143119

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 759648..760336 Replicon chromosome
Accession NZ_CP045962
Organism Mycobacterium tuberculosis strain AUSMDU00018547

Toxin (Protein)


Gene name vapC Uniprot ID P9WFB2
Locus tag GJE03_RS03490 Protein ID WP_003403386.1
Coordinates 759648..760085 (-) Length 146 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID O06777
Locus tag GJE03_RS03495 Protein ID WP_003911263.1
Coordinates 760082..760336 (-) Length 85 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GJE03_RS03460 755899..756909 + 1011 WP_031653722.1 ABC transporter ATP-binding protein -
GJE03_RS03465 757297..757680 - 384 WP_003403365.1 ribonuclease VapC6 -
GJE03_RS03470 757775..757930 - 156 WP_003403368.1 type II toxin-antitoxin system VapB family antitoxin -
GJE03_RS03475 758006..758722 - 717 WP_003903122.1 CPBP family intramembrane metalloprotease -
GJE03_RS03480 758998..759306 - 309 WP_003403376.1 type II toxin-antitoxin system PemK/MazF family toxin -
GJE03_RS03485 759293..759538 - 246 WP_003403381.1 ribbon-helix-helix protein, CopG family -
GJE03_RS03490 759648..760085 - 438 WP_003403386.1 type II toxin-antitoxin system VapC family toxin Toxin
GJE03_RS03495 760082..760336 - 255 WP_003911263.1 antitoxin VapB7 Antitoxin
GJE03_RS03500 760450..762813 + 2364 WP_003403397.1 arylsulfatase AtsD -
GJE03_RS03505 762876..763202 + 327 WP_003403401.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
GJE03_RS03510 763114..763452 + 339 WP_154079891.1 PIN domain-containing protein -
GJE03_RS03515 763449..763622 + 174 WP_003898549.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-126)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 146 a.a.        Molecular weight: 15245.39 Da        Isoelectric Point: 5.1865

>T143119 WP_003403386.1 NZ_CP045962:c760085-759648 [Mycobacterium tuberculosis]
MIVLDTTVLVYAKGAEHPLRDPCRDLVAAIADERIAATTTAEVIQEFVHVRARRRDRSDAAALGRVTMPNCSRRYSPSIE
ATSKRGLTLFETTPGLEACDAVLAAVAASAGATALVSADPAFADLSDVVHVIPDAAGMVSLLGDR

Download         Length: 438 bp

>T143119 NZ_CP060948:14747-15163 [Escherichia coli O157:H7 str. EC10]
GTGAACAAGATCTATATGCTCGACACGAACATCTGCTCGTTCATCATGCGCGAGCAGCCTGAAGCAGTGCTTAAGAATCT
GGAGCAGGCGGTGCTGCGCGGTCACCGTATCGTGGTCTCGGCCATCACCTACTCCGAGATGCGCTTCGGCGCCACCGGTC
CAAAGGCATCGCCACGCCACGTGCAGCTGGTTGACGCGTTCTGCGCCCGTCTCGATGCCATCCTGCCCTGGGATCGCGCT
GCGGTGGATGCAACCACGGAGGTTAAGGTGGCGCTGCGCCTCGCCGGCACGCCGATCGGTCCAAACGACACGGCGATCGC
CGGGCACGCCATCGCCACCGGGGCAATACTGGTGACGAATAATGTGAGAGAGTTTGAGCGGGTGCCTGGACTGGTACTGG
AAGACTGGGCAGGATAA

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 9450.99 Da        Isoelectric Point: 11.7073

>AT143119 WP_003911263.1 NZ_CP045962:c760336-760082 [Mycobacterium tuberculosis]
MSMRLAHRLQILLDDECHRRITAVARERGVPVATVVREAIDRGLVSPAGRRKSAGRRLLDAADMSVPEPRELKQELEALR
ARRG

Download         Length: 255 bp

>AT143119 NZ_CP060948:14520-14750 [Escherichia coli O157:H7 str. EC10]
ATGAGAACCGTATCTATTTTCAAAAATGGCAATAACCGCGCGATCCGTCTGCCCCGCGATCTGGATTTTGAGGGGGTGAG
TGAGCTGGAGATTGTACGGGAAGGGGACAGAATCATTCTGCGTCCCCTCCGCCCGAGCTGGAGCTCATTCCTGGAGCTAG
AAAAGGCCGATCCGGGCTTTATGACGGAACGCGAGGACGTTGTCTGCGACGAAGGACGATTTAACCTGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U4BSW5

Antitoxin

Source ID Structure
AlphaFold DB A0A806JQG1

References