Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | hipBA/HipA-HipB |
| Location | 1649844..1651467 | Replicon | chromosome |
| Accession | NZ_CP045913 | ||
| Organism | Serratia proteamaculans strain 336X | ||
Toxin (Protein)
| Gene name | hipA | Uniprot ID | - |
| Locus tag | GHV41_RS08090 | Protein ID | WP_153858210.1 |
| Coordinates | 1649844..1651166 (-) | Length | 441 a.a. |
Antitoxin (Protein)
| Gene name | hipB | Uniprot ID | - |
| Locus tag | GHV41_RS08095 | Protein ID | WP_112347975.1 |
| Coordinates | 1651171..1651467 (-) | Length | 99 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| GHV41_RS08055 | 1645090..1645509 | - | 420 | WP_153858204.1 | hypothetical protein | - |
| GHV41_RS08060 | 1645512..1646069 | - | 558 | WP_153858205.1 | type IV secretion protein Rhs | - |
| GHV41_RS08065 | 1646150..1646554 | - | 405 | WP_153858206.1 | hypothetical protein | - |
| GHV41_RS08070 | 1646790..1647041 | + | 252 | WP_153858207.1 | ash family protein | - |
| GHV41_RS08075 | 1646962..1647270 | + | 309 | WP_153858208.1 | hypothetical protein | - |
| GHV41_RS08080 | 1647525..1648643 | + | 1119 | WP_153858209.1 | HNH endonuclease | - |
| GHV41_RS08085 | 1648776..1649747 | + | 972 | WP_017891471.1 | 5'-nucleotidase | - |
| GHV41_RS08090 | 1649844..1651166 | - | 1323 | WP_153858210.1 | type II toxin-antitoxin system HipA family toxin | Toxin |
| GHV41_RS08095 | 1651171..1651467 | - | 297 | WP_112347975.1 | helix-turn-helix transcriptional regulator | Antitoxin |
| GHV41_RS08100 | 1651675..1652310 | - | 636 | WP_153858211.1 | carbonic anhydrase | - |
| GHV41_RS08105 | 1652566..1653642 | - | 1077 | WP_153858212.1 | Fic family protein | - |
| GHV41_RS08110 | 1653960..1654079 | + | 120 | Protein_1584 | IS3 family transposase | - |
| GHV41_RS08120 | 1654520..1655590 | - | 1071 | WP_012005020.1 | LPS export ABC transporter permease LptG | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Genomic island | - | - | 1639787..1651467 | 11680 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 441 a.a. Molecular weight: 49916.04 Da Isoelectric Point: 6.8601
>T142971 WP_153858210.1 NZ_CP045913:c1651166-1649844 [Serratia proteamaculans]
MRRSQQRLAIWMNGIPVGYWEKHKGEDRLEYHPDWIADSQGRPLSLSLPFTPGNQLYRGNVVRDYFDNLLPDSEGIRRRL
AMRYHAESLDPFDLLAELGRDCVGAIQLLDIDEQPAHIFSIRQRPLSEAKIAEMLRNAATMLPGRQGQDDDLRLSIAGAQ
EKTALLWHDNQWCLPEGNTPTTHIFKLALGLVGNMRADMSTSIENEWLCSLILEHYGVPVARTAIAQFEDQKALIVERFD
RKLSSDKQWWIRLPQEDMCQALGFSPLKKYQSDGGPGITDIMEVLSRSDQAAADRRHFFKAQIIFWLLAATDGHAKNFSL
AHLPQNRYHMTPLYDVLSAWPVIGPGNSQIAWQKCKLAMAVRGSSNHYLISQIRRRHWIKHGEITGLGQQEVESIIEELL
ADTPGVIDRVADLLPGQFPSELAVKIFDGIKQQCARLAGR
