Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | slvAT/RES(toxin) |
Location | 151109..152025 | Replicon | plasmid pCF39S |
Accession | NZ_CP045917 | ||
Organism | Pseudomonas aeruginosa strain CF39S |
Toxin (Protein)
Gene name | slvT | Uniprot ID | A0A2L1KI32 |
Locus tag | GIY05_RS32420 | Protein ID | WP_019437783.1 |
Coordinates | 151109..151633 (-) | Length | 175 a.a. |
Antitoxin (Protein)
Gene name | slvA | Uniprot ID | A0A2L1KH13 |
Locus tag | GIY05_RS32425 | Protein ID | WP_019437782.1 |
Coordinates | 151630..152025 (-) | Length | 132 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
GIY05_RS32400 | 146430..147575 | + | 1146 | WP_021263240.1 | glycerate kinase | - |
GIY05_RS32405 | 147995..148186 | - | 192 | WP_019437785.1 | hypothetical protein | - |
GIY05_RS32410 | 148561..149616 | + | 1056 | WP_109392701.1 | prepilin-type N-terminal cleavage/methylation domain-containing protein | - |
GIY05_RS32415 | 149813..151063 | + | 1251 | WP_019437784.1 | TerD family protein | - |
GIY05_RS32420 | 151109..151633 | - | 525 | WP_019437783.1 | RES family NAD+ phosphorylase | Toxin |
GIY05_RS32425 | 151630..152025 | - | 396 | WP_019437782.1 | hypothetical protein | Antitoxin |
GIY05_RS32430 | 152609..154528 | - | 1920 | WP_021263737.1 | hypothetical protein | - |
GIY05_RS32435 | 154692..154946 | + | 255 | WP_021263738.1 | hypothetical protein | - |
GIY05_RS32440 | 155840..156364 | + | 525 | WP_010794447.1 | hypothetical protein | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|---|---|---|---|---|---|---|
- | inside | Non-Mobilizable plasmid | aph(6)-Id / aph(3'')-Ib / sul1 / tet(G) / floR | - | 1..468631 | 468631 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 175 a.a. Molecular weight: 19052.57 Da Isoelectric Point: 4.5535
>T142989 WP_019437783.1 NZ_CP045917:c151633-151109 [Pseudomonas aeruginosa]
MKIIGVQDLPCYRMHTPKWSVAPTSGAGAATQGGRVNRKGLEALYLSLESATAIAEFQQASAFLPPGLLISYSLSLDRVI
DFTGGYNDTWAPIWQDFFCDWRKIRFNDGVEPPSWIIGDLAIEADCAGILFESVANPGGRNLVLFTDQLPVHGNIVVNDP
RGDLPTDQSSWTRP
MKIIGVQDLPCYRMHTPKWSVAPTSGAGAATQGGRVNRKGLEALYLSLESATAIAEFQQASAFLPPGLLISYSLSLDRVI
DFTGGYNDTWAPIWQDFFCDWRKIRFNDGVEPPSWIIGDLAIEADCAGILFESVANPGGRNLVLFTDQLPVHGNIVVNDP
RGDLPTDQSSWTRP
Download Length: 525 bp
>T142989 NZ_CP060919:3015975-3016082 [Escherichia coli]
ATGACGCTCGCGAAGTTTGCCATGATTTTCTGGCACGACCTGGCAGCACCGATCCTGGCGGGGATTATTACCGCAGCGAT
TGTCGGCTGGTGGCGTAACCGGAAGTAA
ATGACGCTCGCGAAGTTTGCCATGATTTTCTGGCACGACCTGGCAGCACCGATCCTGGCGGGGATTATTACCGCAGCGAT
TGTCGGCTGGTGGCGTAACCGGAAGTAA
Antitoxin
Download Length: 132 a.a. Molecular weight: 14753.87 Da Isoelectric Point: 7.2048
>AT142989 WP_019437782.1 NZ_CP045917:c152025-151630 [Pseudomonas aeruginosa]
MASKAVLELRPTNFAGLMDALKEVNRVMFSPERFLKVFSMDQQTLALRAHVHRNTVRNAPESEKVQAYIRDSVKVLRAVT
DMGTDVTNAIFWFKNEPLSTFGYKTAEEVVSEGKTEQLIAFLQSWEAGAQG
MASKAVLELRPTNFAGLMDALKEVNRVMFSPERFLKVFSMDQQTLALRAHVHRNTVRNAPESEKVQAYIRDSVKVLRAVT
DMGTDVTNAIFWFKNEPLSTFGYKTAEEVVSEGKTEQLIAFLQSWEAGAQG
Download Length: 396 bp
>AT142989 NZ_CP060919:c3015922-3015861 [Escherichia coli]
TGGTTCAAGATTAGCCCCCGTTCTGTTGTCAGGTTTTACCTCTCAACGTGCGGGGGTTTTCT
TGGTTCAAGATTAGCCCCCGTTCTGTTGTCAGGTTTTACCTCTCAACGTGCGGGGGTTTTCT
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Structures
Toxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A2L1KI32 |
Antitoxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A2L1KH13 |