Detailed information of TA system TA143001

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/RelE-Phd
• Location: 3063500..3064054
• Replicon: chromosome
• Accession: NZ_CP045920
• Organism: Pseudactinotalea sp. HY158

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: GCE65_RS13390
• Protein ID: WP_153878742.1
• Coordinates: 3063500..3063769 (-)
• Length: 90 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: GCE65_RS13395
• Protein ID: WP_152909984.1
• Coordinates: 3063776..3064054 (-)
• Length: 93 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
GCE65_RS13360	3058540..3060048	-	1509	WP_152910025.1	IMP dehydrogenase	-
GCE65_RS13365	3060169..3060849	+	681	WP_153878738.1	hypothetical protein	-
GCE65_RS13370	3060917..3061213	-	297	WP_153878739.1	co-chaperone GroES	-
GCE65_RS13375	3061441..3062097	+	657	WP_152909986.1	DsbA family oxidoreductase	-
GCE65_RS13380	3062094..3062255	+	162	WP_153878740.1	hypothetical protein	-
GCE65_RS13385	3062260..3063465	+	1206	WP_153878741.1	SAM-dependent methyltransferase	-
GCE65_RS13390	3063500..3063769	-	270	WP_153878742.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
GCE65_RS13395	3063776..3064054	-	279	WP_152909984.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
GCE65_RS13400	3064107..3064589	-	483	WP_153878743.1	GNAT family N-acetyltransferase	-
GCE65_RS13405	3064661..3065806	+	1146	WP_153878744.1	glutamate--cysteine ligase	-
GCE65_RS13410	3065870..3066361	-	492	WP_153878745.1	hypothetical protein	-
GCE65_RS13415	3066469..3066828	-	360	WP_153878746.1	hypothetical protein	-
GCE65_RS13420	3067188..3067616	+	429	WP_153878747.1	hypothetical protein	-
GCE65_RS13425	3067623..3068369	-	747	WP_153878748.1	ABC transporter ATP-binding protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (5-86)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-73)

Sequences

Toxin

Protein

• Length: 90 a.a.
• Molecular weight: 10470.98 Da
• Isoelectric Point: 9.8864

>T143001 WP_153878742.1 NZ_CP045920:c3063769-3063500 [Pseudactinotalea sp. HY158]
MSCEVRLTSAAVRDIERISPRYIDAVLTFIYGPLAENPRRVGKELRREFAGLHSARRGDYRVLYEIRDSEPPEVLVHRID
HRAHVYRPR

Nucleotide

• Length: 270 bp

>T143001 NZ_CP060924:c804784-804410 [Escherichia coli]
ATGAAAACATTACCCGATACACACGTACGGGAGGCATCGAGCTGCCCGTCTCCCGTCACCATCTGGCAGACTCTGCTCTC
CCGACTACTGGGCCAGCATTACGGCCTTACACTGAATGACACACCGTTCGCCGATGAACGTGTGATTGAGCAGCATATTG
AAGCTGGCATTTCACTGTGTGATGCGGTGAATTTTCTCGTGGAAAAATACGCGCTGGTGCGTACCGACCAGCCGGGATTC
AGCACTTGTCCCCGCTCTCAGTTAATAAACAGTATTGATATCCTCCGGGCTCGCCGGGCGACCGGCCTGATGACCCGCGA
CAATTACAGAACGGTAAATAACATTACCCTGGGTAAGCATCCGGAGAAACGATGA

Antitoxin

Protein

• Length: 93 a.a.
• Molecular weight: 10035.17 Da
• Isoelectric Point: 4.6286

>AT143001 WP_152909984.1 NZ_CP045920:c3064054-3063776 [Pseudactinotalea sp. HY158]
METMSISAAKARLNDLVEQAVTTHERVMITRNGSPAAVMVSADEWDAIQETLFWLSRAGVADDVARGRSEDEAGQTFSET
DVRARLGRPARG

Nucleotide

• Length: 279 bp

>AT143001 NZ_CP060924:c805242-804874 [Escherichia coli]
GTGTCAGACAAACTCTCCGGGATAACTCATCCCGACGACAATCACGACCGCCCCTGGTGGGGGCTTCCCTGCACAGTGAG
GCCCTGTTTTGGCGCTCGTCTGGTGCAGGAGGGTAACCGCCTGCATTACCTTGCCGACCACGCCGGTATCAGAGGCCGCT
TCAGCGACGCAGATGCATACCATCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGACATCAGCATACCGTCACGCTGTATGCGAAAGGGCTGACCTGCGAAGCCGACACCCTCGGCTCCTG
TGGTTACGTTTATCTGGCTGTTTATCCGACGCCCGAAACGAAAAAGTAA