Detailed information of TA system TA143094

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC-VagC
• Location: 24364..24989
• Replicon: plasmid pAUSMDU00010529_01
• Accession: NZ_CP045950
• Organism: Salmonella enterica subsp. enterica serovar Typhimurium strain AUSMDU00010529

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: GJE11_RS23690
• Protein ID: WP_000911322.1
• Coordinates: 24591..24989 (+)
• Length: 133 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: -
• Locus tag: GJE11_RS23685
• Protein ID: WP_000450265.1
• Coordinates: 24364..24591 (+)
• Length: 76 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
GJE11_RS23685	24364..24591	+	228	WP_000450265.1	toxin-antitoxin system antitoxin VapB	Antitoxin
GJE11_RS23690	24591..24989	+	399	WP_000911322.1	tRNA(fMet)-specific endonuclease VapC	Toxin
GJE11_RS23695	24998..27160	-	2163	WP_000009318.1	type IV conjugative transfer system coupling protein TraD	-
GJE11_RS23700	27537..28268	-	732	WP_000782438.1	complement resistance protein TraT	-
GJE11_RS23705	28304..28798	-	495	WP_010999946.1	entry exclusion protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Non-Mobilizable plasmid	-	-	1..93865	93865

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Hok/gef cell toxic protein (7-46)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 133 a.a.
• Molecular weight: 17065.17 Da
• Isoelectric Point: 12.9205

>T143094 WP_000911322.1 NZ_CP045950:24591-24989 [Salmonella enterica subsp. enterica serovar Typhimurium]
KKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKK
KKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKK

Nucleotide

• Length: 399 bp

>T143094 NZ_CP060940:c50262-50110 [Escherichia coli]
ATGCCACAGCGAACGTTTTTAATGATGTTAATCGTCGTCTGTGTGACGATTCTGTGTTTTGTCTGGATGGTGAGGGATTC
GCTTTGCGGACTCCGGCTCCAGCAGGGAAACACAGTGCTTGTGGCAACGTTAGCCTACGAAGTTAAACGTTAA

Antitoxin

Protein

• Length: 76 a.a.
• Molecular weight: 9759.25 Da
• Isoelectric Point: 12.6750

>AT143094 WP_000450265.1 NZ_CP045950:24364-24591 [Salmonella enterica subsp. enterica serovar Typhimurium]
KKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKK

Nucleotide

• Length: 228 bp

>AT143094 NZ_CP060940:50314-50374 [Escherichia coli]
GAGGCATTACAGTAGAGCCCTTGGTTGATTGATAAAAAAATCTCCAGGGGCTTTCTGCTGT