Detailed information of TA system TA142979

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC-VagC
• Location: 3687087..3687739
• Replicon: chromosome
• Accession: NZ_CP045913
• Organism: Serratia proteamaculans strain 336X

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: GHV41_RS17545
• Protein ID: WP_153859422.1
• Coordinates: 3687353..3687739 (+)
• Length: 129 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: -
• Locus tag: GHV41_RS17540
• Protein ID: WP_153859421.1
• Coordinates: 3687087..3687350 (+)
• Length: 88 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
GHV41_RS17525	3683459..3684376	-	918	WP_153859418.1	lipid kinase YegS	-
GHV41_RS17530	3684865..3686217	-	1353	WP_153859419.1	tRNA 5-hydroxyuridine modification protein YegQ	-
GHV41_RS17535	3686396..3686734	-	339	WP_153859420.1	YegP family protein	-
GHV41_RS17540	3687087..3687350	+	264	WP_153859421.1	AbrB/MazE/SpoVT family DNA-binding domain-containing protein	Antitoxin
GHV41_RS17545	3687353..3687739	+	387	WP_153859422.1	type II toxin-antitoxin system VapC family toxin	Toxin
GHV41_RS17550	3687736..3688452	-	717	WP_153860936.1	two-component system response regulator BaeR	-
GHV41_RS17555	3688452..3689834	-	1383	WP_153859423.1	two-component system sensor histidine kinase BaeS	-
GHV41_RS17560	3689831..3691261	-	1431	WP_153859424.1	MFS transporter	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (2-119)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 129 a.a.
• Molecular weight: 13976.16 Da
• Isoelectric Point: 6.7001

>T142979 WP_153859422.1 NZ_CP045913:3687353-3687739 [Serratia proteamaculans]
MYMFDTNTVSQLFRRHPRLLGLMEKIPPSSVCISSITEAELLYGVAKRQSLTLKATVAAFLDSVTVYAWDSEAAHCYGTM
RAEMTKNGRVMGALDQLIAAHAQSCGATIVTNDKAFAMVPGLAVEDWT

Nucleotide

• Length: 387 bp

>T142979 NZ_CP060919:c1041907-1041530 [Escherichia coli]
ATGAAAACATTACCTGACACACACGTACGGGAGGCATCGCGCTGCCCGTCTCCCGTCACCATCTGGCAGACACTGCTCAC
CCGACTGTTGGACCAGCATTACGGCCTCACACTGAATGACACACCGTTCGCTGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGCGATGCGGTGAACTTTCTCGTTGAAAAATACGCACTGGTACGTACCGACCAGCCAGGATTC
AGCGCCTGTACCCGTTCTCAGTTAATAAACAGTATTGATATCCTCCGGGCCCGCCGGGCAACCGGCCTGATGGCCCGCGA
CAATTACAGAACGGTAAATAACATTACCCTGGGTAAACATCCGGGGGCGAAACAATGA

Antitoxin

Protein

• Length: 88 a.a.
• Molecular weight: 10172.50 Da
• Isoelectric Point: 5.1351

>AT142979 WP_153859421.1 NZ_CP045913:3687087-3687350 [Serratia proteamaculans]
MERIAKLFKNGRNQAVRLPVEFEFDTDRVYIRRDREGNVILSKYPAKPDSWAPLLQMIAQTQVPQDFLTTEDRQQGMTTR
DPFAGEE

Nucleotide

• Length: 264 bp

>AT142979 NZ_CP060919:c1042328-1041954 [Escherichia coli]
GTGTCAGACACTCTCCCCGGGACAACGCATCCCGACGATAACAACGACCGCCCCTGGTGGGGGCTACCCTGCACCGTGAC
GCCCTGTTTTGGGGCACGTCTGGTGCAGGAGGGTAACCGGTTGCATTACCTTGCAGACCGCGCCGGTATCAGAGGCCGGT
TCAGCGACGCGGATGCGTACCATCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGCCATCAGCATACCGTCACGCTGTATGCAAAAGGGCTGACCTGCAAAGCCGATACCCTCAGCAGTTG
TGGTTACGTTTATATGGCTGTTTATCCGACACTGGCACCCGCAACCACCTCATAA