143121

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) unclassified/Polyketide_cyc2(toxin)
Location 1016085..1016704 Replicon chromosome
Accession NZ_CP045962
Organism Mycobacterium tuberculosis strain AUSMDU00018547

Toxin (Protein)


Gene name novel[antitoxin] Uniprot ID -
Locus tag GJE03_RS04820 Protein ID WP_003404726.1
Coordinates 1016270..1016704 (+) Length 145 a.a.

Antitoxin (Protein)


Gene name novel[toxin] Uniprot ID G0TFQ5
Locus tag GJE03_RS04815 Protein ID WP_003404724.1
Coordinates 1016085..1016264 (+) Length 60 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GJE03_RS04805 1011558..1013138 + 1581 WP_003909313.1 serine hydrolase -
GJE03_RS04810 1013135..1015528 + 2394 WP_003898639.1 cation-translocating P-type ATPase -
GJE03_RS20685 1015801..1015959 + 159 WP_003404720.1 hypothetical protein -
GJE03_RS04815 1016085..1016264 + 180 WP_003404724.1 antitoxin Antitoxin
GJE03_RS04820 1016270..1016704 + 435 WP_003404726.1 SRPBCC family protein Toxin
GJE03_RS04825 1016802..1017575 + 774 WP_154079905.1 VOC family protein -
GJE03_RS04830 1017640..1018089 + 450 WP_003404738.1 hypothetical protein -
GJE03_RS04835 1018224..1018454 - 231 WP_003898642.1 hypothetical protein -
GJE03_RS04840 1018621..1020129 - 1509 WP_154079906.1 carotenoid oxygenase family protein -
GJE03_RS04845 1020131..1021369 - 1239 WP_003404744.1 acetyl-CoA acetyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Polyketide cyclase/dehydrase

(1-142)

Antitoxin

Antitoxin Rv0909/MT0933

(4-50)


Sequences

Toxin        


Download         Length: 145 a.a.        Molecular weight: 15754.47 Da        Isoelectric Point: 9.7977

>T143121 WP_003404726.1 NZ_CP045962:1016270-1016704 [Mycobacterium tuberculosis]
MAKLSGSIDVPLPPEEAWMHASDLTRYREWLTIHKVWRSKLPEVLEKGTVVESYVEVKGMPNRIKWTIVRYKPPEGMTLN
GDGVGGVKVKLIAKVAPKEHGSVVSFDVHLGGPALLGPIGMIVAAALRADIRESLQNFVTVFAG

Download         Length: 435 bp

>T143121 NZ_CP060948:85248-85397 [Escherichia coli O157:H7 str. EC10]
ATGACGAAATATGCCCTTATCGGGTTGCTCGCCGTGTGTGCCACGGTATTGTGTTTTTCACTGATATTCAGGGAACGGTT
ATGTGAACTGAATATTCACAGGGGAAATACAGTGGTGCAGGTAACTCTGGCCTACGAAGCACGGAAGTAA

Antitoxin


Download         Length: 60 a.a.        Molecular weight: 6394.06 Da        Isoelectric Point: 4.3059

>AT143121 WP_003404724.1 NZ_CP045962:1016085-1016264 [Mycobacterium tuberculosis]
MGILDKVKNLLSQNADKVETVINKAGEFVDEQTQGNYSDAIHKLQDAASNVVGMSDQQS

Download         Length: 180 bp

>AT143121 NZ_CP060948:c85203-85144 [Escherichia coli O157:H7 str. EC10]
TAAGTACTTCATGCAGACCTCACGAGTTAATGGATTAACGAGTGGGGTCTTCGCATTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB G0TFQ5

References