143112

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC(toxin)
Location 707023..707666 Replicon chromosome
Accession NZ_CP045962
Organism Mycobacterium tuberculosis strain AUSMDU00018547

Toxin (Protein)


Gene name vapC Uniprot ID P67239
Locus tag GJE03_RS03190 Protein ID WP_003403187.1
Coordinates 707265..707666 (+) Length 134 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID G0TQ91
Locus tag GJE03_RS03185 Protein ID WP_003403184.1
Coordinates 707023..707268 (+) Length 82 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GJE03_RS03150 702303..702833 - 531 WP_003917320.1 two component system sensor kinase HK2 -
GJE03_RS03155 702817..703578 - 762 WP_003403148.1 two-component system response regulator TcrA -
GJE03_RS03160 703635..703946 + 312 WP_003403164.1 hypothetical protein -
GJE03_RS03165 704018..704968 + 951 WP_003907436.1 DUF1259 domain-containing protein -
GJE03_RS03170 705209..705793 + 585 WP_003403171.1 IS607-like element IS1536 family transposase -
GJE03_RS03175 705795..706505 + 711 Protein_626 transposase -
GJE03_RS03180 706508..706978 + 471 WP_003898523.1 hypothetical protein -
GJE03_RS03185 707023..707268 + 246 WP_003403184.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
GJE03_RS03190 707265..707666 + 402 WP_003403187.1 type II toxin-antitoxin system VapC family toxin Toxin
GJE03_RS03200 708054..708221 - 168 WP_077385191.1 DUF3800 domain-containing protein -
GJE03_RS03205 708254..708451 - 198 WP_003403191.1 hypothetical protein -
GJE03_RS03210 708774..709688 - 915 WP_003904440.1 hypothetical protein -
GJE03_RS03215 709740..709961 - 222 WP_003898525.1 DUF4926 domain-containing protein -
GJE03_RS03220 710103..710708 + 606 WP_003898526.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(1-124)

Antitoxin

Antitoxin VapB-like

(1-80)


Sequences

Toxin        


Download         Length: 134 a.a.        Molecular weight: 14501.21 Da        Isoelectric Point: 4.4463

>T143112 WP_003403187.1 NZ_CP045962:707265-707666 [Mycobacterium tuberculosis]
VIVDTSAIIAILRDEDDAAAYADALANADVRRLSAASYLECGIVLDSQRDPVISRALDELIEEAEFVVEPVTERQARLAR
AAYADFGRGSGHPAGLNFGDCLSYALAIDRREPLLWKGNDFGHTGVQRALDRR

Download         Length: 402 bp

>T143112 NZ_CP060946:3591793-3592143 [Escherichia coli O157:H7 str. EC10]
ATGGTAAAGAAAAGTGAATTTGAACGGGGAGACATTGTGCTGGTTGGCTTTGATCCAGCAAGCGGCCATGAACAGCAAGG
TGCTGGTCGACCTGCGCTTGTGCTCTCCGTTCAAGCCTTTAATCAACTGGGAATGACGCTGGTGGCCCCCATTACGCAGG
GCGGAAATTTTGCCCGTTATGCCGGATTTAGCGTTCCTTTACATTGCGAAGAAGGCGATGTGCACGGCGTGGTGCTGGTG
AATCAGGTGCGGATGATGGATCTACGCGCCCGGCTGGCAAAGCGTATTGGTCTGGCTGCGGATGAGGTGGTGGAAGAGGC
GTTATTACGCTTGCAGGCGGTGGTGGAATAA

Antitoxin


Download         Length: 82 a.a.        Molecular weight: 8813.12 Da        Isoelectric Point: 10.3486

>AT143112 WP_003403184.1 NZ_CP045962:707023-707268 [Mycobacterium tuberculosis]
MALNIKDPSVHQAVKQIAKITGESQARAVATAVNERLARLRSDDLAARLLAIGHKTASRMSPEAKRLDHDALLYDERGLP
A

Download         Length: 246 bp

>AT143112 NZ_CP060946:3591548-3591799 [Escherichia coli O157:H7 str. EC10]
ATGCGTATTACCATAAAAAGATGGGGGAACAGTGCAGGTATGGTCATTCCCAATATCGTAATGAAAGAACTTAACTTACA
GCCGGGGCAGAGCGTGGAAGCGCAGGTGAGCAACAACCAACTGATTCTGACACCCATCTCCAGGCGCTACTCGCTTGATG
AACTGCTGGCACAGTGTGACATGAACGCCGCGGAACTTAGCGAGCAGGATGTCTGGGGTAAATCCACCCCTGCGGGTGAC
GAAATATGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U4BSD6

Antitoxin

Source ID Structure
AlphaFold DB G0TQ91

References