Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE-RHH
Location 207555..208102 Replicon plasmid pCF39S
Accession NZ_CP045917
Organism Pseudomonas aeruginosa strain CF39S

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag GIY05_RS32675 Protein ID WP_085286979.1
Coordinates 207827..208102 (+) Length 92 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag GIY05_RS32670 Protein ID WP_085286980.1
Coordinates 207555..207827 (+) Length 91 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GIY05_RS32650 202988..205954 - 2967 WP_001138014.1 Tn3-like element TnAs1 family transposase -
GIY05_RS32655 205958..206518 - 561 WP_001161490.1 recombinase family protein -
GIY05_RS32665 206796..207533 + 738 WP_141989053.1 DUF2807 domain-containing protein -
GIY05_RS32670 207555..207827 + 273 WP_085286980.1 ribbon-helix-helix domain-containing protein Antitoxin
GIY05_RS32675 207827..208102 + 276 WP_085286979.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
GIY05_RS32680 208401..210785 - 2385 WP_141989052.1 penicillin acylase family protein -
GIY05_RS32685 210919..211950 + 1032 WP_141989050.1 AraC family transcriptional regulator -
GIY05_RS32690 211947..212057 - 111 Protein_202 thiol-disulfide isomerase -
GIY05_RS32695 212092..212463 - 372 WP_023294894.1 hypothetical protein -
GIY05_RS32700 212460..212786 - 327 WP_000091614.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid aph(6)-Id / aph(3'')-Ib / sul1 / tet(G) / floR - 1..468631 468631


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-90)

Antitoxin

Ribbon-helix-helix protein, CopG

(10-47)


Sequences

Toxin        


Download         Length: 92 a.a.        Molecular weight: 10795.34 Da        Isoelectric Point: 7.0128

>T142990 WP_085286979.1 NZ_CP045917:207827-208102 [Pseudomonas aeruginosa]
MELKWTSKALSDITRLYEFLATVNQPAAARTVQQLTAAPTTLLTNPRIGERLEEFEPRDVRRIQIGQYEMRYEIVDSTIY
LLRLWHTREDR

Download         Length: 276 bp

>T142990 NZ_CP060919:3016510-3016617 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCATGATTTTCTGGCACGACCTGGCAGCACCGATCCTGGCGGGAATTATTACCGCAGCGAT
TGTCGGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 91 a.a.        Molecular weight: 10091.37 Da        Isoelectric Point: 5.6994

>AT142990 WP_085286980.1 NZ_CP045917:207555-207827 [Pseudomonas aeruginosa]
MATTAKTRSVTAHVPEQLAQKVDLMAERLERSKNWIVKQALSAWIDQEEERSRLTREALADVDAGRVIDHQAVQAWADSL
SSDTPLPVPR

Download         Length: 273 bp

>AT142990 NZ_CP060919:c3016460-3016397 [Escherichia coli]
TCTGGTTCAAGATTAGCCCCCGTTCTGTTGTCAGGTTAAACCTCTCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References