Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-StbC
Location 873564..874219 Replicon chromosome
Accession NZ_CP045920
Organism Pseudactinotalea sp. HY158

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag GCE65_RS03865 Protein ID WP_153877443.1
Coordinates 873794..874219 (+) Length 142 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag GCE65_RS03860 Protein ID WP_152817521.1
Coordinates 873564..873797 (+) Length 78 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GCE65_RS03830 869179..869718 + 540 WP_153877437.1 DUF1877 domain-containing protein -
GCE65_RS03835 870038..871114 + 1077 WP_153877438.1 redox-regulated ATPase YchF -
GCE65_RS03840 871199..872056 - 858 WP_153877439.1 alpha/beta hydrolase -
GCE65_RS03845 872112..872501 + 390 WP_194928820.1 MerR family transcriptional regulator -
GCE65_RS03850 872723..872944 + 222 WP_153877441.1 hypothetical protein -
GCE65_RS03855 872935..873354 + 420 WP_153877442.1 PIN domain nuclease -
GCE65_RS03860 873564..873797 + 234 WP_152817521.1 toxin-antitoxin system Antitoxin
GCE65_RS03865 873794..874219 + 426 WP_153877443.1 type II toxin-antitoxin system VapC family toxin Toxin
GCE65_RS03870 874216..874732 + 517 Protein_758 GNAT family N-acetyltransferase -
GCE65_RS03875 874733..875239 - 507 WP_153877444.1 SgcJ/EcaC family oxidoreductase -
GCE65_RS03880 875303..875791 + 489 WP_152817522.1 MarR family transcriptional regulator -
GCE65_RS03885 875929..876210 + 282 WP_153877445.1 type II toxin-antitoxin system RelE/ParE family toxin -
GCE65_RS03890 876225..876524 + 300 WP_152817523.1 HigA family addiction module antidote protein -
GCE65_RS03895 876568..876843 + 276 WP_152817524.1 hypothetical protein -
GCE65_RS03900 876822..877352 + 531 WP_194928821.1 hypothetical protein -
GCE65_RS03905 877426..877722 + 297 WP_153877446.1 type II toxin-antitoxin system RelE/ParE family toxin -
GCE65_RS03910 877827..878087 + 261 WP_153877447.1 type II toxin-antitoxin system prevent-host-death family antitoxin -
GCE65_RS03915 878088..878342 + 255 WP_153877448.1 Txe/YoeB family addiction module toxin -
GCE65_RS03920 878439..878768 + 330 WP_152817526.1 nucleotidyltransferase domain-containing protein -
GCE65_RS03925 878765..879100 + 336 WP_153877449.1 DUF86 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - - 821332..986994 165662


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-122)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 142 a.a.        Molecular weight: 14891.92 Da        Isoelectric Point: 5.1782

>T142996 WP_153877443.1 NZ_CP045920:873794-874219 [Pseudactinotalea sp. HY158]
VIVLDTNVISEVFRPSPEARVVGWLASLTGDVSITSVTLAELLAGVRRLADGRRKTELTKHIESALGPYRGSRSVLPFDE
AAAECHADVLLAREAVGVPISTADAQIAAICLAHDATCATRNVKDFANTGIDLINPSRTDG

Download         Length: 426 bp

>T142996 NZ_CP060919:c4588942-4588592 [Escherichia coli]
ATGGTAAAGAAAAGTGAATTTGAACGGGGAGACATTGTGCTGGTTGGCTTTGATCCAGCAAGCGGCCATGAACAGCAAGG
TGCTGGTCGACCTGCGCTTGTGCTCTCCGTTCAAGCCTTTAATCAACTGGGAATGACGCTGGTGGCCCCCATTACGCAGG
GCGGAAATTTTGCCCGTTATGCCGGATTTAGCGTTCCTTTACATTGCGAAGAAGGCGATGTGCACGGCGTGGTGCTGGTG
AATCAGGTGCGGATGATGGATCTACGCGCCCGGCTGGCAAAGCGTATTGGTCTGGCTGCGGATGAGGTGGTGGAAGAGGC
GTTATTACGCTTGCAGGCGGTGGTGGAATAA

Antitoxin


Download         Length: 78 a.a.        Molecular weight: 8291.51 Da        Isoelectric Point: 6.4613

>AT142996 WP_152817521.1 NZ_CP045920:873564-873797 [Pseudactinotalea sp. HY158]
MSSIIVRGLDDAVKQQLATQAKEHGRSMEAEVRDILTKAARRPHIGMALLAAAQEVGGVQELPIPVRDDVARSVDFG

Download         Length: 234 bp

>AT142996 NZ_CP060919:c4589187-4588936 [Escherichia coli]
ATGCGTATTACCATAAAAAGATGGGGGAACAGTGCAGGTATGGTCATTCCCAATATCGTAATGAAAGAACTTAACTTACA
GCCGGGGCAGAGCGTGGAAGCGCAGGTGAGCAACAACCAACTGATTCTGACACCCATCTCCAGGCGCTACTCGCTTGATG
AACTGCTGGCACAGTGTGACATGAACGCCGCGGAACTTAGCGAGCAGGATGTCTGGGGTAAATCCACCCCTGCGGGTGAC
GAAATATGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References