Detailed information of TA system TA143036

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): parDE/RelB(antitoxin)
• Location: 1512584..1513196
• Replicon: chromosome
• Accession: NZ_CP045930
• Organism: Streptococcus pyogenes strain AUSMDU00010539

Toxin (Protein)

• Gene name: parE
• Uniprot ID: -
• Locus tag: GJE17_RS07515
• Protein ID: WP_002994716.1
• Coordinates: 1512861..1513196 (+)
• Length: 112 a.a.

Antitoxin (Protein)

• Gene name: parD
• Uniprot ID: Q5X9X9
• Locus tag: GJE17_RS07510
• Protein ID: WP_002988079.1
• Coordinates: 1512584..1512871 (+)
• Length: 96 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
GJE17_RS07485	1507774..1508757	-	984	WP_031488719.1	tagatose-bisphosphate aldolase	-
GJE17_RS07490	1508761..1509690	-	930	WP_031488720.1	tagatose-6-phosphate kinase	-
GJE17_RS07495	1509738..1510253	-	516	WP_002991700.1	galactose-6-phosphate isomerase subunit LacB	-
GJE17_RS07500	1510288..1510716	-	429	WP_014635709.1	galactose-6-phosphate isomerase subunit LacA	-
GJE17_RS07505	1511161..1511934	+	774	WP_002982738.1	DeoR/GlpR family DNA-binding transcription regulator	-
GJE17_RS07510	1512584..1512871	+	288	WP_002988079.1	DNA-damage-inducible protein J	Antitoxin
GJE17_RS07515	1512861..1513196	+	336	WP_002994716.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
GJE17_RS08650	1513348..1513818	+	471	WP_021733374.1	site-specific integrase	-
GJE17_RS08655	1513781..1514329	+	549	WP_180372715.1	site-specific integrase	-
GJE17_RS07530	1514461..1514853	-	393	WP_002982716.1	30S ribosomal protein S9	-
GJE17_RS07535	1514874..1515320	-	447	WP_002982710.1	50S ribosomal protein L13	-
GJE17_RS07540	1515538..1515744	-	207	WP_002982695.1	helix-turn-helix transcriptional regulator	-
GJE17_RS07545	1515741..1516247	-	507	WP_002988070.1	hypothetical protein	-
GJE17_RS07550	1516383..1517243	-	861	WP_011529009.1	DegV family protein	-
GJE17_RS07555	1517340..1517858	-	519	WP_002982682.1	NYN domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (7-104)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 112 a.a.
• Molecular weight: 13154.89 Da
• Isoelectric Point: 5.6157

>T143036 WP_002994716.1 NZ_CP045930:1512861-1513196 [Streptococcus pyogenes]
MDYKKYQIIYAPDVLEKLKEIRDYISQNYSSTSGQHKMEQIISDIEKLEVFPEVGFDADEKYGSKISHYHSTKGYTLSKD
YIVLYHIEGEENRVVIDYLLPTRSDYIKLFK

Nucleotide

• Length: 336 bp

>T143036 NZ_CP060928:c2114109-2113702 [Escherichia coli]
GTGGTCCTGTGGCAATCTGATTTGCGCGTCTCCTGGCGCGCACAGTGGCTTTCCTTGCTGATTCATGGGCTGGTTGCCGC
TGTTATTTTACTCATGCCCTGGCCACTCAGTTACACCCCGTTATGGATGGTGTTACTTTCGCTGGTGGTGTTTGATTGCG
TTCGCAGCCAGCGGCGTATTAATGCTCGCCAGGGGGAAATTCGCTTGTTGATGGACGGGCGTTTGCGTTGGCAAGGGCAG
GAGTGGAGCATCGTCAAAGCACCGTGGATGATTAAGAGCGGCATGATGCTGCGTTTACGTTCTGATGGCGGTAAACGGCA
ACATTTATGGCTGGCAGCCGACAGCATGGACGAAGCTGAATGGCGGGATTTACGGCGGATTTTGTTGCAACAAGAGACGC
AAAGATAA

Antitoxin

Protein

• Length: 96 a.a.
• Molecular weight: 10934.56 Da
• Isoelectric Point: 5.2318

>AT143036 WP_002988079.1 NZ_CP045930:1512584-1512871 [Streptococcus pyogenes]
MTTVKKNRAVTFQANKELVSEAMTVLNKKNLTLSSALRLFLQNVVVTNEVDLLTEEELEKEKLFKQFQAEINKNIEDVRQ
GKFYTSEEVRAELGL

Nucleotide

• Length: 288 bp

>AT143036 NZ_CP060928:c2114356-2114090 [Escherichia coli]
ATGGACATTAACAACAAAGCCCGCATTCATTGGGCATGCCGCCGTGGTATGCGCGAACTCGATATTTCAATCATGCCGTT
TTTCGAACATGAGTACGACAGCTTAAGCGATGACGAAAAACGCATCTTTATTCGTCTGCTGGAATGTGACGATCCGGACC
TGTTTAACTGGCTGATGAATCACGGTAAACCGGCCGATGCAGAACTGGAAATGATGGTCCGACTCATCCAGACACGGAAC
CGGGAACGTGGTCCTGTGGCAATCTGA

Structures

Antitoxin

• AlphaFold DB: A0A4U7GX94