Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) slvAT/RES(toxin)
Location 151109..152025 Replicon plasmid pCF39S
Accession NZ_CP045917
Organism Pseudomonas aeruginosa strain CF39S

Toxin (Protein)


Gene name slvT Uniprot ID A0A2L1KI32
Locus tag GIY05_RS32420 Protein ID WP_019437783.1
Coordinates 151109..151633 (-) Length 175 a.a.

Antitoxin (Protein)


Gene name slvA Uniprot ID A0A2L1KH13
Locus tag GIY05_RS32425 Protein ID WP_019437782.1
Coordinates 151630..152025 (-) Length 132 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GIY05_RS32400 146430..147575 + 1146 WP_021263240.1 glycerate kinase -
GIY05_RS32405 147995..148186 - 192 WP_019437785.1 hypothetical protein -
GIY05_RS32410 148561..149616 + 1056 WP_109392701.1 prepilin-type N-terminal cleavage/methylation domain-containing protein -
GIY05_RS32415 149813..151063 + 1251 WP_019437784.1 TerD family protein -
GIY05_RS32420 151109..151633 - 525 WP_019437783.1 RES family NAD+ phosphorylase Toxin
GIY05_RS32425 151630..152025 - 396 WP_019437782.1 hypothetical protein Antitoxin
GIY05_RS32430 152609..154528 - 1920 WP_021263737.1 hypothetical protein -
GIY05_RS32435 154692..154946 + 255 WP_021263738.1 hypothetical protein -
GIY05_RS32440 155840..156364 + 525 WP_010794447.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid aph(6)-Id / aph(3'')-Ib / sul1 / tet(G) / floR - 1..468631 468631


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

RES domain

(10-167)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 175 a.a.        Molecular weight: 19052.57 Da        Isoelectric Point: 4.5535

>T142989 WP_019437783.1 NZ_CP045917:c151633-151109 [Pseudomonas aeruginosa]
MKIIGVQDLPCYRMHTPKWSVAPTSGAGAATQGGRVNRKGLEALYLSLESATAIAEFQQASAFLPPGLLISYSLSLDRVI
DFTGGYNDTWAPIWQDFFCDWRKIRFNDGVEPPSWIIGDLAIEADCAGILFESVANPGGRNLVLFTDQLPVHGNIVVNDP
RGDLPTDQSSWTRP

Download         Length: 525 bp

>T142989 NZ_CP060919:3015975-3016082 [Escherichia coli]
ATGACGCTCGCGAAGTTTGCCATGATTTTCTGGCACGACCTGGCAGCACCGATCCTGGCGGGGATTATTACCGCAGCGAT
TGTCGGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 132 a.a.        Molecular weight: 14753.87 Da        Isoelectric Point: 7.2048

>AT142989 WP_019437782.1 NZ_CP045917:c152025-151630 [Pseudomonas aeruginosa]
MASKAVLELRPTNFAGLMDALKEVNRVMFSPERFLKVFSMDQQTLALRAHVHRNTVRNAPESEKVQAYIRDSVKVLRAVT
DMGTDVTNAIFWFKNEPLSTFGYKTAEEVVSEGKTEQLIAFLQSWEAGAQG

Download         Length: 396 bp

>AT142989 NZ_CP060919:c3015922-3015861 [Escherichia coli]
TGGTTCAAGATTAGCCCCCGTTCTGTTGTCAGGTTTTACCTCTCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2L1KI32

Antitoxin

Source ID Structure
AlphaFold DB A0A2L1KH13

References