143117

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 758998..759538 Replicon chromosome
Accession NZ_CP045962
Organism Mycobacterium tuberculosis strain AUSMDU00018547

Toxin (Protein)


Gene name mazF Uniprot ID P9WII0
Locus tag GJE03_RS03480 Protein ID WP_003403376.1
Coordinates 758998..759306 (-) Length 103 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID G0TQE0
Locus tag GJE03_RS03485 Protein ID WP_003403381.1
Coordinates 759293..759538 (-) Length 82 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GJE03_RS03455 754313..755818 + 1506 WP_003403360.1 carotenoid cleavage oxygenase -
GJE03_RS03460 755899..756909 + 1011 WP_031653722.1 ABC transporter ATP-binding protein -
GJE03_RS03465 757297..757680 - 384 WP_003403365.1 ribonuclease VapC6 -
GJE03_RS03470 757775..757930 - 156 WP_003403368.1 type II toxin-antitoxin system VapB family antitoxin -
GJE03_RS03475 758006..758722 - 717 WP_003903122.1 CPBP family intramembrane metalloprotease -
GJE03_RS03480 758998..759306 - 309 WP_003403376.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
GJE03_RS03485 759293..759538 - 246 WP_003403381.1 ribbon-helix-helix protein, CopG family Antitoxin
GJE03_RS03490 759648..760085 - 438 WP_003403386.1 type II toxin-antitoxin system VapC family toxin -
GJE03_RS03495 760082..760336 - 255 WP_003911263.1 antitoxin VapB7 -
GJE03_RS03500 760450..762813 + 2364 WP_003403397.1 arylsulfatase AtsD -
GJE03_RS03505 762876..763202 + 327 WP_003403401.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
GJE03_RS03510 763114..763452 + 339 WP_154079891.1 PIN domain-containing protein -
GJE03_RS03515 763449..763622 + 174 WP_003898549.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(1-101)

Antitoxin

Ribbon-helix-helix protein, CopG

(2-38)


Sequences

Toxin        


Download         Length: 103 a.a.        Molecular weight: 11320.10 Da        Isoelectric Point: 11.6554

>T143117 WP_003403376.1 NZ_CP045962:c759306-758998 [Mycobacterium tuberculosis]
MRRGELWFAATPGGDRPVLVLTRDPVADRIGAVVVVALTRTRRGLVSELELTAVENRVPSDCVVNFDNIHTLPRTAFRRR
ITRLSPARLHEACQTLRASTGC

Download         Length: 309 bp

>T143117 NZ_CP060947:2269-2544 [Escherichia coli O157:H7 str. EC10]
ATGGAACTGAAGTGGACCAGTAAGGCGCTTTCTGATTTGGCGCGGTTATATGATTTTCTGGTGCTGGCCAGTAAACCTGC
GGCCGCCAGAACGGTGCAGTCCCTGACACAGGCTCCGGTCATTCTGTTAACTCATCCACGTATGGGGGAACAGTTATTTC
AGTTTGAACCCAGGGAGGTCAGACGGATTTTTGCTGGCGAGTACGAAATCCGTTACGAACTTACTGGCCAGACTATTTAT
GTATTGCGCCTGTGGCACACACGAGAAAACAGGTAG

Antitoxin


Download         Length: 82 a.a.        Molecular weight: 9169.01 Da        Isoelectric Point: 4.2070

>AT143117 WP_003403381.1 NZ_CP045962:c759538-759293 [Mycobacterium tuberculosis]
MLSFRADDHDVDLADAWARRLHIGRSELLRDALRRHLAALAADQDVQAYTERPLTDDENALAEIADWGPAEDWADWADAA
R

Download         Length: 246 bp

>AT143117 NZ_CP060947:1985-2269 [Escherichia coli O157:H7 str. EC10]
ATGCAAATGAAAAACAATACCGCACAGGCAACAAAAGTAATTACCGCGCATGTGCCATTACCTATGGCTGATAAAGTCGA
CCAGATGGCCGCCAGACTGGAACGCTCCCGGGGCTGGATTATCAAACAGGCGCTTTCTGCATGGCTTGCCCAGGAGGAGG
AGCGTAATCGCCTGACGCTGGAAGCCCTGGACGATGTGACATCCGGACAGGTTATCGACCATCAGGCTGTACAGGCCTGG
GCGGACAGCCTCAGTACTGACAATCCGTTACCGGTGCCACGCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U4BSE5

Antitoxin

Source ID Structure
AlphaFold DB G0TQE0

References