Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 714561..715186 Replicon chromosome
Accession NZ_CP045962
Organism Mycobacterium tuberculosis strain AUSMDU00018547

Toxin (Protein)


Gene name vapC Uniprot ID G0TQA0
Locus tag GJE03_RS03250 Protein ID WP_003403218.1
Coordinates 714785..715186 (+) Length 134 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID P9WJ36
Locus tag GJE03_RS03245 Protein ID WP_003403213.1
Coordinates 714561..714788 (+) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GJE03_RS03215 709740..709961 - 222 WP_003898525.1 DUF4926 domain-containing protein -
GJE03_RS03220 710103..710708 + 606 WP_003898526.1 hypothetical protein -
GJE03_RS03225 710727..713294 - 2568 WP_154079890.1 SEC-C domain-containing protein -
GJE03_RS03230 713378..714127 + 750 WP_003898528.1 hypothetical protein -
GJE03_RS03235 714124..714366 + 243 WP_003403210.1 hypothetical protein -
GJE03_RS03245 714561..714788 + 228 WP_003403213.1 antitoxin VapB29 Antitoxin
GJE03_RS03250 714785..715186 + 402 WP_003403218.1 type II toxin-antitoxin system ribonuclease VapC29 Toxin
GJE03_RS20665 715315..715398 + 84 Protein_640 galactose-1-phosphate uridylyltransferase -
GJE03_RS03255 715417..716499 + 1083 WP_031652152.1 galactose-1-phosphate uridylyltransferase -
GJE03_RS03260 716496..717587 + 1092 WP_003900977.1 galactokinase -
GJE03_RS03265 717982..719139 + 1158 WP_003903091.1 hypothetical protein -
GJE03_RS03270 719150..720097 + 948 WP_003403232.1 DUF732 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(3-120)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 134 a.a.        Molecular weight: 13937.76 Da        Isoelectric Point: 5.7441

>T143113 WP_003403218.1 NZ_CP045962:714785-715186 [Mycobacterium tuberculosis]
VTVLLDANVLIALVVAEHVHHDAAADWLMASDTGFATCPMTQGSLVRFLVRSGQSAAAARDVVSAVQCTSRHEFWPDALS
FAGVEVAGVVGHRQVTDAYLAQLARSHDGQLATLDSGLAHLHGDVAVLIPTTT

Download         Length: 402 bp

>T143113 NZ_CP060946:3729324-3729611 [Escherichia coli O157:H7 str. EC10]
ATGCCAATGGAGTTTGAATGGGATGCAAACAAGGCCAAAAGTAATCGGGTGAAACATGGCATCCGCTTTGAAGATGCGGT
GTTGGTGTTTGATGATCCACAACATTTGTCACAGCAAGATCGCATAGAAAACGGTGAGTATCGCTGGCAGACTATCGGCC
TGGTTTACGGCATCGTGGTTATCCTGGTTGCGCATACCATCCGTTTCGAAAGTGGAAATGAAATTATTCGAATCATCAGT
GCACGAAAAGCAGATCGTAAAGAGAGGAATCGCTATGAGCATGGTTAA

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8163.17 Da        Isoelectric Point: 5.6307

>AT143113 WP_003403213.1 NZ_CP045962:714561-714788 [Mycobacterium tuberculosis]
VRTTIDLPQDLHKQALAIARDTHRTLSETVADLMRRGLAANRPTALSSDPRTGLPLVSVGTVVTSEDVRSLEDEQ

Download         Length: 228 bp

>AT143113 NZ_CP060946:3729598-3729900 [Escherichia coli O157:H7 str. EC10]
ATGAGCATGGTTAAACATAAACGAGGGACCTCCTCTATACTCGATGTGCAGCATGAGGCCGAACTGAAGGCGCTGGCGAA
TAAATCCGACGAAGATATTGATTACAGCGATATCCCACCTTCCAGCGATGAGCAATGGTCTAACGCAGAACGCGGTAAGT
TTTATCGGCCATTGAAAACTCAGGCTTCGGTGCGTATTGATGCTGATGTGATGGAATGGTTGAAGCGACCAGGTAAGGGC
TATCAAACTCGCCTGAACGCAATTTTACGTGAAGCGATGCTGCGCGATCAGAACAAAAAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G0TQA0

Antitoxin

Source ID Structure
AlphaFold DB A0A7U4BSC9

References