Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | paaR-paaA-parE/- |
| Location | 2152940..2153424 | Replicon | chromosome |
| Accession | NZ_CP045932 | ||
| Organism | Shigella sonnei strain AUSMDU00010534 | ||
Toxin (Protein)
| Gene name | parE_1 | Uniprot ID | A0A377EAU1 |
| Locus tag | GJE15_RS10920 | Protein ID | WP_014334020.1 |
| Coordinates | 2152940..2153230 (-) | Length | 97 a.a. |
Antitoxin (Protein)
| Gene name | paaA | Uniprot ID | A0A376K4R9 |
| Locus tag | GJE15_RS10925 | Protein ID | WP_005142544.1 |
| Coordinates | 2153230..2153424 (-) | Length | 65 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| GJE15_RS10890 (2148140) | 2148140..2149216 | - | 1077 | Protein_2156 | molybdopterin dinucleotide binding domain-containing protein | - |
| GJE15_RS10895 (2149274) | 2149274..2149971 | + | 698 | WP_094096600.1 | IS1-like element IS1A family transposase | - |
| GJE15_RS10900 (2149965) | 2149965..2150753 | - | 789 | Protein_2158 | Rha family transcriptional regulator | - |
| GJE15_RS10905 (2151286) | 2151286..2151983 | + | 698 | WP_094096600.1 | IS1-like element IS1A family transposase | - |
| GJE15_RS10910 (2152131) | 2152131..2152496 | - | 366 | WP_024174355.1 | hypothetical protein | - |
| GJE15_RS10915 (2152508) | 2152508..2152660 | - | 153 | WP_000379558.1 | DUF1391 family protein | - |
| GJE15_RS10920 (2152940) | 2152940..2153230 | - | 291 | WP_014334020.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
| GJE15_RS10925 (2153230) | 2153230..2153424 | - | 195 | WP_005142544.1 | hypothetical protein | Antitoxin |
| GJE15_RS10930 (2153444) | 2153444..2153929 | - | 486 | WP_053002468.1 | helix-turn-helix domain-containing protein | - |
| GJE15_RS10935 (2154056) | 2154056..2154319 | + | 264 | WP_001048456.1 | helix-turn-helix transcriptional regulator | - |
| GJE15_RS10940 (2154316) | 2154316..2154741 | + | 426 | WP_000693826.1 | toxin YdaT family protein | - |
| GJE15_RS10945 (2154813) | 2154813..2155877 | + | 1065 | WP_001262380.1 | hypothetical protein | - |
| GJE15_RS10950 (2155884) | 2155884..2156630 | + | 747 | WP_000788740.1 | ATP-binding protein | - |
| GJE15_RS10955 (2156652) | 2156652..2157377 | + | 726 | WP_000450631.1 | DUF1627 domain-containing protein | - |
| GJE15_RS10960 (2157393) | 2157393..2157815 | + | 423 | WP_001151171.1 | DUF977 family protein | - |
| GJE15_RS10965 (2157873) | 2157873..2158229 | + | 357 | WP_005140877.1 | hypothetical protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Integrative and Conjugative Element | - | sodB / rhs/PAAR / rhs/PAAR / rhs/PAAR / rhs/PAAR / vgrG/tssI | 2060325..2288973 | 228648 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 97 a.a. Molecular weight: 11062.93 Da Isoelectric Point: 10.2013
