Detailed information of TA system TA143037

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): pezAT/zeta-couple_hipB
• Location: 955433..956670
• Replicon: chromosome
• Accession: NZ_CP045931
• Organism: Streptococcus pneumoniae strain AUSMDU00010538

Toxin (Protein)

• Gene name: pezT
• Uniprot ID: -
• Locus tag: GJE16_RS04930
• Protein ID: WP_000405365.1
• Coordinates: 955909..956670 (+)
• Length: 254 a.a.

Antitoxin (Protein)

• Gene name: pezA
• Uniprot ID: -
• Locus tag: GJE16_RS04925
• Protein ID: WP_000579599.1
• Coordinates: 955433..955909 (+)
• Length: 159 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
GJE16_RS04905	950506..951360	+	855	WP_000900017.1	ADP-ribosylglycohydrolase family protein	-
GJE16_RS04910	951472..952356	+	885	WP_000710115.1	diacylglycerol kinase family lipid kinase	-
GJE16_RS04915	952519..954258	+	1740	WP_000423466.1	glycoside hydrolase family 13 protein	-
GJE16_RS04920	954533..954988	+	456	WP_000500465.1	hypothetical protein	-
GJE16_RS04925	955433..955909	+	477	WP_000579599.1	helix-turn-helix domain-containing protein	Antitoxin
GJE16_RS04930	955909..956670	+	762	WP_000405365.1	zeta toxin family protein	Toxin
GJE16_RS04935	956698..957854	+	1157	Protein_956	hypothetical protein	-
GJE16_RS04940	958673..959032	+	360	WP_000003745.1	hypothetical protein	-
GJE16_RS04945	959042..959407	+	366	WP_000263051.1	MobC family plasmid mobilization relaxosome protein	-
GJE16_RS04950	959394..961259	+	1866	WP_000261794.1	relaxase/mobilization nuclease domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	935644..968206	32562

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Zeta toxin domain (25-215)

Antitoxin

• Cro/C1-type helix-turn-helix domain (3-60)

Sequences

Toxin

Protein

• Length: 254 a.a.
• Molecular weight: 29060.05 Da
• Isoelectric Point: 6.8511

>T143037 WP_000405365.1 NZ_CP045931:955909-956670 [Streptococcus pneumoniae]
MEIQDYTDSEFKHALARNLRSLTRGKKSSKQPIAILLGGQSGAGKTTIHRIKQKEFQGNIVIIDGDSFRSQHPHYLELQQ
EYGKDSVEYTKDFAGKMVESLVTKLSSLRYNLLIEGTLRTVDVPKKTAQLLKNKGYEVQLALIATKPELSYLSTLIRYEE
LYIINPNQARATPKEHHDFIVNHLVDNTRQLEELAIFESIQIYQRDRSCVYDSKENTTSAADVLQELLFGEWSQVEKEML
QVGEKRLNELLEK

Nucleotide

• Length: 762 bp

>T143037 NZ_CP060928:c2222539-2222243 [Escherichia coli]
ATGGAAAAACGCACACCACATACACGTTTGAGTCAGGTTAAAAAACTTGTCAATGCCGGGCAAGTTCGTACAACACGTAG
TGCCCTGTTAAATGCAGATGAGTTAGGTTTGGATTTTGATGGTATGTGTAATGTTATCATTGGATTATCAGAGAGCGACT
TTTATAAAAGCATGACCACCTACTCTGATCATACTATCTGGCAGGATGTTTACAGACCCAGGCTTGTTACAGGCCAGGTT
TATCTTAAAATTACGGTAATTCATGACGTACTGATCGTCTCGTTTAAGGAGAAGTAA

Antitoxin

Protein

• Length: 159 a.a.
• Molecular weight: 18251.60 Da
• Isoelectric Point: 4.3571

>AT143037 WP_000579599.1 NZ_CP045931:955433-955909 [Streptococcus pneumoniae]
MIGKNIKSLRKTHDLTQDDFSRIVGISRNSLSRYENGTSSVSTELIDIICQKFNVSYVDIVGEDKMLNPVEDYELTLKIE
IVKERGANLLSRLYRYQDSQGISIDDESNPWILMSDDLSDLIHTNIYLVETFDEIERYSGYLDGIERMLEISEKRMVA

Nucleotide

• Length: 477 bp

>AT143037 NZ_CP060928:c2222241-2221846 [Escherichia coli]
ATGAAATGTCCGGTTTGCCACCAGGGAGAAATGGTTTCTGGCATTAAAGATATTCCATACACCTTCCGTGGACGAAAAAC
AGTATTGAAAGGTATCCACGGTTTATATTGTGTCCATTGCGAAGAGAGCATCATGAATAAAGAAGAGTCAGATGCTTTCA
TGGCGCAAGTAAAGGCATTTCGGGCTTCGGTGAATGCCGAAACAGTGGCACCTGAATTTATAGTGAAGGTTCGAAAAAAG
CTCTCTCTTACCCAAAAAGAGGCAAGCGAAATTTTTGGGGGAGGTGTAAATGCGTTTTCGCGTTACGAAAAAGGCAATGC
CCAACCTCATCCTTCCACAATCAAACTTTTACGTGTTCTGGATAAGCATCCAGAACTATTGAATGAAATCCGTTAA