Detailed information of TA system TA143097

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vagCD/VapC-VagC
• Location: 149438..150108
• Replicon: plasmid pAUSMDU00010532_01
• Accession: NZ_CP045959
• Organism: Salmonella enterica subsp. enterica serovar Birkenhead strain AUSMDU00010532

Toxin (Protein)

• Gene name: vagD
• Uniprot ID: -
• Locus tag: GJE06_RS23285
• Protein ID: WP_154074368.1
• Coordinates: 149438..149854 (-)
• Length: 139 a.a.

Antitoxin (Protein)

• Gene name: vagC
• Uniprot ID: -
• Locus tag: GJE06_RS23290
• Protein ID: WP_154074260.1
• Coordinates: 149878..150108 (-)
• Length: 77 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
GJE06_RS23260	144877..145740	-	864	WP_080102198.1	Dam family site-specific DNA-(adenine-N6)-methyltransferase	-
GJE06_RS23265	146142..147377	-	1236	WP_154074258.1	IS256 family transposase	-
GJE06_RS23270	147455..147736	-	282	WP_154074259.1	helix-turn-helix transcriptional regulator	-
GJE06_RS23275	147717..148046	-	330	WP_080861456.1	type II toxin-antitoxin system RelE/ParE family toxin	-
GJE06_RS23280	148230..148478	-	249	Protein_138	Rpn family recombination-promoting nuclease/putative transposase	-
GJE06_RS23285	149438..149854	-	417	WP_154074368.1	type II toxin-antitoxin system VapC family toxin	Toxin
GJE06_RS23290	149878..150108	-	231	WP_154074260.1	AbrB/MazE/SpoVT family DNA-binding domain-containing protein	Antitoxin
GJE06_RS23295	150416..150565	+	150	Protein_141	transposase	-
GJE06_RS23300	150706..151401	-	696	WP_154074261.1	ATP-binding cassette domain-containing protein	-
GJE06_RS23305	151368..151535	-	168	Protein_143	N-acetyltransferase	-
GJE06_RS23310	151584..151661	+	78	Protein_144	IS1 family transposase	-
GJE06_RS23315	151655..152226	-	572	Protein_145	recombinase family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Non-Mobilizable plasmid	-	-	1..329074	329074

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Type I toxin-antitoxin system, toxin Ldr (1-35)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 139 a.a.
• Molecular weight: 20475.56 Da
• Isoelectric Point: 5.5500

>T143097 WP_154074368.1 NZ_CP045959:c149854-149438 [Salmonella enterica subsp. enterica serovar Birkenhead]
FFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFF
FFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFF

Nucleotide

• Length: 417 bp

>T143097 NZ_CP060946:c322645-322538 [Escherichia coli O157:H7 str. EC10]
ATGACGCTCGCGCAGTTTGCCATGACTTTCTGGCACGACCTGGCAGCACCGATCCTGGCGGGGATTATTACCGCAGCGAT
TGTCAGCTGGTGGCGTAACCGGAAGTAA

Antitoxin

Protein

• Length: 77 a.a.
• Molecular weight: 11350.61 Da
• Isoelectric Point: 5.5500

>AT143097 WP_154074260.1 NZ_CP045959:c150108-149878 [Salmonella enterica subsp. enterica serovar Birkenhead]
FFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFF

Nucleotide

• Length: 231 bp

>AT143097 NZ_CP060946:322692-322758 [Escherichia coli O157:H7 str. EC10]
TGTCTGGTTTCAAGATTAGCCCCCGTTTTGTTGTCAGGTTTTACCTCTCAACGTGCGGGGGTTTTCT