Detailed information of TA system TA143126

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/PIN(toxin)
• Location: 1383999..1384687
• Replicon: chromosome
• Accession: NZ_CP045962
• Organism: Mycobacterium tuberculosis strain AUSMDU00018547

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: G0THR7
• Locus tag: GJE03_RS06570
• Protein ID: WP_003406304.1
• Coordinates: 1384256..1384687 (+)
• Length: 144 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: G0THR6
• Locus tag: GJE03_RS06565
• Protein ID: WP_003406302.1
• Coordinates: 1383999..1384259 (+)
• Length: 87 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
GJE03_RS06545	1379576..1380400	+	825	WP_003900298.1	trehalose ABC transporter permease SugB	-
GJE03_RS06550	1380405..1381586	+	1182	WP_003406299.1	trehalose ABC transporter ATP-binding protein SugC	-
GJE03_RS06555	1381663..1382763	-	1101	WP_003406300.1	magnesium/cobalt transporter CorA	-
GJE03_RS06560	1382934..1383923	+	990	WP_003406301.1	malate dehydrogenase	-
GJE03_RS06565	1383999..1384259	+	261	WP_003406302.1	type II toxin-antitoxin system antitoxin VapB33	Antitoxin
GJE03_RS06570	1384256..1384687	+	432	WP_003406304.1	type II toxin-antitoxin system VapC family toxin	Toxin
GJE03_RS06575	1384710..1386398	-	1689	WP_154079918.1	PE family protein	-
GJE03_RS06580	1386578..1387438	+	861	WP_003903377.1	hypothetical protein	-
GJE03_RS06585	1387519..1388349	-	831	WP_003898788.1	SDR family NAD(P)-dependent oxidoreductase	-
GJE03_RS06590	1388406..1388699	-	294	WP_003898789.1	type II toxin-antitoxin system mRNA interferase RelE	-
GJE03_RS06595	1388696..1388965	-	270	WP_003406322.1	type II toxin-antitoxin system Phd/YefM family antitoxin	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain toxin (2-142)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 144 a.a.
• Molecular weight: 15873.08 Da
• Isoelectric Point: 5.8838

>T143126 WP_003406304.1 NZ_CP045962:1384256-1384687 [Mycobacterium tuberculosis]
VIIPDINLLLYAVITGFPQHRRAHAWWQDTVNGHTRIGLTYPALFGFLRIATSARVLAAPLPTADAIAYVREWLSQPNVD
LLTAGPRHLDIALGLLDKLGTASHLTTDVQLAAYGIEYDAEIHSSDTDFARFADLKWTDPLRE

Nucleotide

• Length: 432 bp

>T143126 NZ_CP060950:c1086029-1085622 [Escherichia coli]
GTGGTCCTGTGGCAATCTGATTTGCGCGTCTCCTGGCGCGCACAGTGGCTTTCCTTGCTGATTCATGGGCTGGTTGCCGC
TGTTATTTTACTCATGCCCTGGCCACTCAGTTACACCCCGTTATGGATGGTGTTACTTTCGCTGGTGGTGTTTGATTGCG
TTCGCAGCCAGCGGCGTATTAATGCTCGCCAGGGGGAAATTCGCTTGTTGATGGACGGGCGTTTGCGTTGGCAAGGGCAG
GAGTGGTGCATCGTCAAAGCACCGTGGATGATTAAGAGCGGCATGATGCTGCGTTTACGTTCTGATGGCGGTAAACGGCA
ACATTTATGGCTGGCAGCCGACAGCATGGACGAAGCCGAATGGCGGGATTTACGGCGGATTTTGTTGCAACAAGAGACGC
AAAGATAA

Antitoxin

Protein

• Length: 87 a.a.
• Molecular weight: 9918.25 Da
• Isoelectric Point: 6.4755

>AT143126 WP_003406302.1 NZ_CP045962:1383999-1384259 [Mycobacterium tuberculosis]
MRTTLTLDDDVVRLVEDAVHRERRPMKQVINDALRRALAPPVKRQEQYRLEPHESAVRSGLDLAGFNKLADELEDEALLD
ATRRAR

Nucleotide

• Length: 261 bp

>AT143126 NZ_CP060950:c1086276-1086010 [Escherichia coli]
ATGGACATTAACAACAAAGCCCGCATTCATTGGGCATGCCGCCGTGGTATGCGCGAACTCGATATTTCAATCATGCCGTT
TTTCGAACATGAGTACGACAGCTTAAGCGATGACGAAAAACGCATCTTTATTCGTCTGCTGGAATGTGACGATCCGGACC
TGTTTAACTGGCTGATGAATCACGGTAAACCGGCCGATGCAGAACTGGAAATGATGGTCCGACTCATCCAGACACGGAAC
CGGGAACGTGGTCCTGTGGCAATCTGA

Structures

Toxin

• AlphaFold DB: G0THR7

Antitoxin

• AlphaFold DB: G0THR6