Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/LOTUS_5_Limkain_b1-PHD
Location 188780..189465 Replicon chromosome
Accession NZ_CP045920
Organism Pseudactinotalea sp. HY158

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag GCE65_RS00890 Protein ID WP_194928761.1
Coordinates 189058..189465 (+) Length 136 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag GCE65_RS00885 Protein ID WP_152817882.1
Coordinates 188780..189040 (+) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GCE65_RS00860 184077..184391 + 315 WP_152817887.1 QacE family quaternary ammonium compound efflux SMR transporter -
GCE65_RS00865 184528..185145 - 618 WP_153877049.1 MerR family transcriptional regulator -
GCE65_RS00870 185216..185629 + 414 WP_153877050.1 hypothetical protein -
GCE65_RS00875 185949..187385 - 1437 WP_152817884.1 aspartate ammonia-lyase -
GCE65_RS00880 187497..188588 - 1092 WP_153877051.1 enoyl-CoA hydratase/isomerase family protein -
GCE65_RS00885 188780..189040 + 261 WP_152817882.1 type II toxin-antitoxin system prevent-host-death family antitoxin Antitoxin
GCE65_RS00890 189058..189465 + 408 WP_194928761.1 PIN domain-containing protein Toxin
GCE65_RS00895 189737..190690 + 954 WP_152817881.1 methylenetetrahydrofolate reductase -
GCE65_RS00900 190787..193138 + 2352 WP_153877052.1 5-methyltetrahydropteroyltriglutamate-- homocysteine S-methyltransferase -
GCE65_RS00905 193440..194081 - 642 WP_153877053.1 YigZ family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(9-121)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-53)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 14497.51 Da        Isoelectric Point: 5.7628

>T142993 WP_194928761.1 NZ_CP045920:189058-189465 [Pseudactinotalea sp. HY158]
VPDRDERGLLDTSVLIAHESGRRLEASSLPEEGYVSVITLAELEAGVLAAGDQTIRSRRLATLTRVSALVALPIDAAAAA
HWARMRVRLAESGRRVNVNDLWIAAVARANGLAVYTRDADYGPLAELGELRVVTV

Download         Length: 408 bp

>T142993 NZ_CP060919:4042185-4042463 [Escherichia coli]
ATGATTCAAAGGGATATTGAATACTCGGGACAATTTTCAAAGGATGTAAAAGTTGCACAAAAGCGTCATAAGGATATGAA
TAAATTGAAATATCTTATGACGCTTCTTATCAATAATACTTTACCGCTTCCAGCTGTTTATAAAGACCACCCGCTGCAAG
GTTCATGGAAAGGTTATCGCGATGCTCATGTCGAACCGGACTGGATCCTGATTTACAAACTTACCGATAAACTTTTACGA
TTTGAGAGAACTGGAACTCACGCGGCGCTCTTTGGGTAA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9187.32 Da        Isoelectric Point: 4.7628

>AT142993 WP_152817882.1 NZ_CP045920:188780-189040 [Pseudactinotalea sp. HY158]
MANVASRDLRNHTGDVLRRVTEGERITVTQHGRPVAEISPAAPTRPAFFSRAELAELLLAGQADPALRDELSILAGETTD
DLGPIA

Download         Length: 261 bp

>AT142993 NZ_CP060919:4041922-4042182 [Escherichia coli]
ATGGCTGCTAACGCATTTGTTCGCGCCCGAATCGATGAAGATCTGAAGAATCAGGCGGCGGACGTACTGGCCGGGATGGG
GCTGACCATCTCTGACCTGGTTCGCATAACCCTCACAAAGGTCGCGCGTGAAAAGGCATTGCCGTTTGATTTACGCGAGC
CTAATCAATTAACCATTCAATCAATCAAAAACAGCGAAGCTGGCGTTGATGTTCATAAGGCCAAAGACGCCGATGATTTA
TTTGATAAATTAGGAATTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References