Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 1649844..1651467 Replicon chromosome
Accession NZ_CP045913
Organism Serratia proteamaculans strain 336X

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag GHV41_RS08090 Protein ID WP_153858210.1
Coordinates 1649844..1651166 (-) Length 441 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag GHV41_RS08095 Protein ID WP_112347975.1
Coordinates 1651171..1651467 (-) Length 99 a.a.

Genomic Context

GHV41_RS08070GHV41_RS08075GHV41_RS08080GHV41_RS08085GHV41_RS08110GHV41_RS08055GHV41_RS08060GHV41_RS08065GHV41_RS08090GHV41_RS08095GHV41_RS08100GHV41_RS08105GHV41_RS08120
Location: 1646790..1647041 (252 bp)
Type: Others
Protein ID: WP_153858207.1
Location: 1646962..1647270 (309 bp)
Type: Others
Protein ID: WP_153858208.1
Location: 1647525..1648643 (1119 bp)
Type: Others
Protein ID: WP_153858209.1
Location: 1648776..1649747 (972 bp)
Type: Others
Protein ID: WP_017891471.1
Location: 1653960..1654079 (120 bp)
Type: Others
Protein ID: Protein_1584
Location: 1645090..1645509 (420 bp)
Type: Others
Protein ID: WP_153858204.1
Location: 1645512..1646069 (558 bp)
Type: Others
Protein ID: WP_153858205.1
Location: 1646150..1646554 (405 bp)
Type: Others
Protein ID: WP_153858206.1
Location: 1649844..1651166 (1323 bp)
Type: Toxin
Protein ID: WP_153858210.1
Location: 1651171..1651467 (297 bp)
Type: Antitoxin
Protein ID: WP_112347975.1
Location: 1651675..1652310 (636 bp)
Type: Others
Protein ID: WP_153858211.1
Location: 1652566..1653642 (1077 bp)
Type: Others
Protein ID: WP_153858212.1
Location: 1654520..1655590 (1071 bp)
Type: Others
Protein ID: WP_012005020.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
GHV41_RS080551645090..1645509-420WP_153858204.1hypothetical protein-
GHV41_RS080601645512..1646069-558WP_153858205.1type IV secretion protein Rhs-
GHV41_RS080651646150..1646554-405WP_153858206.1hypothetical protein-
GHV41_RS080701646790..1647041+252WP_153858207.1ash family protein-
GHV41_RS080751646962..1647270+309WP_153858208.1hypothetical protein-
GHV41_RS080801647525..1648643+1119WP_153858209.1HNH endonuclease-
GHV41_RS080851648776..1649747+972WP_017891471.15'-nucleotidase-
GHV41_RS080901649844..1651166-1323WP_153858210.1type II toxin-antitoxin system HipA family toxinToxin
GHV41_RS080951651171..1651467-297WP_112347975.1helix-turn-helix transcriptional regulatorAntitoxin
GHV41_RS081001651675..1652310-636WP_153858211.1carbonic anhydrase-
GHV41_RS081051652566..1653642-1077WP_153858212.1Fic family protein-
GHV41_RS081101653960..1654079+120Protein_1584IS3 family transposase-
GHV41_RS081201654520..1655590-1071WP_012005020.1LPS export ABC transporter permease LptG-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideGenomic island--1639787..165146711680


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(8-108)

Antitoxin

Cro/C1-type helix-turn-helix domain

(21-68)


Sequences

Toxin        


Download         Length: 441 a.a.        Molecular weight: 49916.04 Da        Isoelectric Point: 6.8601

>T142971 WP_153858210.1 NZ_CP045913:c1651166-1649844 [Serratia proteamaculans]
MRRSQQRLAIWMNGIPVGYWEKHKGEDRLEYHPDWIADSQGRPLSLSLPFTPGNQLYRGNVVRDYFDNLLPDSEGIRRRL
AMRYHAESLDPFDLLAELGRDCVGAIQLLDIDEQPAHIFSIRQRPLSEAKIAEMLRNAATMLPGRQGQDDDLRLSIAGAQ
EKTALLWHDNQWCLPEGNTPTTHIFKLALGLVGNMRADMSTSIENEWLCSLILEHYGVPVARTAIAQFEDQKALIVERFD
RKLSSDKQWWIRLPQEDMCQALGFSPLKKYQSDGGPGITDIMEVLSRSDQAAADRRHFFKAQIIFWLLAATDGHAKNFSL
AHLPQNRYHMTPLYDVLSAWPVIGPGNSQIAWQKCKLAMAVRGSSNHYLISQIRRRHWIKHGEITGLGQQEVESIIEELL
ADTPGVIDRVADLLPGQFPSELAVKIFDGIKQQCARLAGR

Download         Length: 1323 bp

>T142971 NZ_CP060914:c4503411-4503034 [Escherichia coli]
ATGAAAACATTACCCGACACGCATGTACGGGAGGTATCGTGCTGCCCGTCTCCAGTCACCATCTGGCAGACACTGCTCAC
CCGACTGCTGGACCAGCACTACGGCCTTACGCTGAATGACACACCGTTCGCTGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGTGATGCAGTGAACTTTCTCGTGGAAAAATACGCACTGGTACGTACCGACCTGCCGGGATTC
AGCGCCTGTACCCACTCTCAGTTAATAAACAGCATCGATATCCTCCGGGCTCGCCGGGCAACAGGCCTGATGATCCGCGA
CAATTACAGAACGGTAAATAACATTACCCTGGGGAAGCATCCGGAGGCGAAACGATGA

Antitoxin


Download         Length: 99 a.a.        Molecular weight: 10988.55 Da        Isoelectric Point: 7.9765

>AT142971 WP_112347975.1 NZ_CP045913:c1651467-1651171 [Serratia proteamaculans]
MNTVYPLKTLSQLRPLLVGFRKAKGLTQKDVSERLGVTQQTYARLESNPASASLERLFRVFNVLGIEMVFSSELTSPGCE
TEEASAELINSPARREQW

Download         Length: 297 bp

>AT142971 NZ_CP060914:c4503869-4503501 [Escherichia coli]
GTGTCAGACACACTTTCCGGGACAACGCATCCCGATGACAATGACGACCATCCCTGGTGGGGACTACCCTGCACAGTGAC
GCCCTGTTTCGGCGCCCGTCTGGTGCAGGAGGGTAACCGGTTGCATTACCTTGCCGACCGTGCCGGTATCAGAGGCCGGT
TCAGAGATGCGGATGCGTACCCTCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGAAATTAATGCTCACCAGTGGT
GAACTGAATCCCCGCCATCAGCATACCGTGACACTGTATGCGAAGGGGCTGACCTGTGAAGCCGACACCCTCGGCTCCTG
TGGTTACGTTTATCTGGCTGTTTATCCGACACCTGAAACGAAAAAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
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Antitoxin

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Source
ID
Structure
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References