Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VapB
Location 3809403..3810019 Replicon chromosome
Accession NZ_CP045929
Organism Saccharopolyspora coralli strain E2A

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag GIY23_RS17735 Protein ID WP_154078943.1
Coordinates 3809403..3809807 (-) Length 135 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag GIY23_RS17740 Protein ID WP_154077690.1
Coordinates 3809804..3810019 (-) Length 72 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GIY23_RS17710 3804781..3806286 - 1506 WP_154077685.1 Asp-tRNA(Asn)/Glu-tRNA(Gln) amidotransferase subunit GatB -
GIY23_RS17715 3806283..3806477 - 195 WP_154077686.1 hypothetical protein -
GIY23_RS17720 3806474..3807988 - 1515 WP_154077687.1 Asp-tRNA(Asn)/Glu-tRNA(Gln) amidotransferase subunit GatA -
GIY23_RS17725 3807988..3808287 - 300 WP_154077688.1 Asp-tRNA(Asn)/Glu-tRNA(Gln) amidotransferase subunit GatC -
GIY23_RS17730 3808713..3809366 + 654 WP_187352187.1 amino acid-binding protein -
GIY23_RS17735 3809403..3809807 - 405 WP_154078943.1 PIN domain nuclease Toxin
GIY23_RS17740 3809804..3810019 - 216 WP_154077690.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
GIY23_RS17745 3810047..3810538 - 492 WP_154077691.1 GNAT family N-acetyltransferase -
GIY23_RS17750 3810574..3812760 - 2187 WP_154077692.1 NAD-dependent DNA ligase LigA -
GIY23_RS17755 3812946..3813620 - 675 WP_154077693.1 hypothetical protein -
GIY23_RS17760 3813744..3814787 - 1044 WP_154078944.1 methionine synthase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-121)

Antitoxin

Bacterial antitoxin of type II TA system, VapB

(3-35)


Sequences

Toxin        


Download         Length: 135 a.a.        Molecular weight: 14479.62 Da        Isoelectric Point: 4.7105

>T143034 WP_154078943.1 NZ_CP045929:c3809807-3809403 [Saccharopolyspora coralli]
VILVDTSVWIEWLRATGSTADKAVQELRGEPQLLATTPPVRMEVLAGVSPRRVAMVSDVLDSAVPLAVESYTDFDTAAEL
FRAARATGRTVRSLLDCVIAAVAIREQATLLHRDHDFVVLSEVAPGLVCHSTVE

Download         Length: 405 bp

>T143034 NZ_CP060928:c1186745-1186494 [Escherichia coli]
ATGCGTACAATTAGCTACAGCGAAGCGCGTCAGAATTTGTCGGCAACAATGATGAAAGCCGTTGAAGATCATGCCCCGAT
CCTTATTACTCGTCAGAATGGAGAGGCTTGTGTTCTGATGTCACTCGAAGAATACAACTCGCTGGAAGAGACGGCTTATC
TACTGCGCTCCCCCGCTAACGCCCGGAGATTGATGGACTCAATCGATAGCCTGAAATCAGGCAAAGGAACAGAAAAGGAC
ATTATTGAGTGA

Antitoxin


Download         Length: 72 a.a.        Molecular weight: 8202.27 Da        Isoelectric Point: 4.6286

>AT143034 WP_154077690.1 NZ_CP045929:c3810019-3809804 [Saccharopolyspora coralli]
MTRTNIDIDDELIANVMDRYRLGSKREAVDFALRRVARPRLTTEALESLHGIGFDLDLEELRGGSRVIEWE

Download         Length: 216 bp

>AT143034 NZ_CP060928:c1186497-1186243 [Escherichia coli]
GTGAAACTAATCTGGTCTGAGGAATCATGGGATGATTATCTGTACTGGCAGGAAACAGATAAGCGAATTGTTAAAAAGAT
CAATGAACTTATCAAAGATACCCGCAGAACGCCATTTGAAGGTAAGGGGAAGCCAGAATCCCTGAAACATAATTTGTCAG
GTTTCTGGTCCCGACGCATTACAGAGGAGCACCGTCTGGTATACGCGGTTACCGACGATTCACTGCTCATTGCAGCATGT
CGTTATCATTATTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References