Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | relBE/ParE-RelB |
| Location | 2394870..2395396 | Replicon | chromosome |
| Accession | NZ_CP045941 | ||
| Organism | Shigella flexneri 2a strain AUSMDU00010535 | ||
Toxin (Protein)
| Gene name | relE | Uniprot ID | S1EXL1 |
| Locus tag | GJE14_RS11925 | Protein ID | WP_000323025.1 |
| Coordinates | 2395109..2395396 (+) | Length | 96 a.a. |
Antitoxin (Protein)
| Gene name | relB | Uniprot ID | S1F6D3 |
| Locus tag | GJE14_RS11920 | Protein ID | WP_000534858.1 |
| Coordinates | 2394870..2395109 (+) | Length | 80 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| GJE14_RS11895 (2390518) | 2390518..2390721 | + | 204 | WP_000214712.1 | putative selenium delivery protein YdfZ | - |
| GJE14_RS11900 (2390757) | 2390757..2392217 | - | 1461 | WP_000527804.1 | mannitol dehydrogenase family protein | - |
| GJE14_RS11905 (2392306) | 2392306..2393325 | - | 1020 | Protein_2330 | MHS family MFS transporter YdfJ | - |
| GJE14_RS11910 (2393387) | 2393387..2394543 | + | 1157 | WP_094105058.1 | IS3-like element IS600 family transposase | - |
| GJE14_RS11915 (2394540) | 2394540..2394845 | - | 306 | WP_071818640.1 | hypothetical protein | - |
| GJE14_RS11920 (2394870) | 2394870..2395109 | + | 240 | WP_000534858.1 | type II toxin-antitoxin system antitoxin RelB | Antitoxin |
| GJE14_RS11925 (2395109) | 2395109..2395396 | + | 288 | WP_000323025.1 | type II toxin-antitoxin system mRNA interferase RelE | Toxin |
| GJE14_RS11930 (2395468) | 2395468..2395623 | + | 156 | WP_000813254.1 | type I toxin-antitoxin system toxin HokD | - |
| GJE14_RS11935 (2395841) | 2395841..2396092 | + | 252 | WP_000980987.1 | protein Rem | - |
| GJE14_RS11940 (2396159) | 2396159..2396437 | + | 279 | Protein_2337 | hypothetical protein | - |
| GJE14_RS11945 (2396439) | 2396439..2397488 | + | 1050 | WP_001265249.1 | DUF968 domain-containing protein | - |
| GJE14_RS11950 (2397501) | 2397501..2397857 | + | 357 | WP_000904111.1 | RusA family crossover junction endodeoxyribonuclease | - |
| GJE14_RS11955 (2397872) | 2397872..2398693 | + | 822 | WP_000762882.1 | antitermination protein | - |
| GJE14_RS11970 (2399614) | 2399614..2399722 | + | 109 | Protein_2341 | DUF3927 family protein | - |
| GJE14_RS11975 (2400003) | 2400003..2400338 | - | 336 | WP_000871291.1 | anti-adapter protein IraM | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Prophage | - | - | 2384352..2408655 | 24303 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 96 a.a. Molecular weight: 11225.22 Da Isoelectric Point: 10.1967
