Detailed information of TA system TA142976

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): cptAB/Cpta(toxin)
• Location: 3332547..3333216
• Replicon: chromosome
• Accession: NZ_CP045913
• Organism: Serratia proteamaculans strain 336X

Toxin (Protein)

• Gene name: cptA
• Uniprot ID: -
• Locus tag: GHV41_RS15895
• Protein ID: WP_153859212.1
• Coordinates: 3332794..3333216 (+)
• Length: 141 a.a.

Antitoxin (Protein)

• Gene name: cptB
• Uniprot ID: A0A2X2G343
• Locus tag: GHV41_RS15890
• Protein ID: WP_037418284.1
• Coordinates: 3332547..3332813 (+)
• Length: 89 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
GHV41_RS15865	3327648..3328301	+	654	WP_153859208.1	hypothetical protein	-
GHV41_RS15870	3328298..3329623	+	1326	WP_153859209.1	MHS family MFS transporter	-
GHV41_RS15875	3329674..3330282	-	609	WP_153859210.1	HD domain-containing protein	-
GHV41_RS15880	3330466..3331140	+	675	WP_012146602.1	hemolysin III family protein	-
GHV41_RS15885	3331231..3332223	-	993	WP_153859211.1	tRNA-modifying protein YgfZ	-
GHV41_RS15890	3332547..3332813	+	267	WP_037418284.1	FAD assembly factor SdhE	Antitoxin
GHV41_RS15895	3332794..3333216	+	423	WP_153859212.1	protein YgfX	Toxin
GHV41_RS15900	3333216..3333911	+	696	WP_012146598.1	two-component system response regulator CreB	-
GHV41_RS15905	3333908..3335326	+	1419	WP_153859213.1	two-component system sensor histidine kinase CreC	-
GHV41_RS15910	3335408..3336772	+	1365	WP_153859214.1	cell envelope integrity protein CreD	-
GHV41_RS15915	3336809..3337327	-	519	WP_153859215.1	flavodoxin FldB	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Inner membrane protein YgfX (2-131)

Antitoxin

• Flavinator of succinate dehydrogenase (7-79)

Sequences

Toxin

Protein

• Length: 141 a.a.
• Molecular weight: 16488.39 Da
• Isoelectric Point: 10.7372

>T142976 WP_153859212.1 NZ_CP045913:3332794-3333216 [Serratia proteamaculans]
VAQWRCDVRISWRTQLLSLLTHGALILLILISPWPEGYGPIWLVLLTLVVFECIRSQKRIASRQGELRLLENQRLGWHGQ
EWQLLKQPWMPRYGILLTLQPVGGKKRRRLWLASDSMAKADWRQLRQRLLYPPASDDEEP

Nucleotide

• Length: 423 bp

>T142976 NZ_CP060919:513156-513431 [Escherichia coli]
ATGAGAACCAAGGTACAGGCTTTACGGAAGAAACAAAAAAATACATTGGATCAAATAGTTAAAACTCCTGTTCCTCAAGG
GATCAAGTGGTCTGATATAGAGTCACTGGTTAAAGCATTAGGCGGAGAAATTAAGGAAGGAAGAGGTTCGCGTTGCAAGT
TCATACTAAATATGAGCGTTGCGTGTTTCCATCGGCCTCATCCGTCGCCAGATACCGATAAAGGCGCTGTAGAAAGCGTG
CGTGACTGGTTACTAAGTATAGGGGTAAAACCATGA

Antitoxin

Protein

• Length: 89 a.a.
• Molecular weight: 10472.93 Da
• Isoelectric Point: 4.7921

>AT142976 WP_037418284.1 NZ_CP045913:3332547-3332813 [Serratia proteamaculans]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDQLNDTDKALFIRLLESDDPDLFNWLMNHGAPQDSELQRMVTLIQTRN
KDRGPVAM

Nucleotide

• Length: 267 bp

>AT142976 NZ_CP060919:513428-513787 [Escherichia coli]
ATGATCAAACTGAAGACGCCAAACTCTATGGAGATTGCCGGGCAACCTGCAGTTATCACTTACGTGCCAGAACTGAATGC
ATTTCGTGGCAAATTCCTGGGCTTGTCAGGTTATTGTGATTTTGTCTCTGACAGCATTCAGGGGCTGCAAAAAGAAGGGG
AACTTTCCCTGCGAGAGTATCTTGAGGATTGTAAAGCTGCGGGTATTGAGCCGTATGCGCGTACAGAAAAGATTAAGACC
TTTACGTTACGCTATCCAGAATCGCTGAGTGAACGCCTTAATAATGCGGCTGCGCAGCAACAAGTCTCTGTTAATACCTA
TATTATTGAAACACTGAATGAGCGTTTGAATCATTTATAA

Structures

Antitoxin

• AlphaFold DB: A0A2X2G343