Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 3687087..3687739 Replicon chromosome
Accession NZ_CP045913
Organism Serratia proteamaculans strain 336X

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag GHV41_RS17545 Protein ID WP_153859422.1
Coordinates 3687353..3687739 (+) Length 129 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag GHV41_RS17540 Protein ID WP_153859421.1
Coordinates 3687087..3687350 (+) Length 88 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GHV41_RS17525 3683459..3684376 - 918 WP_153859418.1 lipid kinase YegS -
GHV41_RS17530 3684865..3686217 - 1353 WP_153859419.1 tRNA 5-hydroxyuridine modification protein YegQ -
GHV41_RS17535 3686396..3686734 - 339 WP_153859420.1 YegP family protein -
GHV41_RS17540 3687087..3687350 + 264 WP_153859421.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
GHV41_RS17545 3687353..3687739 + 387 WP_153859422.1 type II toxin-antitoxin system VapC family toxin Toxin
GHV41_RS17550 3687736..3688452 - 717 WP_153860936.1 two-component system response regulator BaeR -
GHV41_RS17555 3688452..3689834 - 1383 WP_153859423.1 two-component system sensor histidine kinase BaeS -
GHV41_RS17560 3689831..3691261 - 1431 WP_153859424.1 MFS transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-119)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 129 a.a.        Molecular weight: 13976.16 Da        Isoelectric Point: 6.7001

>T142979 WP_153859422.1 NZ_CP045913:3687353-3687739 [Serratia proteamaculans]
MYMFDTNTVSQLFRRHPRLLGLMEKIPPSSVCISSITEAELLYGVAKRQSLTLKATVAAFLDSVTVYAWDSEAAHCYGTM
RAEMTKNGRVMGALDQLIAAHAQSCGATIVTNDKAFAMVPGLAVEDWT

Download         Length: 387 bp

>T142979 NZ_CP060919:c1041907-1041530 [Escherichia coli]
ATGAAAACATTACCTGACACACACGTACGGGAGGCATCGCGCTGCCCGTCTCCCGTCACCATCTGGCAGACACTGCTCAC
CCGACTGTTGGACCAGCATTACGGCCTCACACTGAATGACACACCGTTCGCTGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGCGATGCGGTGAACTTTCTCGTTGAAAAATACGCACTGGTACGTACCGACCAGCCAGGATTC
AGCGCCTGTACCCGTTCTCAGTTAATAAACAGTATTGATATCCTCCGGGCCCGCCGGGCAACCGGCCTGATGGCCCGCGA
CAATTACAGAACGGTAAATAACATTACCCTGGGTAAACATCCGGGGGCGAAACAATGA

Antitoxin


Download         Length: 88 a.a.        Molecular weight: 10172.50 Da        Isoelectric Point: 5.1351

>AT142979 WP_153859421.1 NZ_CP045913:3687087-3687350 [Serratia proteamaculans]
MERIAKLFKNGRNQAVRLPVEFEFDTDRVYIRRDREGNVILSKYPAKPDSWAPLLQMIAQTQVPQDFLTTEDRQQGMTTR
DPFAGEE

Download         Length: 264 bp

>AT142979 NZ_CP060919:c1042328-1041954 [Escherichia coli]
GTGTCAGACACTCTCCCCGGGACAACGCATCCCGACGATAACAACGACCGCCCCTGGTGGGGGCTACCCTGCACCGTGAC
GCCCTGTTTTGGGGCACGTCTGGTGCAGGAGGGTAACCGGTTGCATTACCTTGCAGACCGCGCCGGTATCAGAGGCCGGT
TCAGCGACGCGGATGCGTACCATCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGCCATCAGCATACCGTCACGCTGTATGCAAAAGGGCTGACCTGCAAAGCCGATACCCTCAGCAGTTG
TGGTTACGTTTATATGGCTGTTTATCCGACACTGGCACCCGCAACCACCTCATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References