143116

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VapB
Location 757297..757930 Replicon chromosome
Accession NZ_CP045962
Organism Mycobacterium tuberculosis strain AUSMDU00018547

Toxin (Protein)


Gene name vapC Uniprot ID G0TQD6
Locus tag GJE03_RS03465 Protein ID WP_003403365.1
Coordinates 757297..757680 (-) Length 128 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID P9WJ56
Locus tag GJE03_RS03470 Protein ID WP_003403368.1
Coordinates 757775..757930 (-) Length 52 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GJE03_RS03440 752589..753125 + 537 WP_003403341.1 50S ribosomal protein L10 -
GJE03_RS03445 753162..753554 + 393 WP_003403353.1 50S ribosomal protein L7/L12 -
GJE03_RS03450 753547..754242 - 696 WP_003403355.1 TetR/AcrR family transcriptional regulator -
GJE03_RS03455 754313..755818 + 1506 WP_003403360.1 carotenoid cleavage oxygenase -
GJE03_RS03460 755899..756909 + 1011 WP_031653722.1 ABC transporter ATP-binding protein -
GJE03_RS03465 757297..757680 - 384 WP_003403365.1 ribonuclease VapC6 Toxin
GJE03_RS03470 757775..757930 - 156 WP_003403368.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
GJE03_RS03475 758006..758722 - 717 WP_003903122.1 CPBP family intramembrane metalloprotease -
GJE03_RS03480 758998..759306 - 309 WP_003403376.1 type II toxin-antitoxin system PemK/MazF family toxin -
GJE03_RS03485 759293..759538 - 246 WP_003403381.1 ribbon-helix-helix protein, CopG family -
GJE03_RS03490 759648..760085 - 438 WP_003403386.1 type II toxin-antitoxin system VapC family toxin -
GJE03_RS03495 760082..760336 - 255 WP_003911263.1 antitoxin VapB7 -
GJE03_RS03500 760450..762813 + 2364 WP_003403397.1 arylsulfatase AtsD -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Bacterial antitoxin of type II TA system, VapB

(3-44)


Sequences

Toxin        


Download         Length: 128 a.a.        Molecular weight: 13959.73 Da        Isoelectric Point: 6.0803

>T143116 WP_003403365.1 NZ_CP045962:c757680-757297 [Mycobacterium tuberculosis]
MAAATTTGTHRGLELRAAQRAVGSCEPQRAEFCRSARNADEFDQMSRMFGDVYPDVPVPKSVWRWIDSAQHRLARAGAVG
ALSVVDLLICDTAAARGLVVLHDDADYELAERHLPDIRVRRVVSADD

Download         Length: 384 bp

>T143116 NZ_CP060946:4353071-4353373 [Escherichia coli O157:H7 str. EC10]
ATGGCTCAAAAGAATAATATAAGGAGTTTTCGTGATGCCTGGCTGGCTGATTTTTTTGTCCATTCAACGCCACATCGAAA
GATCCCTGCTGAAATCCATACCTCGTTATCACGAAAGTTGGACATCATTAATGCTGCCACTTCTCATCGGGATTTACGCT
CCCCTCCGGGGAACCGATACGAAGAGTTGTCCGGGAAATTACAGGAATATTCCTCCATTAGAGTGAATAAACAGTACCGA
CTGATATTTAAATGGGTTAATGGCAAGGCCGAAGAATTGTTTTTAGACCCACACAACTACTAA

Antitoxin


Download         Length: 52 a.a.        Molecular weight: 5872.72 Da        Isoelectric Point: 5.7734

>AT143116 WP_003403368.1 NZ_CP045962:c757930-757775 [Mycobacterium tuberculosis]
VSVTQIDLDDEALADVMRIAAVHTKKEAVNLAMRDYVERFRRIEALARSRE

Download         Length: 156 bp

>AT143116 NZ_CP060946:4353409-4353750 [Escherichia coli O157:H7 str. EC10]
ATGAAACAGGCAACAAGAAAACCGACGACACCCGGAGATATTCTTCTCTATGAATATCTGGAACCGCTCGATTTGAAAAT
CAATGAGTTAGCAGAGTTGCTGCATGTTCATCGTAATAGCGTCAGTGCACTGATCAATAACAATCGTAAACTCACCACTG
AGATGGCATTCCGTCTGGCGAAAGTTTTTGATACCACAGTCGATTTTTGGCTAAACCTCCAGGCGGCAGTTGATCTTTGG
GAAGTTGAAAACAACATGCGTACCCAGGAAGAATTGGGACGGATTGAAACAGTGGCTGAATATTTGGCACGCCGTGAAGA
GCGTGCAAAAAAGGTCGCGTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G0TQD6

Antitoxin

Source ID Structure
AlphaFold DB A0A7U4BSF8

References