Detailed information of TA system TA142980

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/-
• Location: 3784807..3785444
• Replicon: chromosome
• Accession: NZ_CP045913
• Organism: Serratia proteamaculans strain 336X

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: -
• Locus tag: GHV41_RS18015
• Protein ID: WP_153859492.1
• Coordinates: 3785169..3785444 (-)
• Length: 92 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: -
• Locus tag: GHV41_RS18010
• Protein ID: WP_153859491.1
• Coordinates: 3784807..3785172 (-)
• Length: 122 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
GHV41_RS17990	3780723..3781772	+	1050	WP_153859487.1	phage portal protein	-
GHV41_RS17995	3781775..3783595	+	1821	WP_153859488.1	hypothetical protein	-
GHV41_RS18000	3783606..3784433	+	828	WP_153859489.1	hypothetical protein	-
GHV41_RS18005	3784511..3784780	+	270	WP_153859490.1	ogr/Delta-like zinc finger family protein	-
GHV41_RS18010	3784807..3785172	-	366	WP_153859491.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
GHV41_RS18015	3785169..3785444	-	276	WP_153859492.1	type II toxin-antitoxin system HicA family toxin	Toxin
GHV41_RS18020	3785501..3786208	-	708	WP_153859493.1	DNA adenine methylase	-
GHV41_RS18025	3786332..3786661	-	330	WP_153859494.1	hypothetical protein	-
GHV41_RS18030	3786714..3788698	-	1985	Protein_3508	replication endonuclease	-
GHV41_RS18035	3789010..3789447	-	438	Protein_3509	hypothetical protein	-
GHV41_RS18040	3789444..3790253	-	810	WP_153859495.1	Dam family site-specific DNA-(adenine-N6)-methyltransferase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	3759436..3794936	35500

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (30-79)

Antitoxin

• Uncharacterised protein family HicB (62-114)

Sequences

Toxin

Protein

• Length: 92 a.a.
• Molecular weight: 10028.57 Da
• Isoelectric Point: 10.4888

>T142980 WP_153859492.1 NZ_CP045913:c3785444-3785169 [Serratia proteamaculans]
MKEQVSALRKRQTSTLEQIFKTPVLSGIKWSDVESLIKALGGEVKEGRGSRCKFLLGGSIANFHRPHPSPDTDKGAVVNL
RDWLESIGVKP

Nucleotide

• Length: 276 bp

>T142980 NZ_CP045913:c3785444-3785169 [Serratia proteamaculans]
ATGAAAGAACAGGTTTCAGCGTTAAGGAAGAGACAAACAAGCACTTTAGAACAGATATTTAAAACACCTGTTCTATCCGG
GATTAAATGGTCAGATGTGGAATCACTGATTAAGGCGCTAGGCGGGGAAGTTAAAGAGGGCCGCGGTTCACGATGCAAGT
TCCTGCTTGGTGGCAGTATCGCCAACTTTCACCGCCCCCACCCATCGCCCGACACGGATAAAGGCGCGGTGGTCAACCTC
CGCGACTGGCTGGAAAGCATAGGAGTTAAGCCATGA

Antitoxin

Protein

• Length: 122 a.a.
• Molecular weight: 13324.01 Da
• Isoelectric Point: 4.5792

>AT142980 WP_153859491.1 NZ_CP045913:c3785172-3784807 [Serratia proteamaculans]
MTKTAAATPNTMEIAGQPAIISYVPELGAFRGKFLGLTGYCDFVSDSIQGLHAEGEISLREYLDDCSAASIEPYARQEKI
KTFTLRYPESFGERLNQAAAENEVSVNAFIVETLNERMKHA

Nucleotide

• Length: 366 bp

>AT142980 NZ_CP045913:c3785172-3784807 [Serratia proteamaculans]
ATGACGAAGACAGCAGCAGCAACACCGAACACCATGGAGATCGCCGGGCAACCGGCGATAATCAGTTACGTTCCCGAACT
CGGCGCGTTCCGCGGTAAATTTCTCGGTCTGACGGGTTACTGCGACTTTGTTTCTGACAGCATCCAGGGACTACACGCCG
AGGGTGAGATCTCTTTGCGCGAGTACCTGGACGATTGCAGCGCTGCCAGCATCGAGCCATATGCACGCCAGGAGAAAATC
AAGACGTTCACCCTGCGTTACCCGGAATCTTTCGGGGAACGGCTGAACCAGGCGGCCGCAGAAAATGAAGTTTCTGTGAA
TGCCTTCATTGTTGAAACGTTAAACGAACGCATGAAGCATGCATAA