Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 1649844..1651467 Replicon chromosome
Accession NZ_CP045913
Organism Serratia proteamaculans strain 336X

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag GHV41_RS08090 Protein ID WP_153858210.1
Coordinates 1649844..1651166 (-) Length 441 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag GHV41_RS08095 Protein ID WP_112347975.1
Coordinates 1651171..1651467 (-) Length 99 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GHV41_RS08055 1645090..1645509 - 420 WP_153858204.1 hypothetical protein -
GHV41_RS08060 1645512..1646069 - 558 WP_153858205.1 type IV secretion protein Rhs -
GHV41_RS08065 1646150..1646554 - 405 WP_153858206.1 hypothetical protein -
GHV41_RS08070 1646790..1647041 + 252 WP_153858207.1 ash family protein -
GHV41_RS08075 1646962..1647270 + 309 WP_153858208.1 hypothetical protein -
GHV41_RS08080 1647525..1648643 + 1119 WP_153858209.1 HNH endonuclease -
GHV41_RS08085 1648776..1649747 + 972 WP_017891471.1 5'-nucleotidase -
GHV41_RS08090 1649844..1651166 - 1323 WP_153858210.1 type II toxin-antitoxin system HipA family toxin Toxin
GHV41_RS08095 1651171..1651467 - 297 WP_112347975.1 helix-turn-helix transcriptional regulator Antitoxin
GHV41_RS08100 1651675..1652310 - 636 WP_153858211.1 carbonic anhydrase -
GHV41_RS08105 1652566..1653642 - 1077 WP_153858212.1 Fic family protein -
GHV41_RS08110 1653960..1654079 + 120 Protein_1584 IS3 family transposase -
GHV41_RS08120 1654520..1655590 - 1071 WP_012005020.1 LPS export ABC transporter permease LptG -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 1639787..1651467 11680


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(8-108)

Antitoxin

Cro/C1-type helix-turn-helix domain

(21-68)


Sequences

Toxin        


Download         Length: 441 a.a.        Molecular weight: 49916.04 Da        Isoelectric Point: 6.8601

>T142971 WP_153858210.1 NZ_CP045913:c1651166-1649844 [Serratia proteamaculans]
MRRSQQRLAIWMNGIPVGYWEKHKGEDRLEYHPDWIADSQGRPLSLSLPFTPGNQLYRGNVVRDYFDNLLPDSEGIRRRL
AMRYHAESLDPFDLLAELGRDCVGAIQLLDIDEQPAHIFSIRQRPLSEAKIAEMLRNAATMLPGRQGQDDDLRLSIAGAQ
EKTALLWHDNQWCLPEGNTPTTHIFKLALGLVGNMRADMSTSIENEWLCSLILEHYGVPVARTAIAQFEDQKALIVERFD
RKLSSDKQWWIRLPQEDMCQALGFSPLKKYQSDGGPGITDIMEVLSRSDQAAADRRHFFKAQIIFWLLAATDGHAKNFSL
AHLPQNRYHMTPLYDVLSAWPVIGPGNSQIAWQKCKLAMAVRGSSNHYLISQIRRRHWIKHGEITGLGQQEVESIIEELL
ADTPGVIDRVADLLPGQFPSELAVKIFDGIKQQCARLAGR

Download         Length: 1323 bp

>T142971 NZ_CP060914:c4503411-4503034 [Escherichia coli]
ATGAAAACATTACCCGACACGCATGTACGGGAGGTATCGTGCTGCCCGTCTCCAGTCACCATCTGGCAGACACTGCTCAC
CCGACTGCTGGACCAGCACTACGGCCTTACGCTGAATGACACACCGTTCGCTGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGTGATGCAGTGAACTTTCTCGTGGAAAAATACGCACTGGTACGTACCGACCTGCCGGGATTC
AGCGCCTGTACCCACTCTCAGTTAATAAACAGCATCGATATCCTCCGGGCTCGCCGGGCAACAGGCCTGATGATCCGCGA
CAATTACAGAACGGTAAATAACATTACCCTGGGGAAGCATCCGGAGGCGAAACGATGA

Antitoxin


Download         Length: 99 a.a.        Molecular weight: 10988.55 Da        Isoelectric Point: 7.9765

>AT142971 WP_112347975.1 NZ_CP045913:c1651467-1651171 [Serratia proteamaculans]
MNTVYPLKTLSQLRPLLVGFRKAKGLTQKDVSERLGVTQQTYARLESNPASASLERLFRVFNVLGIEMVFSSELTSPGCE
TEEASAELINSPARREQW

Download         Length: 297 bp

>AT142971 NZ_CP060914:c4503869-4503501 [Escherichia coli]
GTGTCAGACACACTTTCCGGGACAACGCATCCCGATGACAATGACGACCATCCCTGGTGGGGACTACCCTGCACAGTGAC
GCCCTGTTTCGGCGCCCGTCTGGTGCAGGAGGGTAACCGGTTGCATTACCTTGCCGACCGTGCCGGTATCAGAGGCCGGT
TCAGAGATGCGGATGCGTACCCTCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGAAATTAATGCTCACCAGTGGT
GAACTGAATCCCCGCCATCAGCATACCGTGACACTGTATGCGAAGGGGCTGACCTGTGAAGCCGACACCCTCGGCTCCTG
TGGTTACGTTTATCTGGCTGTTTATCCGACACCTGAAACGAAAAAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References