Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relE-yefM/YoeB-YefM
Location 877827..878342 Replicon chromosome
Accession NZ_CP045920
Organism Pseudactinotalea sp. HY158

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag GCE65_RS03915 Protein ID WP_153877448.1
Coordinates 878088..878342 (+) Length 85 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID -
Locus tag GCE65_RS03910 Protein ID WP_153877447.1
Coordinates 877827..878087 (+) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GCE65_RS03855 872935..873354 + 420 WP_153877442.1 PIN domain nuclease -
GCE65_RS03860 873564..873797 + 234 WP_152817521.1 toxin-antitoxin system -
GCE65_RS03865 873794..874219 + 426 WP_153877443.1 type II toxin-antitoxin system VapC family toxin -
GCE65_RS03870 874216..874732 + 517 Protein_758 GNAT family N-acetyltransferase -
GCE65_RS03875 874733..875239 - 507 WP_153877444.1 SgcJ/EcaC family oxidoreductase -
GCE65_RS03880 875303..875791 + 489 WP_152817522.1 MarR family transcriptional regulator -
GCE65_RS03885 875929..876210 + 282 WP_153877445.1 type II toxin-antitoxin system RelE/ParE family toxin -
GCE65_RS03890 876225..876524 + 300 WP_152817523.1 HigA family addiction module antidote protein -
GCE65_RS03895 876568..876843 + 276 WP_152817524.1 hypothetical protein -
GCE65_RS03900 876822..877352 + 531 WP_194928821.1 hypothetical protein -
GCE65_RS03905 877426..877722 + 297 WP_153877446.1 type II toxin-antitoxin system RelE/ParE family toxin -
GCE65_RS03910 877827..878087 + 261 WP_153877447.1 type II toxin-antitoxin system prevent-host-death family antitoxin Antitoxin
GCE65_RS03915 878088..878342 + 255 WP_153877448.1 Txe/YoeB family addiction module toxin Toxin
GCE65_RS03920 878439..878768 + 330 WP_152817526.1 nucleotidyltransferase domain-containing protein -
GCE65_RS03925 878765..879100 + 336 WP_153877449.1 DUF86 domain-containing protein -
GCE65_RS16225 879303..879536 + 234 WP_194928898.1 hypothetical protein -
GCE65_RS03935 879816..880184 + 369 WP_153877450.1 carboxymuconolactone decarboxylase family protein -
GCE65_RS03940 880278..880637 + 360 WP_153877451.1 metalloregulator ArsR/SmtB family transcription factor -
GCE65_RS03945 880634..881380 + 747 WP_153877452.1 cation transporter -
GCE65_RS03950 881953..883176 + 1224 WP_153877453.1 MFS transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - - 821332..986994 165662


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-83)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(2-65)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 9810.06 Da        Isoelectric Point: 6.4548

>T142998 WP_153877448.1 NZ_CP045920:878088-878342 [Pseudactinotalea sp. HY158]
VRLVWDESAWEDYKHGQTADRKILKRINTLIDACLREPSSGIGKAEQLKYGAQGSWSRRITDEYRLVYLVDDEDPVILQA
RYHC

Download         Length: 255 bp

>T142998 NZ_CP060921:c64602-64222 [Escherichia coli]
ATGAGGCATATATCACCGGAAGAACTTATTGCGCTTCATGATGCGAATATAAACCGCTACGGCGGCCTGCCGGGAATGTC
AGATCCGGGTAGGGCAGAGGCCATTATCGGGAGAGTTCAGGCCAGAGTTGCCTACGAAGAGATCACCGACCTTTTCGAAG
TCTCCGCCACCTACCTGGTGGCTACAGCGAGAGGGCATATATTCAATGATGCCAATAAGCGTACCGCGCTAAACAGTGCG
CTGCTATTTTTACGCCGTAACGGGGTGCAGGTATTTGATTCACCTGAACTGGCAGACCTTACCGTAGGGGCTGCGACCGG
AGAGATATCTGTATCTTCTGTCGCCGACACGTTACGTAGATTGTATGGTTCCGCGGAGTAG

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9694.80 Da        Isoelectric Point: 4.8485

>AT142998 WP_153877447.1 NZ_CP045920:877827-878087 [Pseudactinotalea sp. HY158]
MSISASEARKTLFPLIERVNADRDAVEIVSRKGNAVLMPADEYAAWQETAYLFRSPANTRRLLDAYDRARGGRVEVHDLD
RADDEA

Download         Length: 261 bp

>AT142998 NZ_CP060921:c64823-64602 [Escherichia coli]
ATGCAATCCATTAACTTCCGTACCGCGCGCGGCAACCTTTCTGAAGTGCTCAACAATGTTGAAGCCGGGGAAGAGGTTGA
AATCACCCGCAGAGGCCGTGAGCCAGCAGTAATTGTCAGCAAGGCTACTTTCGAAGCCTACAAAAAAGCGGCGCTGGATG
CTGAATTTGCATCCCTGTTTGACACCCTGGACTCCACCAACAAGGAACTGGTTAACCGATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References