Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tsbAT/-
Location 1496439..1497212 Replicon chromosome
Accession NZ_CP045927
Organism Staphylococcus agnetis strain 1379

Toxin (Protein)


Gene name tsbT Uniprot ID -
Locus tag GJE18_RS07520 Protein ID WP_165804964.1
Coordinates 1496439..1496594 (-) Length 52 a.a.

Antitoxin (Protein)


Gene name tsbA Uniprot ID A0A242VDN1
Locus tag GJE18_RS07525 Protein ID WP_060551399.1
Coordinates 1496613..1497212 (-) Length 200 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GJE18_RS07505 1492789..1494315 - 1527 WP_165886127.1 exopolyphosphatase -
GJE18_RS07510 1494337..1495722 - 1386 WP_060551397.1 class II fumarate hydratase -
GJE18_RS07515 1495879..1496280 - 402 WP_107368905.1 hypothetical protein -
GJE18_RS07520 1496439..1496594 - 156 WP_165804964.1 hypothetical protein Toxin
GJE18_RS07525 1496613..1497212 - 600 WP_060551399.1 hypothetical protein Antitoxin
GJE18_RS07530 1497230..1498399 - 1170 WP_165886128.1 N-acetylglucosamine-6-phosphate deacetylase -
GJE18_RS07535 1498414..1498884 - 471 WP_060551401.1 tRNA (uridine(34)/cytosine(34)/5- carboxymethylaminomethyluridine(34)-2'-O)- methyltransferase TrmL -
GJE18_RS07540 1498887..1500014 - 1128 WP_107368903.1 tRNA epoxyqueuosine(34) reductase QueG -
GJE18_RS07545 1500186..1500908 - 723 WP_107368902.1 amino acid ABC transporter ATP-binding protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Glucosamine-6-phosphate isomerase

(135-197)


Sequences

Toxin        


Download         Length: 52 a.a.        Molecular weight: 6027.40 Da        Isoelectric Point: 3.9813

>T143027 WP_165804964.1 NZ_CP045927:c1496594-1496439 [Staphylococcus agnetis]
MSDEKHIEHENEMVDNFEDLVQLGKEMEQISETNDQDKVNQSHDPNIRSDQ

Download         Length: 156 bp

>T143027 NZ_CP060928:c348352-348245 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCATGATTTTCTGGCACGACCTGGCAGCACCGATCCTGGCGGGAATTATTACCGCAGCGAT
TGTCAGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 200 a.a.        Molecular weight: 22437.36 Da        Isoelectric Point: 5.3398

>AT143027 WP_060551399.1 NZ_CP045927:c1497212-1496613 [Staphylococcus agnetis]
MAMNFKVFKDKDTVAVYAADIIRKQFNNNPTTIAGFHLSEEEAPVFDYLKHNVNDHAVDFSQIHILDYDKQASYFKALGV
PEKQIHEIPEEDEVEKFIEQKAKTKDNKGKLTLQVVSINNKGEFGVPVNNGLKPAREIFVVVTGSDKADVIKKLYEDNGN
TSFIPSSLKTHRMVNVILDEAAAQGLPDDVREYFTSLYA

Download         Length: 600 bp

>AT143027 NZ_CP060928:348399-348465 [Escherichia coli]
TGTCTGGTTTCAAGATTAGCCCCCGTTTTGTTGTCAGGTTTTACCTCTCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A242VDN1

References