Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN-CcdA
Location 4753760..4754406 Replicon chromosome
Accession NZ_CP045929
Organism Saccharopolyspora coralli strain E2A

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag GIY23_RS22225 Protein ID WP_154079061.1
Coordinates 4753993..4754406 (+) Length 138 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag GIY23_RS22220 Protein ID WP_154078428.1
Coordinates 4753760..4753975 (+) Length 72 a.a.

Genomic Context

GIY23_RS22205GIY23_RS22210GIY23_RS22220GIY23_RS22225GIY23_RS22230GIY23_RS22235GIY23_RS22240GIY23_RS22215
Location: 4750149..4750892 (744 bp)
Type: Others
Protein ID: WP_154078425.1
Location: 4751038..4752228 (1191 bp)
Type: Others
Protein ID: WP_154078426.1
Location: 4753760..4753975 (216 bp)
Type: Antitoxin
Protein ID: WP_154078428.1
Location: 4753993..4754406 (414 bp)
Type: Toxin
Protein ID: WP_154079061.1
Location: 4754452..4756308 (1857 bp)
Type: Others
Protein ID: WP_154078429.1
Location: 4756380..4756700 (321 bp)
Type: Others
Protein ID: WP_154078430.1
Location: 4757368..4759011 (1644 bp)
Type: Others
Protein ID: WP_154079062.1
Location: 4752882..4753598 (717 bp)
Type: Others
Protein ID: WP_154078427.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
GIY23_RS222054750149..4750892+744WP_154078425.1MerR family transcriptional regulator-
GIY23_RS222104751038..4752228+1191WP_154078426.1ATP-binding protein-
GIY23_RS222154752882..4753598-717WP_154078427.1hypothetical protein-
GIY23_RS222204753760..4753975+216WP_154078428.1type II toxin-antitoxin system CcdA family antitoxinAntitoxin
GIY23_RS222254753993..4754406+414WP_154079061.1PIN domain-containing proteinToxin
GIY23_RS222304754452..4756308+1857WP_154078429.1NHL domain-containing thioredoxin family protein-
GIY23_RS222354756380..4756700+321WP_154078430.1co-chaperone GroES-
GIY23_RS222404757368..4759011+1644WP_154079062.1VanW family protein-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
No matching records found


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Pae0151-like, PIN domain

(2-121)

Antitoxin

Post-segregation antitoxin CcdA

(3-45)


Sequences

Toxin        


Download         Length: 138 a.a.        Molecular weight: 14780.04 Da        Isoelectric Point: 6.2148

>T143035 WP_154079061.1 NZ_CP045929:4753993-4754406 [Saccharopolyspora coralli]
VVLDASVAVDLLTGTDCAPAASARLAGTELHAPAHLDAEVLSALGRMQRAGDLAAVDVELAIDRLAVMPVTRHPLPNLLT
GAWARRAYVRLLDGLYIALAEHLGLRVLTTDLRLARACPELTDTLHRPTEQRDVRHE

Download         Length: 414 bp

>T143035 NZ_CP060928:c1976653-1976318 [Escherichia coli]
ATGGTAAGCCGATACGTACCCGATATGGGCGATCTGATTTGGGTTGATTTTGACCCGACAAAAGGTAGCGAGCAAGCTCG
ACATCGTCCAGCTGTTGTCCTGAGTCCTTTCATGTACAACAACAAAACAGGTATGTGTCTGTGTGTTCCTTGTACAACGC
AATCAAAAGGATATCCGTTCGAAGTTGTTTTATCCGGTCAGGAACGTGATGGCGTAGCGTTAGCTGATCAGGTAAAAAGT
ATCGCCTGGCGGGCAAGAGGAGCAACGAAGAAAGGAACAGTTGCCCCAGAGGAATTACAACTCATTAAAGCCAAAATTAA
CGTACTGATTGGGTAG

Antitoxin


Download         Length: 72 a.a.        Molecular weight: 7676.69 Da        Isoelectric Point: 4.9681

>AT143035 WP_154078428.1 NZ_CP045929:4753760-4753975 [Saccharopolyspora coralli]
MTRMNVWVPDDLAARAREARLNVSALTQAAIAAELARTATDAWLATLPAPRGLTHEASMRALDDAREEFGA

Download         Length: 216 bp

>AT143035 NZ_CP060928:c1976901-1976653 [Escherichia coli]
ATGATCCACAGTAGCGTAAAGCGTTGGGGAAATTCACCGGCGGTGCGGATCCCGACTACGTTAATGCAGGCGCTCAATCT
GAATATTGATGATGAAGTGAAGATTGACCTGGTGGATGGCAAATTAATTATTGAGCCAGTGCGTAAAGAGCCCGTATTTA
CGCTTGCTGAACTGGTCAACGACATCACGCCGGAAAACCTCCACGAGAATATCGACTGGGGAGAGCCGAAAGATAAGGAA
GTCTGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
No matching records found

Antitoxin

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Source
ID
Structure
No matching records found

References