectric Point: 6.4631

>AT143129 WP_003407272.1 NZ_CP045962:c1577699-1577442 [Mycobacterium tuberculosis]
MKRTNIYLDEEQTASLDKLAAQEGVSRAELIRLLLNRALTTAGDDLASDLQAINDSFGTLRHLDPPVRRSGGREQHLAQV
WRATS

Download         Length: 258 bp

>AT143129 NZ_CP060950:1754522-1754588 [Escherichia coli]
GGTCTAGATGCAAGATTAGCCCCCGTGGTGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U4FAR1

Antitoxin

Source ID Structure
AlphaFold DB G0TIK2

References