>T143077 WP_000323025.1 NZ_CP045941:2395109-2395396 [Shigella flexneri 2a]
MAYFLDFDERALKEWRKLGSTVREQLKKKLVEVLESPRIEANKLRGMPDCYKIKLRSSGYRLVYQVIDEKVVVFVISVGK
RERSEVYSEAVKRIL
MAYFLDFDERALKEWRKLGSTVREQLKKKLVEVLESPRIEANKLRGMPDCYKIKLRSSGYRLVYQVIDEKVVVFVISVGK
RERSEVYSEAVKRIL
Download Length: 288 bp
>T143077 NZ_CP060938:1307685-1307999 [Escherichia coli]
ATGCACCTGATAACTCAAAAAGCATTGAAAGATGCTGCGGAAAAATACCCGCAACATAAAACGGAGTTGGTGGCTCTGGG
GAACACGATTGCTAAGGGATATTTCAAAAAACCTGAGTCATTAAAAGCAGTATTCCCATCTCTGGATAACTTCAAATATC
TGGATAAGCATTATGTTTTCAATGTTGGGGGCAATGAATTACGTGTTGTAGCAATGGTCTTTTTTGAATCGCAAAAGTGC
TACATACGTGAAGTTATGACGCATAAAGAATACGATTTCTTTACCGCTGTTCATCGTACTAAGGGGAAAAAATGA
ATGCACCTGATAACTCAAAAAGCATTGAAAGATGCTGCGGAAAAATACCCGCAACATAAAACGGAGTTGGTGGCTCTGGG
GAACACGATTGCTAAGGGATATTTCAAAAAACCTGAGTCATTAAAAGCAGTATTCCCATCTCTGGATAACTTCAAATATC
TGGATAAGCATTATGTTTTCAATGTTGGGGGCAATGAATTACGTGTTGTAGCAATGGTCTTTTTTGAATCGCAAAAGTGC
TACATACGTGAAGTTATGACGCATAAAGAATACGATTTCTTTACCGCTGTTCATCGTACTAAGGGGAAAAAATGA
Antitoxin
Download Length: 80 a.a. Molecular weight: 9071.48 Da Isoelectric Point: 4.5230
>AT143077 WP_000534858.1 NZ_CP045941:2394870-2395109 [Shigella flexneri 2a]
MGSINLRIDDELKARSYAALEKMGVTPSEALRLMLEYIADNERLPFKQTLLSDEDAELVEIVKERLRNPKPVRVTLDEL
MGSINLRIDDELKARSYAALEKMGVTPSEALRLMLEYIADNERLPFKQTLLSDEDAELVEIVKERLRNPKPVRVTLDEL
Download Length: 240 bp
>AT143077 NZ_CP060938:1307996-1308412 [Escherichia coli]
ATGATTGCGATTGCCGACATCTTGCAAGCAGGAGAAAAGCTAACTGCTGTGGCACCTTTTCTGGCGGGTATTCAGAACGA
GGAACAATACACCCAGGCGCTGGAACTGGTAGATCATCTGCTGCTCAACGATCCTGAAAACCCCTTGCTGGATCTGGTGT
GTGCCAAAATAACCGCGTGGGAAGAATCAGCGCCCGAATTTGCGGAATTTAATGCCATGGCTCAAGCCATGCCTGGCGGT
ATAGCCGTGATTCGTACCCTTATGGATCAATATGGTTTAACCCTTTCCGATCTGCCGGAAATTGGCAGTAAATCTATGGT
GTCACGCGTTTTGAGCGGGAAGAGGAAATTAACGCTGGAACACGCTAAAAAATTGGCAACGCGATTCGGCATTTCTCCCG
CCTTGTTTATTGATTAA
ATGATTGCGATTGCCGACATCTTGCAAGCAGGAGAAAAGCTAACTGCTGTGGCACCTTTTCTGGCGGGTATTCAGAACGA
GGAACAATACACCCAGGCGCTGGAACTGGTAGATCATCTGCTGCTCAACGATCCTGAAAACCCCTTGCTGGATCTGGTGT
GTGCCAAAATAACCGCGTGGGAAGAATCAGCGCCCGAATTTGCGGAATTTAATGCCATGGCTCAAGCCATGCCTGGCGGT
ATAGCCGTGATTCGTACCCTTATGGATCAATATGGTTTAACCCTTTCCGATCTGCCGGAAATTGGCAGTAAATCTATGGT
GTCACGCGTTTTGAGCGGGAAGAGGAAATTAACGCTGGAACACGCTAAAAAATTGGCAACGCGATTCGGCATTTCTCCCG
CCTTGTTTATTGATTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|