Detailed information of TA system TA143039

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicA-HicB
• Location: 1634397..1635059
• Replicon: chromosome
• Accession: NZ_CP045931
• Organism: Streptococcus pneumoniae strain AUSMDU00010538

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: -
• Locus tag: GJE16_RS08230
• Protein ID: WP_000192221.1
• Coordinates: 1634886..1635059 (-)
• Length: 58 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: G0IC64
• Locus tag: GJE16_RS08225
• Protein ID: WP_000961810.1
• Coordinates: 1634397..1634849 (-)
• Length: 151 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
GJE16_RS08200	1630287..1631030	-	744	WP_001188207.1	16S rRNA (uracil(1498)-N(3))-methyltransferase	-
GJE16_RS08205	1631032..1631982	-	951	WP_000451134.1	50S ribosomal protein L11 methyltransferase	-
GJE16_RS08210	1632120..1632548	-	429	WP_000401988.1	NUDIX hydrolase	-
GJE16_RS08215	1632550..1633617	-	1068	WP_000719721.1	M50 family metallopeptidase	-
GJE16_RS08220	1633636..1634106	-	471	WP_000257084.1	DUF3013 family protein	-
GJE16_RS08225	1634397..1634849	-	453	WP_000961810.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
GJE16_RS08230	1634886..1635059	-	174	WP_000192221.1	type II toxin-antitoxin system HicA family toxin	Toxin
GJE16_RS08235	1635202..1635381	-	180	WP_001809903.1	hypothetical protein	-
GJE16_RS08240	1635546..1635784	-	239	Protein_1603	hypothetical protein	-
GJE16_RS08245	1636054..1637325	+	1272	WP_001113208.1	replication-associated recombination protein A	-
GJE16_RS08255	1637871..1639190	-	1320	WP_000502548.1	glycoside hydrolase family 32 protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (4-57)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (17-114)

Sequences

Toxin

Protein

• Length: 58 a.a.
• Molecular weight: 6368.47 Da
• Isoelectric Point: 10.8214

>T143039 WP_000192221.1 NZ_CP045931:c1635059-1634886 [Streptococcus pneumoniae]
MTQKEMVKLLTAHGWIKTRGGKGSHIKIEKQGERPITILHGELNKYTERGIGKQAGL

Nucleotide

• Length: 174 bp

>T143039 NZ_CP060928:2329973-2330437 [Escherichia coli]
ATGGATTTTCCACAAAGGGTTAATGGTTGGGCGCTATATGCTCATCCCTGTTTTCAGGAAACCTACGACGCTTTAGTTGC
CGAAGTCGAGACATTAAAGGGAAAAGATCCTGAAAATTATCAGAGAAAAGCCGCCACAAAGTTATTGGCGGTAGTCCATA
AAGTGATTGAGGAGCATATCACGGTCAATCCATCATCACCGGCATTCCGTCATGGCAAGTCGTTAGGCTCTGGGAAAAAT
AAAGACTGGTCACGGGTAAAATTTGGTGCTGGTCGTTATCGTCTCTTCTTTCGTTATAGTGAAAAAGAGAAAGTCATCAT
TCTGGGATGGATGAACGATGAAAACACTCTGCGCACCTACGGTAAAAAAACAGATGCCTATACCGTATTCAGCAAAATGT
TAAAAAGAGGACATCCTCCTGCCGACTGGGAAACCCTCACCCGAGAGACAGAAGAAACCCATTGA

Antitoxin

Protein

• Length: 151 a.a.
• Molecular weight: 16659.46 Da
• Isoelectric Point: 3.7220

>AT143039 WP_000961810.1 NZ_CP045931:c1634849-1634397 [Streptococcus pneumoniae]
MLVTYPALFYYDDTDGTEATYFVHFPDFEYSATQGEGISEALAMGSEWLGITVADLIESDGELPQPSDINSLSLIDNDPF
KDDEDFVSTYDLDKSFISMVSVDVSEYLGSQEPIKKTLTIPKWADKLGREMGLNFSQTLTDAIADKKVQA

Nucleotide

• Length: 453 bp

>AT143039 NZ_CP060928:2329638-2329973 [Escherichia coli]
ATGCCCGCTAATGCTCGCTCTCACGCTGTACTGACCACTGAATCAAAGGTCACGATACGCGGACAAACAACTATCCCCGC
GCCAGTGCGTGAGGCCTTAAAACTGAAGCCAGGCCAGGACAGCATTCATTACGAAATTCTGCCTGGTGGGCAAGTATTTA
TGTGCCGACTGGGAGATGAACAGGAGGATCATACTATGAATGCATTTTTGCGTTTTCTGGATGCAGATATCCAGAACAAC
CCGCAAAAAACTCGTCCATTCAACATTCAACAAGGAAAGAAACTTGTCGCTGGCATGGACGTCAACATTGATGATGAGAT
TGGCGACGACGAATAA

Structures

Antitoxin

• AlphaFold DB: G0IC64