143062

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsxAB/Xre(antitoxin)
Location 6836..7337 Replicon plasmid pAUSMDU00010534_03
Accession NZ_CP045935
Organism Shigella sonnei strain AUSMDU00010534

Toxin (Protein)


Gene name TsxA Uniprot ID H1ZXU8
Locus tag GJE15_RS25290 Protein ID WP_000702247.1
Coordinates 6836..7096 (+) Length 87 a.a.

Antitoxin (Protein)


Gene name TsxB Uniprot ID -
Locus tag GJE15_RS25295 Protein ID WP_001132407.1
Coordinates 7086..7337 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GJE15_RS26355 2375..2527 + 153 Protein_1 DUF5431 family protein -
GJE15_RS25250 (GJE15_25250) 2472..2594 + 123 WP_223202818.1 Hok/Gef family protein -
GJE15_RS25255 (GJE15_25255) 2744..3340 + 597 WP_000125164.1 ProQ/FINO family protein -
GJE15_RS26360 3358..3642 - 285 WP_001162371.1 hypothetical protein -
GJE15_RS25265 (GJE15_25265) 3716..4381 - 666 WP_000532148.1 division plane positioning ATPase MipZ -
GJE15_RS25270 (GJE15_25270) 4980..5309 + 330 WP_000855119.1 hypothetical protein -
GJE15_RS26365 5417..5563 - 147 WP_001356709.1 hypothetical protein -
GJE15_RS25275 (GJE15_25275) 5889..6212 + 324 WP_000427402.1 hypothetical protein -
GJE15_RS25280 (GJE15_25280) 6253..6462 + 210 WP_000866037.1 hypothetical protein -
GJE15_RS25285 (GJE15_25285) 6560..6784 + 225 WP_000814384.1 hypothetical protein -
GJE15_RS25290 (GJE15_25290) 6836..7096 + 261 WP_000702247.1 hypothetical protein Toxin
GJE15_RS25295 (GJE15_25295) 7086..7337 + 252 WP_001132407.1 transcriptional regulator Antitoxin
GJE15_RS25300 (GJE15_25300) 7887..8165 + 279 WP_135171922.1 cobalamin biosynthesis protein CbiX -
GJE15_RS26370 8553..8996 - 444 WP_000192626.1 hypothetical protein -
GJE15_RS25310 (GJE15_25310) 9293..9475 + 183 WP_000833470.1 type II toxin-antitoxin system HicA family toxin -
GJE15_RS25315 (GJE15_25315) 9500..9937 + 438 WP_000466318.1 type II toxin-antitoxin system HicB family antitoxin -
GJE15_RS25320 (GJE15_25320) 10068..10388 - 321 WP_135171923.1 hypothetical protein -
GJE15_RS25325 (GJE15_25325) 10392..10679 - 288 WP_000212745.1 hypothetical protein -
GJE15_RS26375 11011..11133 - 123 Protein_19 hypothetical protein -
GJE15_RS25335 (GJE15_25335) 11153..11752 - 600 WP_000091423.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Mobilizable plasmid - - 1..57073 57073


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Cro/C1-type helix-turn-helix domain

(8-37)


Sequences

Toxin        


Download         Length: 87 a.a.        Molecular weight: 9817.29 Da        Isoelectric Point: 10.0665

>T143062 WP_000702247.1 NZ_CP045935:6836-7096 [Shigella sonnei]
MKIRKGDRQYYLNKEGDTFHLVKRVKTFSKSATLGKTKATVKTVADLVFHEKAFDTIDFASDGLRENDKEIVSMMIQEMS
EGKNAK

Download         Length: 261 bp

>T143062 NZ_CP060933:3011384-3011491 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCATGACTTTCTGGCACGACCTGGCAGCACCGATCCTGGCGGGGATTATTACCGCAGCGAT
TGTCAGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9404.77 Da        Isoelectric Point: 9.8120

>AT143062 WP_001132407.1 NZ_CP045935:7086-7337 [Shigella sonnei]
MPNENTPENIKRLRQKIGLTQKECAEIFSMSPRTWRRKEEPVGTASGTALTPVEFKFLLLLAGEHPDYVLCKRNKKNSDS
GSN

Download         Length: 252 bp

>AT143062 NZ_CP060933:c3011336-3011269 [Escherichia coli]
GTCTGGTTTCAAGATTAGCCCCCGTTTTGTTGTCAGGTTAAACCTCTCAACGTGCGGGGGTTTTCTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1P8DNC0

Antitoxin

Source ID Structure

References