Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/RHH(antitoxin)
Location 148015..148520 Replicon chromosome
Accession NZ_CP045916
Organism Pseudomonas aeruginosa strain CF39S

Toxin (Protein)


Gene name parE Uniprot ID V6A7K8
Locus tag GIY05_RS00655 Protein ID WP_003083773.1
Coordinates 148015..148296 (-) Length 94 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID A0A1C7BDS9
Locus tag GIY05_RS00660 Protein ID WP_003083775.1
Coordinates 148293..148520 (-) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GIY05_RS00630 143266..144615 + 1350 WP_003142411.1 C4-dicarboxylate transporter DctA -
GIY05_RS00635 144664..145350 + 687 WP_003083762.1 FadR family transcriptional regulator -
GIY05_RS00640 145451..146185 + 735 WP_003101224.1 GntR family transcriptional regulator -
GIY05_RS00645 146389..146775 + 387 WP_014602345.1 aegerolysin family protein -
GIY05_RS00650 146807..147715 - 909 WP_003083769.1 LysR family transcriptional regulator -
GIY05_RS00655 148015..148296 - 282 WP_003083773.1 type II toxin-antitoxin system toxin ParE Toxin
GIY05_RS00660 148293..148520 - 228 WP_003083775.1 CopG family ribbon-helix-helix protein Antitoxin
GIY05_RS00665 148696..149316 - 621 WP_003101226.1 hypothetical protein -
GIY05_RS00670 149417..149917 + 501 WP_003101228.1 LEA type 2 family protein -
GIY05_RS00675 149990..150331 + 342 WP_003101229.1 alkylphosphonate utilization protein -
GIY05_RS00680 150413..151840 - 1428 WP_003083784.1 GABA permease -
GIY05_RS00685 152009..153502 - 1494 WP_003101230.1 CoA-acylating methylmalonate-semialdehyde dehydrogenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-87)

Antitoxin

Ribbon-helix-helix protein, CopG

(5-42)


Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 10462.19 Da        Isoelectric Point: 10.0435

>T142983 WP_003083773.1 NZ_CP045916:c148296-148015 [Pseudomonas aeruginosa]
MSLKWTRKAAADLDAIYDHYVVLIGPEKALKAVQDIVEQVKPLQQVANQGAGRPSEVPGVRTLTLERWPFSAPFRVKGKE
IQILRIDRVEITP

Download         Length: 282 bp

>T142983 NZ_CP060919:2161457-2161708 [Escherichia coli]
ATGCGTACAATTAGCTACAGCGAAGCGCGTCAGAATTTGTCGGCAACAATGATGAAAGCCGTTGAAGATCATGCCCCGAT
CCTCATTACTCGTCAGAATGGAGAGGCTTGTGTTCTGATGTCACTCGAAGAATACAACTCGCTGGAAGAGACGGCTTATC
TACTGCGTTCCCCCGCTAACGCCCGGAGATTGATGGACTCAATCGATAGCCTGAAATCAGGCAAAGGAACGGAAAAGGAC
ATTATTGAGTGA

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8556.58 Da        Isoelectric Point: 5.5740

>AT142983 WP_003083775.1 NZ_CP045916:c148520-148293 [Pseudomonas aeruginosa]
MSTVVSFRADDALVAALDELARATHRDRPYHLRQALAQYLERQQWQVAAIDEGLADANAGRLLEHTEIEKRWGLQ

Download         Length: 228 bp

>AT142983 NZ_CP060919:2161705-2161959 [Escherichia coli]
GTGAAACTAATCTGGTCTGAGGAATCATGGGATGATTATCTGTACTGGCAGGAAACAGATAAGCGAATTGTTAAAAAGAT
CAATGAACTTATCAAAGATACCCGCAGAACACCATTTGAAGGTAAGGGGAAACCAGAACCCCTGAAACATAATTTGTCAG
GTTTCTGGTCCCGACGCATTACAGAGGAGCACCGTCTGGTATACGCGGTTACTGATGATTCACTGCTCATTGCAGCATGT
CGTTATCATTATTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6XRW

Antitoxin

Source ID Structure
AlphaFold DB A0A1C7BDS9

References