>T143052 WP_014334020.1 NZ_CP045932:c2153230-2152940 [Shigella sonnei]
MLPVLWLPSARDDLRQIVAYIAKENPAAARRMKIRIETSVLPLTEHPYLYPPSERVLGLREIVTHPNYIILYRVTASSIE
VVNIVHSRRQYPGKNS
MLPVLWLPSARDDLRQIVAYIAKENPAAARRMKIRIETSVLPLTEHPYLYPPSERVLGLREIVTHPNYIILYRVTASSIE
VVNIVHSRRQYPGKNS
Download Length: 291 bp
>T143052 NZ_CP060933:928064-928447 [Escherichia coli]
ATGAAAACATTACCTGTATTACCCGGGCAGGCGGCCAGTTCACGCCCGTCTCCGGTTGAAATCTGGCAGACACTGCTCAC
CCGACTGCTGGACCAGCACTACGGCCTTACGCTGAATGACACACCGTTCGCCGATGAACGTGTGATTGAGCAGCATATTG
AAGCTGGCATTTCACTGTGTGATGCGGTGAACTTTCTCGTTGAAAAATACGCACTGGTACGTACCGACCAGCCGGGATTC
AGCGCCTGTACCCGCTCTCAGTTAATAAACAGTATTGATATTCTCCGGGCTCGCCGGGCAACCGGCCTGATGACCCGCGA
CAATTACAGAACGGTAAATAACATTACCCTGGGTAAGCATCAGGAGTCGAAACGATGCAACTGA
ATGAAAACATTACCTGTATTACCCGGGCAGGCGGCCAGTTCACGCCCGTCTCCGGTTGAAATCTGGCAGACACTGCTCAC
CCGACTGCTGGACCAGCACTACGGCCTTACGCTGAATGACACACCGTTCGCCGATGAACGTGTGATTGAGCAGCATATTG
AAGCTGGCATTTCACTGTGTGATGCGGTGAACTTTCTCGTTGAAAAATACGCACTGGTACGTACCGACCAGCCGGGATTC
AGCGCCTGTACCCGCTCTCAGTTAATAAACAGTATTGATATTCTCCGGGCTCGCCGGGCAACCGGCCTGATGACCCGCGA
CAATTACAGAACGGTAAATAACATTACCCTGGGTAAGCATCAGGAGTCGAAACGATGCAACTGA
Antitoxin
Download Length: 65 a.a. Molecular weight: 7097.98 Da Isoelectric Point: 4.1759
>AT143052 WP_005142544.1 NZ_CP045932:c2153424-2153230 [Shigella sonnei]
MSTVLSPMVSEFETVEQENSYNEWLRAKVAASLADPRPAIPHDEVMAEMEQIIAQIAAATHRGE
MSTVLSPMVSEFETVEQENSYNEWLRAKVAASLADPRPAIPHDEVMAEMEQIIAQIAAATHRGE
Download Length: 195 bp
>AT143052 NZ_CP060933:927606-927974 [Escherichia coli]
GTGTCAGACACATTCTCCGGGACAACGCATCCCGATGACAATCACGACCGCCCCTGGTGGGGGCTGCCCTGTACCGTGAC
GCCCTGTTTCGGGGCACGTCTGGTGCAGGAGGGTAACCGGTTGCATTACCTTACAGACCGCGCCGGTATCAGAGGCCGGT
TCAGCGATGCGGATGCGAACCATCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAACTCATGCTCACCAGCAGT
GAACTGAATCCCCACCGTCAGAATACCGTCACGCTGTATGTTAAAGGGCTGACCTGCCATGCGGACACCCTCGGCAGCTG
TGGTTACGTTTATCTGGCTGTTTATCCGACGCCCGAAATGAAAAATTAA
GTGTCAGACACATTCTCCGGGACAACGCATCCCGATGACAATCACGACCGCCCCTGGTGGGGGCTGCCCTGTACCGTGAC
GCCCTGTTTCGGGGCACGTCTGGTGCAGGAGGGTAACCGGTTGCATTACCTTACAGACCGCGCCGGTATCAGAGGCCGGT
TCAGCGATGCGGATGCGAACCATCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAACTCATGCTCACCAGCAGT
GAACTGAATCCCCACCGTCAGAATACCGTCACGCTGTATGTTAAAGGGCTGACCTGCCATGCGGACACCCTCGGCAGCTG
TGGTTACGTTTATCTGGCTGTTTATCCGACGCCCGAAATGAAAAATTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A377EAU1 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A376K4R9 |