MRRSQQRLAIWMNGIPVGYWEKHKGEDRLEYHPDWIADSQGRPLSLSLPFTPGNQLYRGNVVRDYFDNLLPDSEGIRRRL
AMRYHAESLDPFDLLAELGRDCVGAIQLLDIDEQPAHIFSIRQRPLSEAKIAEMLRNAATMLPGRQGQDDDLRLSIAGAQ
EKTALLWHDNQWCLPEGNTPTTHIFKLALGLVGNMRADMSTSIENEWLCSLILEHYGVPVARTAIAQFEDQKALIVERFD
RKLSSDKQWWIRLPQEDMCQALGFSPLKKYQSDGGPGITDIMEVLSRSDQAAADRRHFFKAQIIFWLLAATDGHAKNFSL
AHLPQNRYHMTPLYDVLSAWPVIGPGNSQIAWQKCKLAMAVRGSSNHYLISQIRRRHWIKHGEITGLGQQEVESIIEELL
ADTPGVIDRVADLLPGQFPSELAVKIFDGIKQQCARLAGR
Download Length: 1323 bp
>T142971 NZ_CP060914:c4503411-4503034 [Escherichia coli]
ATGAAAACATTACCCGACACGCATGTACGGGAGGTATCGTGCTGCCCGTCTCCAGTCACCATCTGGCAGACACTGCTCAC
CCGACTGCTGGACCAGCACTACGGCCTTACGCTGAATGACACACCGTTCGCTGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGTGATGCAGTGAACTTTCTCGTGGAAAAATACGCACTGGTACGTACCGACCTGCCGGGATTC
AGCGCCTGTACCCACTCTCAGTTAATAAACAGCATCGATATCCTCCGGGCTCGCCGGGCAACAGGCCTGATGATCCGCGA
CAATTACAGAACGGTAAATAACATTACCCTGGGGAAGCATCCGGAGGCGAAACGATGA
ATGAAAACATTACCCGACACGCATGTACGGGAGGTATCGTGCTGCCCGTCTCCAGTCACCATCTGGCAGACACTGCTCAC
CCGACTGCTGGACCAGCACTACGGCCTTACGCTGAATGACACACCGTTCGCTGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGTGATGCAGTGAACTTTCTCGTGGAAAAATACGCACTGGTACGTACCGACCTGCCGGGATTC
AGCGCCTGTACCCACTCTCAGTTAATAAACAGCATCGATATCCTCCGGGCTCGCCGGGCAACAGGCCTGATGATCCGCGA
CAATTACAGAACGGTAAATAACATTACCCTGGGGAAGCATCCGGAGGCGAAACGATGA
Antitoxin
Download Length: 99 a.a. Molecular weight: 10988.55 Da Isoelectric Point: 7.9765
>AT142971 WP_112347975.1 NZ_CP045913:c1651467-1651171 [Serratia proteamaculans]
MNTVYPLKTLSQLRPLLVGFRKAKGLTQKDVSERLGVTQQTYARLESNPASASLERLFRVFNVLGIEMVFSSELTSPGCE
TEEASAELINSPARREQW
MNTVYPLKTLSQLRPLLVGFRKAKGLTQKDVSERLGVTQQTYARLESNPASASLERLFRVFNVLGIEMVFSSELTSPGCE
TEEASAELINSPARREQW
Download Length: 297 bp
>AT142971 NZ_CP060914:c4503869-4503501 [Escherichia coli]
GTGTCAGACACACTTTCCGGGACAACGCATCCCGATGACAATGACGACCATCCCTGGTGGGGACTACCCTGCACAGTGAC
GCCCTGTTTCGGCGCCCGTCTGGTGCAGGAGGGTAACCGGTTGCATTACCTTGCCGACCGTGCCGGTATCAGAGGCCGGT
TCAGAGATGCGGATGCGTACCCTCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGAAATTAATGCTCACCAGTGGT
GAACTGAATCCCCGCCATCAGCATACCGTGACACTGTATGCGAAGGGGCTGACCTGTGAAGCCGACACCCTCGGCTCCTG
TGGTTACGTTTATCTGGCTGTTTATCCGACACCTGAAACGAAAAAGTAA
GTGTCAGACACACTTTCCGGGACAACGCATCCCGATGACAATGACGACCATCCCTGGTGGGGACTACCCTGCACAGTGAC
GCCCTGTTTCGGCGCCCGTCTGGTGCAGGAGGGTAACCGGTTGCATTACCTTGCCGACCGTGCCGGTATCAGAGGCCGGT
TCAGAGATGCGGATGCGTACCCTCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGAAATTAATGCTCACCAGTGGT
GAACTGAATCCCCGCCATCAGCATACCGTGACACTGTATGCGAAGGGGCTGACCTGTGAAGCCGACACCCTCGGCTCCTG
TGGTTACGTTTATCTGGCTGTTTATCCGACACCTGAAACGAAAAAGTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|
Antitoxin
| Source | ID | Structure |
|---|