Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 136343..137034 Replicon chromosome
Accession NZ_CP045920
Organism Pseudactinotalea sp. HY158

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag GCE65_RS00640 Protein ID WP_153877016.1
Coordinates 136603..137034 (+) Length 144 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag GCE65_RS16125 Protein ID WP_194928897.1
Coordinates 136343..136603 (+) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GCE65_RS00610 131607..132842 + 1236 WP_153877011.1 serine/threonine protein kinase -
GCE65_RS00615 132940..133566 + 627 WP_153877012.1 hypothetical protein -
GCE65_RS00620 133572..134207 + 636 WP_153877013.1 OmpA family protein -
GCE65_RS16120 134875..135042 - 168 WP_194928757.1 transposase -
GCE65_RS00630 135629..136108 - 480 WP_153877015.1 hypothetical protein -
GCE65_RS16125 136343..136603 + 261 WP_194928897.1 CopG family transcriptional regulator Antitoxin
GCE65_RS00640 136603..137034 + 432 WP_153877016.1 PIN domain-containing protein Toxin
GCE65_RS00645 137078..139099 - 2022 WP_153877017.1 5'-nucleotidase C-terminal domain-containing protein -
GCE65_RS00650 139137..140321 + 1185 WP_153879101.1 tellurite resistance/C4-dicarboxylate transporter family protein -
GCE65_RS00655 140401..141792 + 1392 WP_153877018.1 mycothione reductase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain toxin

(1-142)

Antitoxin

Bacterial antitoxin of type II TA system, VapB

(1-44)


Sequences

Toxin        


Download         Length: 144 a.a.        Molecular weight: 15946.32 Da        Isoelectric Point: 8.0443

>T142992 WP_153877016.1 NZ_CP045920:136603-137034 [Pseudactinotalea sp. HY158]
MLFPDVNVVVYAFRPSDSERAAAVRTWLLDRLDRGEQMGVSELVLSAFVRIATNGRIFNEPATPASALAFADSLLAHPRV
SVVRGRDRHWPFFRELLLQNKLRGNDVPDAYLAALCLEAGATMATTDRGFRRFDGLRMVDPLA

Download         Length: 432 bp

>T142992 NZ_CP060919:3805682-3806224 [Escherichia coli]
ATGGTCGACAAGCATGAAGAGATTACTCTGCCCATAGTCCTCTCCTGTAATTATCAGTCTGATATTACTTATCCTGGGCA
AAAACAGTTTGATTGCGGTAACCCTGTTATCGATAAATTTGTACGCGCATCGCTAAAGAAAAGTGTGCGTAATAGCGACT
GTGCGGCTAAAGCACTTATTGACAGACAAAGTGGTGAACTGATCGGCATCTGTACTTTTACGGCATATTCGCTGGAAAAA
CAACGCGTTTCTGGCGTCCTTCAGGGTTCACAACCTTCAGAAATTGGTGTTGTCAGATTAGTCATGTTGGGGGTAGCACG
GAAGTATCAAAAGCGGGGCTTTGGTCAGGACCTACTATGTGATTTTTTTGAACATGTAAAAATAATTCACCAGGCATTAC
CAATTAAAGGGGTTTATCTTGATGCTGACCCTGCCGCCATTAATTTTTATGCTCGTCTCGGCTTTGTTCAGCTTTCAGCG
ACACCAAATGCTTTTGGTGCTGTACCTATGTTTTTGGCGATTCAGCATATTCTCGCGGCTTAG

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9774.97 Da        Isoelectric Point: 4.3813

>AT142992 WP_194928897.1 NZ_CP045920:136343-136603 [Pseudactinotalea sp. HY158]
MRTTVNIDEYLLAEARLLAVRSRRPMGSILEEALRRYLNERGREDEGQPAELPEFKPTDPGLRPGVDLDDREQIAELLGE
NDAGIR

Download         Length: 261 bp

>AT142992 NZ_CP060919:3805387-3805698 [Escherichia coli]
ATGCCTGGAAAAACAGCCACTCTACCCGATGTCGATAAAACGCTGAAAAATGCGCGGGTCGAACTCAAAACTAGTCCCGA
CGCCAAAAACAAACTTCGTGAAGCTGCGCAAGCCGTTGGGGTAGATTTAAGCGCTTTTATTTTGAGCGCTGCTATGGAAC
GCGCCGAAAGTGTGCTTGATAACCAACGTCGCCGTGAGCTTTCGAATCAAAGCTGGGAACTGATGAACCAACTCATCGCT
GAACCTGCTCAACCGACGCTCGCCCTCAAGGCGTTAATGAAAAGGAAAAACAGCGATGGTCGACAAGCATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References