Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VapB
Location 2319889..2320481 Replicon chromosome
Accession NZ_CP045929
Organism Saccharopolyspora coralli strain E2A

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag GIY23_RS11000 Protein ID WP_154076563.1
Coordinates 2319889..2320287 (-) Length 133 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag GIY23_RS11005 Protein ID WP_154076564.1
Coordinates 2320284..2320481 (-) Length 66 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GIY23_RS10970 2315101..2315304 + 204 WP_154075332.1 cold-shock protein -
GIY23_RS10975 2315652..2316029 + 378 WP_154075333.1 STAS domain-containing protein -
GIY23_RS22640 2316029..2316205 + 177 WP_187352008.1 hypothetical protein -
GIY23_RS10980 2316396..2316497 - 102 Protein_2160 glyoxalase -
GIY23_RS10985 2317102..2317746 - 645 WP_154076560.1 TetR/AcrR family transcriptional regulator -
GIY23_RS10990 2317664..2318710 + 1047 WP_154076561.1 SDR family oxidoreductase -
GIY23_RS10995 2318707..2319816 + 1110 WP_154076562.1 hypothetical protein -
GIY23_RS11000 2319889..2320287 - 399 WP_154076563.1 type II toxin-antitoxin system VapC family toxin Toxin
GIY23_RS11005 2320284..2320481 - 198 WP_154076564.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
GIY23_RS11010 2320689..2321674 + 986 Protein_2166 pyridoxal-phosphate dependent enzyme -
GIY23_RS11015 2321711..2322128 - 418 Protein_2167 Tn3 family transposase -
GIY23_RS11020 2322191..2323372 - 1182 WP_154076565.1 hypothetical protein -
GIY23_RS11025 2323483..2324997 - 1515 WP_154078775.1 MFS transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Bacterial antitoxin of type II TA system, VapB

(1-46)


Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 14730.65 Da        Isoelectric Point: 4.9407

>T143033 WP_154076563.1 NZ_CP045929:c2320287-2319889 [Saccharopolyspora coralli]
VILVDTSIWIDHFRSGDAELSRLLDNNAILGHPWVTGEIGLGNLRHRDEVIGLLRGLPRASVADEDEVLKLIDREALYGA
GIGYVDAQLLAASRLTPDARLWTRDKRLLNVTARMELDFQPSSHQLSDPETH

Download         Length: 399 bp

>T143033 NZ_CP060928:c1186497-1186243 [Escherichia coli]
GTGAAACTAATCTGGTCTGAGGAATCATGGGATGATTATCTGTACTGGCAGGAAACAGATAAGCGAATTGTTAAAAAGAT
CAATGAACTTATCAAAGATACCCGCAGAACGCCATTTGAAGGTAAGGGGAAGCCAGAATCCCTGAAACATAATTTGTCAG
GTTTCTGGTCCCGACGCATTACAGAGGAGCACCGTCTGGTATACGCGGTTACCGACGATTCACTGCTCATTGCAGCATGT
CGTTATCATTATTGA

Antitoxin


Download         Length: 66 a.a.        Molecular weight: 7272.27 Da        Isoelectric Point: 11.0376

>AT143033 WP_154076564.1 NZ_CP045929:c2320481-2320284 [Saccharopolyspora coralli]
MRTTLALDDDLLTEAQRLTGTSEKTALVREALRALIERESARRLARLGGTEPSLADVPRRRTQPQ

Download         Length: 198 bp

>AT143033 NZ_CP060928:c1186745-1186494 [Escherichia coli]
ATGCGTACAATTAGCTACAGCGAAGCGCGTCAGAATTTGTCGGCAACAATGATGAAAGCCGTTGAAGATCATGCCCCGAT
CCTTATTACTCGTCAGAATGGAGAGGCTTGTGTTCTGATGTCACTCGAAGAATACAACTCGCTGGAAGAGACGGCTTATC
TACTGCGCTCCCCCGCTAACGCCCGGAGATTGATGGACTCAATCGATAGCCTGAAATCAGGCAAAGGAACAGAAAAGGAC
ATTATTGAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References